A simplified isolation procedure of four cocarcinogenic phorbolesters from croton oil

Zusammenfassung Die schonende Reindarstellung von 4 kokarzinogenen Phorbolestern aus Krotonöl gelingt bereits nach 3 konsekutiven Trennoperationen (O'Keeffe-Gegenstromverteilung, Adsorptionschromatographie, Craig-Verteilung), deren Ausführung präzis beschrieben wird.     

Fifty years of amanitin

Pharmacokinetic studies have provided new insights into humanAmanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, α-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis.     

Fifty years of amanitin.

Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, alpha-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis.     

Survival of bull spermatozoa after exposure to 150 atm N2 for 15 days

Zusammenfassung Bullenspermien überleben in N₂ bei 150 atm und + 6°C gut 8 Tage (bis 14 Tage). In H₂ bei 100 atm und + 6°C nimmt die Überlebensfähigkeit ab. An den Spermien wurden Schäden durch Entwicklung von Gasbläschen bei Drucksenkung beobachtet. Weitere Versuche bei höherem Druck sind in reiner Flüssigkeitsumgebung auszuführen.