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选健康猕猴20只分成三组:Ⅰ正常组,Ⅱ高脂血症组、Ⅲ橡胶种子油+高脂血症组。造型五个月后分别测定血清和红细胞内的血脂。试验结果提示:橡胶种子油除可抑制高胆固醇及高脂饮食所诱发的血脂升高的程度外,可以减少血清内脂质向红细胞的侵入或促进红细胞内的胆固醇外移,这可能是橡胶种子油抗动脉粥样硬化的原理之一.  相似文献   

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J Smith  M Fauquet  C Ziller  N M Le Douarin 《Nature》1979,282(5741):853-855
Specific to the vertebrate embryo, the neural crest is a transitory structure whose constituent cells migrate extensively through the developing animal and ultimately give rise to many distinct cell types, including the components of the peripheral nervous system. The earliest clear indices of their differentiation have so far been detected only when cells from the crest have reached their destination. This is exemplified by the acquisition of the ability to synthesise and store catecholamines; absent from crest cells before and during their dorso-ventral migration, this ability appears concomitantly with their aggregation into the primary sympathetic ganglia. The chronology of cholinergic maturation, however, is less well defined. Appropriate biochemical markers are demonstrable as soon as parasympathetic or enteric ganglia are formed, but the lack of a suitable cytochemical method is a major obstacle to the identification of any cholinergic cells before then. Although acetylcholinesterase (AChE) is present in migrating neural crest, choline acetyltransferase (CAT), the enzyme catalysing acetylcholine (ACh) synthesis, is a much more relevant correlate, and definitive evidence for cholinergic differentiation should include the demonstration of ACh-synthesising activity in intact cells or their extracts. We show here that neural crest, as soon as it begins migration, can synthesise ACh.  相似文献   

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Membrane-bound phosphoinositides are signalling molecules that have a key role in vesicle trafficking in eukaryotic cells. Proteins that bind specific phosphoinositides mediate interactions between membrane-bounded compartments whose identity is partially encoded by cytoplasmic phospholipid tags. Little is known about the localization and regulation of mammalian phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2), a phospholipid present in small quantities that regulates membrane trafficking in the endosome-lysosome axis in yeast. Here we describe a multi-organ disorder with neuronal degeneration in the central nervous system, peripheral neuronopathy and diluted pigmentation in the 'pale tremor' mouse. Positional cloning identified insertion of ETn2beta (early transposon 2beta) into intron 18 of Fig4 (A530089I17Rik), the homologue of a yeast SAC (suppressor of actin) domain PtdIns(3,5)P2 5-phosphatase located in the vacuolar membrane. The abnormal concentration of PtdIns(3,5)P2 in cultured fibroblasts from pale tremor mice demonstrates the conserved biochemical function of mammalian Fig4. The cytoplasm of fibroblasts from pale tremor mice is filled with large vacuoles that are immunoreactive for LAMP-2 (lysosomal-associated membrane protein 2), consistent with dysfunction of the late endosome-lysosome axis. Neonatal neurodegeneration in sensory and autonomic ganglia is followed by loss of neurons from layers four and five of the cortex, deep cerebellar nuclei and other localized brain regions. The sciatic nerve exhibits reduced numbers of large-diameter myelinated axons, slowed nerve conduction velocity and reduced amplitude of compound muscle action potentials. We identified pathogenic mutations of human FIG4 (KIAA0274) on chromosome 6q21 in four unrelated patients with hereditary motor and sensory neuropathy. This novel form of autosomal recessive Charcot-Marie-Tooth disorder is designated CMT4J.  相似文献   

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从液压阻尼器动力学模型入手,考虑油液含气量对油液压缩性的影响,建立了带定压活门的液压阻尼器动力学模型.对阻尼器在不同激振下的阻尼力及等效阻尼进行了数值仿真,仿真结果表明理论结果与实验值符合,验证了该模型的准确性.对不同含气量时阻尼器的响应进行计算,证实了油气混合会降低液压阻尼器的阻尼力和等效阻尼.将理论模型用于预估双频激振下的阻尼器等效阻尼,发现高频背景振动使低频小幅值扰动的等效阻尼严重下降,而对低频大幅值扰动等效阻尼的影响则要小得多.  相似文献   

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北朝时期,佛教在北方广为流播。在佛教经典所倡导的福田思想的影响下,广大信众积极投身于社会救济事业。他们通过救助贫乏、赈济饥荒、举办斋会、施医舍药、敛葬贫民等方式,对大乘佛教所倡导的菩萨行思想予以践行。从根本上说,根植于佛教信仰基础上的社会救济是佛教教团传播宗教信仰并促使信众皈依的一种方式,但是,它对于弥补政府在社会保障方面的缺失,打破依靠血缘和地缘维系的联合,缓和社会矛盾,稳定统治秩序都起到了至关重要的作用。  相似文献   

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针对如何使图像中的浮雕效果更具有立体感的问题,设计了关于图像的5阶细胞神经网络(CNN)的浮雕算法研究的方案,研究了该算法对于图像的立体化处理的过程,对于同一图像分别采用5阶CNN、3阶CNN算法和拉普拉斯算法进行对图像的立体化处理,并比较了几类算法的优劣.实验表明,基于5阶CNN浮雕算法更接近现实,直观效果更好,在实现图像的实时处理中,能够有效地生成具有艺术效果的浮雕图像.同时,将其应用在遥感图像的处理工作中,取得了很好的效果.  相似文献   

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《人民日报》从2008年5月16日开始推出“抗震救灾特刊”,对2008年5月12日在四川省汶川县发生的8.0级特大地震这一重大自然灾难进行集中报道。试从报道内容、报道策略、新闻图片的角度对”抗震救灾特刊”进行分析,并对该特刊的报道特点作出总结。  相似文献   

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Vision in monkeys after removal of the striate cortex   总被引:5,自引:0,他引:5  
N K Humphrey  L Weiskrantz 《Nature》1967,215(5101):595-597
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实验猴弯曲菌感染情况调查研究   总被引:3,自引:0,他引:3  
调查了1 722只健康实验猴,检出弯曲菌阳性率为56.91%,调查结果显示,食蟹猴和恒河猴弯曲菌阳性率没有显著差异;实验猴弯曲菌的感染与年龄有关,未成年猴弯曲菌阳性率极显著地高于成年猴;实验猴弯曲菌阳性率在干燥饲养环境极显著地低于潮湿环境.同时对部分菌株,用K-B法进行了药敏试验,用APICampy System进行了分类鉴定.  相似文献   

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目的:观察甘利欣治疗抗结核药药物性肝炎的临床疗效.方法:将48例抗结核药引起的药物性肝炎患者随机分成治疗组27例和对照组21例.治疗组给予甘利欣治疗4周,对照组给予能量合剂治疗4周,观察治疗前后临床症状和血生化指标的变化.结果:治疗组患者的临床症状和肝功能改善情况显著优于对照组(P〈0.05).结论:甘利欣有很好的保肝、降酶作用,未见不良反应.  相似文献   

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仰鼻猴属及其下几个种的分类地位长期以来处于争论和变化当中,这与整个疣猴亚科分类体系的变动有密切关系。近年来,仰鼻猴研究有较大进展。在分类学上,重新确认了仰鼻猴属(Rhinopithecus)的地位,最初发表的四个种[川仰鼻猴(roxellana)、滇仰鼻猴(R.bieti)、黔仰鼻猴(R.brelichi)和越南仰鼻猴(R.avunculus)]均为有效种;在川仰鼻猴中,区别出三个亚种,即指名亚种R.r.roxellana,秦岭亚种R.R.qinlingensis和湖北亚种R.r.hubeiensis。  相似文献   

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目的 通过正常人群了解Stroop测验的结果是否存在性别、年龄和学历上存在差异;通过单纯额叶、颞叶和顶叶卒中的病人了解是Stroop测验可能的神经功能区域.方法 研究采用中文版Stroop测验和简易智能量表,数据处理采用SPSS13.0软件据包进行分析和处理.结果 正常人Stroop测验结果与性别无关(P〉0.05),与年龄有关(P 〈0.05),与教育程度有关(P 〈0.05).卒中的病人按照左右半球损害分组无差异(P 〉0.05),按照损害额叶、颞叶和顶叶分组无差异(P 〈0.05).结论 正常人群Stroop测验结果与年龄和学历有关,无性别的差异.Stroop测验结果没有左右半球的差异,但是存在功能分区的差异,在额叶、颞叶和顶叶中,额叶的影响可能更大.  相似文献   

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针对液压元件溢流阀发生故障时,其振动信号具有非线性的特点,以关联维数描述信号特性,采用G-P算法分别对溢流阀阀体正常和故障时的振动信号进行计算分析.溢流阀工作正常时阀体振动信号的关联维数值较大,发生故障时关联维数值较小,且不同状态下关联维不同.研究表明,采用关联维数诊断系统故障的方法是可行有效的.  相似文献   

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