Increased vascular permeability induced in synovialis of the rat by histamine,serotonin and bradykinin

Résumé La perméabilité vasculaire de la membrane synoviale du rat est augmentée par l'histamine, la sérotonine et la bradykinine. Dans cette réaction la sérotonine est plus active que l'histamine et la bradykinine.

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L.P.B. is supported by a Medical Postgraduate Research Scholarship from the National Health and Medical Research Council of Australia.

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We are indebted to Associate ProfessorJ. Garcia-Lémé, University of São Paulo, Brazil, for advice.     

Time courses and refractoriness of enhanced vascular permeability induced by histamine,serotonin and bradykinin in synovialis of the rat

Summary Enhanced vascular permeability induced in synovialis of the rat by histamine and serotonin lasts 5–15 min and that induced by bradykinin less than 5 min. Synovialis of the rat becomes refractory to the permeability effects of repeated doses of each of these substances in the hour following initial application.This work was carried out while L.P.B. was supported by a Medical Postgraduate Scholarship from the National Health and Medical Research Council of Australia.     

The effect of bradykinin on permeability of skin blood vessels

Zusammenfassung Es werden quantitative Vergleiche in 3 Spezies der Hautgefäss-Empfindlichkeit gegenüber Bradykinin und Histamin angestellt.     

The influence of intraperitoneal adaptation to histamine on the histamine ulcerations in the guinea-pig

Résumé Les cobyes adaptés à l'histamine par voie intrapéritonéale sont protegés contre l'ulcère de l'estomac posthistaminique.

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The work was supported by grants from the Polish Academy of Sciences.     

Platelets, endothelium and blood vessel wall

Aggregating platelets cause contraction of vascular smooth muscle, because they release serotonin and thromboxane A2. If the platelets aggregate in a blood vessel with intact intima, the platelet-products cause endothelium-dependent relaxation of the underlying smooth muscle. Hence, the presence of an intact intima considerably reduces the vasospastic response to platelet-aggregation. The major platelet products which trigger endothelium-dependent relaxations are the adenine nucleotides and serotonin. The ability of the endothelium to prevent platelet-induced vasospasm is augmented after chronic intake of cod liver oil, but is reduced after previous intimal injury.     

The effect of bradykinin on blood flow and heat production in the myocardium

Résumé En utilisant comme méthode la calorimétrie interne, nous avons montré que la bradykinine synthétique abaisse la résistance vasculaire dans le myocarde du lapin, du chat et du singe, même à doses aussi réduites que 0,05 µg/kg. Des doses plus fortes (5 µg/kg) augmentent aussi l'activité métabolique du myocarde.     

Effect of lithium chloride on the rat's paw edema induced by serotonin,histamine and formalin

Résumé Administration parentérale de chlorure de lithium inhibe l'dème de la patte produit par l'injection locale de serotonine, histamine ou formol chez le rat normal mais non pas chez le rat surrénaléctomizé. Ces resultats suggerent que l'effect antiphlogistique du chlorure de lithium est du à une liberation de corticosteroïdes.

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I should like to thank Sandoz, Basel (Switzerland) for supplying serotonin (5-Hydroxytryptamine creatine sulfate) and Merck, AG Darmstadt, for histamine hydrochloride. The technical assistance of Mr.B. Koç and Mr.V. Balolu is greatly appreciated.     

The influence of chlorothiazide and tolbutamide upon intestinal serotonin levels in the sprague-dawley rat

Zusammenfassung Der Serotoningehalt der Schleimhaut im obern Duodenumteil, im mittleren Jejunum, im Ileumendteil und im Appendix von Sprague-Dawley Charles River Rattenmännchen wurde ohne Vorbehandlung und mit Chlorothiazid- und Tolbutamidvorbehandlung spektrophotofluorimetrisch bestimmt. Die Serotoningehalte für die 3 Gruppen vergleichbarer Gewebe waren ähnlich, was zeigt, dass die früher beschriebene Erhöhung des Serotoningehaltes der Schleimhaut nach Sulfamerazinvorbehandlung wahrscheinlich nicht mit einer unspezifischen Wirkung des Sulfonamidteils verbunden ist.

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This study was supported in part by an award from the National Science Foundation toJ. H. Thompson, M.D., M.R.C.P.I., Department of Pharmacology, U.C.L.A. School of Medicine, Los Angeles, California 90024.     

Responses of isolated blood vessels to acetylcholine,epinephrine, norepinephrine,and histamine

Zusammenfassung Acetylcholin verursachte in den Coronar-, Femoral- und Mesenterialarterien, Catecholamine in den Femoral- und Mesenterialgefässen Konstriktionen, in den Coronargefässen hingegen Dilatation.

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This work was completed in the Department of Physiology, University of Mississippi Medical Center, Jackson (Mississippi USA).