On the role of antidiuretic hormone in volume natriuresis and polyuria in rats

Zusammenfassung An Ratten wird gezeigt, dass eine ADH-Infusion in niedriger Dosierung die Natriurese unter einer Belastung mit physiologischer NaCl nicht beeinflusst, während das Urinvolumen reduziert wird.

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Acknowledgement. Skilful technical assistance of Mrs.M. Blaková is sincerely appreciated.     

The composition of the renal medulla during natriuresis accompanying saline loading in the rat

Zusammenfassung In 38 Ratten wurde die Na- und Harnstoff-Konzentration im Gewebewasser der Nierenrinde, des Nierenmarks und der Papillenspitze nach einer Infusion von isotoner Kochsalzlösung festgestellt. Die Konzentration beider Stoffe war in der Papillenspitze und in dem Nierenmark bedeutend niedriger als bei den Kontrollratten.     

Neurohypophyseal origin of a humoral factor restoring volume natriuresis in acutely hypophysectomized rats

Zusammenfassung Es wird gezeigt, dass die Natriumund Wasserausscheidung hypophysektomierter Ratten durch ein Hypophysenhinterlappenextrakt korrigiert werden kann. Es handelt sich dabei nicht um ADH und das natriuretische Prinzip scheint auch vom Oxytozin verschieden zu sein.

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The present results and conclusions were discussed in detail by one of the authors (B. L.) in his Purkynje Lecture on Interaction of hormonal and non-hormonal mechanisms of the body fluids volume regulation at the XIXth Meeting of the Czechoslovak Physiological Society, held in Prague on January 26–28, 1972.

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Acknowledgments. We wish to thank Mrs.E. Blaková for her skilled technical assistance.     

The role of volume expansion,of prostaglandins and catecholamines in the development of acute renal failure

Summary A single injection either of isotonic or hypertonic saline solutions protected rats against acute renal failure (ARF) induced with glycerol. This protection was accompanied by increased urinary prostaglandin E (PGE) concentration. On the contrary, a single s.c. injection either of hypotonic saline or isotonic glucose solution, which did not increase urinary PGE concentration, or depletion of the endogenous catecholamines, using reserpine, did not protect the animals against acute renal failure.The authors wish to thank Miss Sylvie Bompis and Miss Ermione-Loukia Ghikas for their technical assistance and Mr Richard Irvine B.A. for his help with the English.     

On the role of divalent cations in the reaction mechanism of malic enzyme.

The kinetic order of addition of Mg2+ and L-malate to malic enzyme has been determined. Mg2+ is the first to bind, and probably acts as a link between the substrate and the active site.     

On the mechanism of immunosympathectomy

Summary The effects in vivo and in vitro of the antiserum to mouse nerve growth factor (NGF) are independent of the presence of complement. These results are consistent with the view that the antiserum acts by neutralizing endogenous NGF.Acknowledgments. Financial support from the Whitehall Foundation, New York, The Wellcome Foundation, U.K. (to J.R.C.) and the Science Research Council (Studentship to M.E.) is gratefully acknowledged. We thank Professor J.H. Humphrey, National Institute for Medical, Research, Mill Hill, London, for discussion and determination of plasma C3 levels.     

Amniotic fluid volume in experimentally induced renal agenesis and anencephaly

Zusammenfassung Experimentelle Prüfung beim Goldhamster,Mesocricetus auratus, ob Nieren- oder Gehirnmissbildungen einen Einfluss auf die Quantität der Amnionflüssigkeit ausüben, was nur für die Gehirnmissbildungen bejaht werden konnte.

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This work was supported by research grants from the Easter Seal Research Foundation of the National Society for Crippled Children and Adults, Inc. and from USPHS grant No. HD 03298.     

A possible role of microtubules in the C cells secretory mechanism

Riassunto Le modalità di secrezione dei granuli contenenti Calcitonina da parte delle cellule C sono state studiate in tiroidi di cane in condizioni normali e in coltura organotipica con alto tenore di calcio. È stata notata la presenza di numerosi microtubuli alla periferia delle cellule e alcune immagini suggeriscono un attacco dei microtubuli ai granuli secretori. Viene prospettato che i microtubuli abbiano importanza nel meccanismo di secrezione delle cellule C e forse delle cellule della serie APUD in generale, e che questo possa essere del tipo «emiocitosi».     

Acute effect of hypophysectomy on the natriuresis following saline infusion in dogs.

The natriuresis following an i.v. isotonic saline loading corresponding to 10% of body wt. was markedly decreased after acute hypophysectomy, due to lowered urinary sodium concentration, in anaesthetized dogs. A role of the pituitary in such a homeostatic natriuresis is suggested.     

On the mechanism of compensatory hypertrophy in skeletal muscles

Riassunto L'ipertrofia compensatoria dei muscoli soleo e plantare di ratto in seguito a tenotomia del sinergista gastrocnemio non appare mediata dall'innervazione, ma è verosimilmente legata a un effetto diretto della accresciuta tensione meccanica sui muscoli interessati.