共查询到20条相似文献,搜索用时 31 毫秒
1.
L. Hiripi K. S. Rózsa T. A. Miller 《Cellular and molecular life sciences : CMLS》1979,35(10):1287-1288
Summary Proctolin at concentrations 10–8–10–7 M elevated by 40% brain adenylate cyclase activity of adultLocusta migratoria migratorioides R.F. In moulting individuals, proctolin caused a decrease in brain adenylate cyclase activity, and it proved to be ineffective in the larvae. Proctolin caused only a slight decrease on guanylate cyclase activity of the brain at every developmental stage. 相似文献
2.
Zusammenfassung Strychnin in einer Konzentration von 3×10–6 bis 3,5×10–5
M/l verursacht eine vorübergehende Vergrösserung derb-Welle des ERG der isolierten Kaninchennetzhaut, in einer Konzentration von 7×10–5 bis 7×10–4
M/l verkleinert es dieb-Welle. Aus den Ergebnissen wird geschlossen, dass die Substanz zumindest teilweise schon auf die Schicht des zweiten Neurons wirkt. 相似文献
3.
Summary ATPases of the amine storing granules from bovine adrenal medulla and splenic nerves are inhibited by Tl+++ 3×10–5 and 5×10–6
M, respectively. Tl+ up to 10–3
M is ineffective. By T1+++ in concentrations of 10–4
M or more, proteins are precipitated, so that the enzyme inhibiton by these concentrations is unspecific. If T1+ is oxidized to Tl+++ in the organism, the inhibition of granular ATPase may be responsible for the alterations of the catecholamine metabolism observed in thallium intoxication. 相似文献
4.
Lisbeth Fries 《Cellular and molecular life sciences : CMLS》1973,29(11):1436-1437
Zusammenfassung Wachstumstimulation von 2,3-Dibromo-4,5-Dihydroxybenzylalkohol (Lanosol) in Konzentrationen von 4×10–5–4×10–6 wurde in axenischen Kulturen der RotalgenGoniotrichum alsidii undPolysiphonia urceolata festgestellt. Während das Disulfatdikaliumsalz nicht toxisch und von niedrigerer Aktivität war, hatte 2×10–4
M Lanosol eine Hemmwirkung aufPolysiphonia. 相似文献
5.
Summary With a suitable modification of the Farquhar and Palade technique the Na++K+-ATPase activity in guineapig thyroid is demonstrated. The addition of c-AMP (5×10–6 M or 1.5×10–5 M) to the incubation media produced an apparent intensification of the Na++K+-ATPase activity in the thyroid.This work was supported by a grant from ZMNU of Serbia. 相似文献
6.
Nuclei were isolated from protoplasts of a haploid auxotrophicAspergillus nidulans strain. Transformation of protoplasts prepared from a complementary haploid auxotrophic strain with these purified nuclei resulted in both heterokaryotic and diploid colonies. The nutritionally-complementing colonies appeared at a frequency of 5×10–7 to 10–8. 相似文献
7.
A. Vaishampayan 《Cellular and molecular life sciences : CMLS》1985,41(1):137-139
Summary Diuron (DCMU) is inhibitory to the photoautotrophic and photoheterotrophic growth of the N2-fixing blue-green algaNostoc muscorum at concentrations of 1.0×10–5 M and 2.0×10–5 M, respectively. A mutant of this organism resistant to 5.0×10–5 M DCMU under its photoheterotrophic growth conditions, with the ability to utilize DCMU as a carbon and nitrogen source for growth, and complete inability to grow photoautotrophically has been isolated. With the apparent defect in its photosynthetic ability, it is suggested that theDCMU
r mutant lacks the step inhibited by 1.0×10–5 M DCMU, and metabolizes DCMU by an existing enzyme system in the absence of such inhibition. That this enzyme may be glutamine synthetase (GS) is explained with the help of a L-methionine-DL-sulfoximine (MSO)-resistant mutant ofN. muscorum which is able to grow faster with 2.0×10–5 DCMU and is known to contain an altered GS.Thanks are due to the Council of Scientific and Industrial Research, CSIR Complex, Govt. of India, New Delhi-110012, for appointing the author to the Scientists' Pool for undertaking researches on the physiological and genetic controls of nitrogen metabolism in blue-green algae, a part of which is presented in this literature. 相似文献
8.
Summary The absorption of3H-digitoxin from perfused rat small intestine was inhibited by probenecid (1.0×10–2
M), ethacrynic acid (0.5×10–3
M), and mersalyl (8.0×10–3
M) indicating that digitoxin absorption is at least partly an active process. 相似文献
9.
Amaya Aleixandre P. Garcia de Jalón Isabel Martin 《Cellular and molecular life sciences : CMLS》1981,37(12):1318-1320
Summary The antibiotic bacitracin (5×10–5–4×10–4 M) increases the inhibition of the contractile response caused by both enkephalin release and direct application of Met-enkephalin 5×10–7 M in the longitudinal muscle strip preparation from guinea-pig ileum. This effect is attributed to an inhibition of enkephalin degrading peptidases by bacitracin. 相似文献
10.
Zusammenfassung Bei Prüfung des Einflusses vonp-Benzochinon auf die Aktivität der partiell gereinigten IES-Oxidase aus Wurzeln von Maiskeimlingen wurde bei Konzentrationen von 5×10–6 bis 5×10–4
M eine 50-bzw. 100%ige Hemmung beobachtet. 相似文献
11.
S. S. Sharma 《Cellular and molecular life sciences : CMLS》1985,41(1):45-46
Summary Mercuric acetate, at 5.0×10–5 M, stimulates the mobilization of total nitrogen and phosphate reserves from cotyledons during seedling growth inCicer arietinum cv H208 whereas it suppresses the same process at 2.5×10–4 M.Thanks are due to Dr D. Banerji for providing facilities and helpful suggestions. 相似文献
12.
Summary The hydrolysis of acetylcholine chloride (0.01M) by frog's rectus extracts, is inhibited by low concentrations of 3318 CT (CI-50 3.2×10–7) and high concentrations of D.F.P. (CI-50 1.3×10–5). Inversely, the hydrolysis of butyrylcholine perchlorate is inhibited by low concentrations of D.F.P. (CI-50 3×10–9) and high concentrations of 3318 CT (CI-50 3×10–4). Both are inhibited by similar concentrations of neostigmine (CI-50 1.1×10–7 and 1.5×10–7). Frog's rectus thus contains true and pseudo-cholinesterases. The inhibitions produced by D.F.P. added to the muscle itself (and not the extract) correlates well with the potentiation of the corresponding ester. Sensitization to AcCh and to BuCh appears to be specifically related to the inhibition of Ac ChE for the former ester, of XChE for the second one. 相似文献
13.
R. G. G. Andersson H. J. Arnqvist L. Lundholm 《Cellular and molecular life sciences : CMLS》1976,32(5):601-602
Summary The incorporation of leucice-14C into protein in bovine mesenteric arteries was augmented by cyclic GMP (10–3
M) and decreased by cyclic AMP (10–3
M). There was no effect of 5 AMP (10–3
M). The phosphodiesterase inhibiting drugs theophylline (10–3
M) and papaverine (5×10–5 g/ml) both decreased the leucine-14C incorporation.We are indebted to Mrs.Lena Burlin for hear assistance. Finacial support has been provided by the Swedish State Medical Research Council (No. 04X-101X-4498). 相似文献
14.
A. Velasco-Martin P. Lorenzo-Fernandez P. D. Garcia de Jalon 《Cellular and molecular life sciences : CMLS》1973,29(9):1100-1101
Resumen El Sulpiride in vitro a la concentración de 1×10–2
M disminuye el consumo de Oxígeno en cortes de cerebro de rata. El exceso de potasio o ausencia de calcio en el medio de incubación, no modifican este efecto. En homogeneizado de cerebro total, unicamente a la concentración de 1×10–2
M deprime el consumo de oxígeno. A las concentraciones 1×10–3 y 1×10–4
M no modifica el consumo de oxígeno en cortes ni homogeneizados de cerebro. 相似文献
15.
A. Velasco Martín J. M. Arévalo Alonso J. Castaneda Casado 《Cellular and molecular life sciences : CMLS》1972,28(9):1070-1071
Resumen El clorhidrato de Ketamina (1×10–3
M y 1×10–4
M) incrementa el consumo de oxigeno de cortes de cerebro de rata incubados en Krebs-Ringer fosfato conteniendo 5 mM ó 100 mM de potasio. La droga no modifica el consumo de oxigeno de homogeneizado de cerebro total. 相似文献
16.
B. Giordana F. Giordana F. Repetto A. Bianchi 《Cellular and molecular life sciences : CMLS》1973,29(10):1243-1244
Riassunto É stato studiato l'effetto della ouabaina sul trasporto di Na, Cl e fluido in digiuno e ileo isolato di coniglio. Mentre in entrambi i tratti intestinali il flusso mucosa-serosa di Na è inibito dal glicoside, il flusso nello stesso senso di Cl, di cui è stata dimostrata una componente attiva, non viene modificato. Poichè inoltre il trasporto di fluido viene inibito dalla ouabaina in misura diversa in digiuno e in ileo, si suggerisce la presenza di sistemi ATPasici non ouabaino-sensibili accanto alla Na–K ATPasi sensibile alla ouabaina che si ammette essere responsabile del trasporto di Na.
Experiments not reported in this paper show that ouabain 5×10–4 M does not enhance the ileal Na influx inhibition and also does not modify the Cl influx. Moreover ouabain 10–4 M affects jejunal Na influx to a less significant extent than 5×10–4 M. 相似文献
Experiments not reported in this paper show that ouabain 5×10–4 M does not enhance the ileal Na influx inhibition and also does not modify the Cl influx. Moreover ouabain 10–4 M affects jejunal Na influx to a less significant extent than 5×10–4 M. 相似文献
17.
Summary Five hybridomas secreting monoclonal antibody toE. coli L-asparaginase were isolated. These monoclonal antibodies were classified into 3 different subclasses; Ig G1 (1 clone), Ig G2 (2 clones) and Ig G3 (2 clones). One of them possessed anti-L-asparaginase neutralizing activity. Four antibodies examined demonstrated a linear Langmuir binding plot and binding affinities, with equilibrium dissociation constant (Kd) ranging between 2.5×10–9M and 6.3×10–10 M. The monoclonal antibodies should be useful probes for investigation of the enzyme activity. 相似文献
18.
G. Magni P. Ipata P. Natalini R. A. Felicioli G. Cercignani 《Cellular and molecular life sciences : CMLS》1974,30(8):861-862
Riassunio La citidina deaminasi, parzialmente purificata da lievito di pane, è capace di deaminare sia la citidina che la deossicitidina. I valori delleK
m
per ambedue i 2 substrati sono 25×10–5
M e 9.1×10–5
M rispettivamente. Inoltre l'enzima è inibito da numerosi nucleosidi monofosfati, difosfati e trifosfati. È molto significativa il tipo di inibizione allosterica esercitata dal dTTP. Si riporta una ipotesi sul ruolo metabolico della citidina deaminasi. 相似文献
19.
Resumen El fenilmentano sulfonil fluoro (FMSF) 4×10–5
M inhibe a la acetilcolinesterasa (E. C. 3.1.1.7) de cerebro de rata en más de 50%, y 9×10–4
M más de 90%. La constante de reacción inhibidor enzima es de 4.7×102 (1 mol–1 min–1). La colinesterasa (E. C. 3.1.1.8) de cerebro de rata es insensible a FMSF.
Supported by NIMH Grant No. 1 RO3 MH 19125, by Comisión Nacional de Investigación Cientiffica Proyecto No. 80, and by Comisión de Investigación Cientiffica Universidad de Chile, Proyecto No. 95. 相似文献
Supported by NIMH Grant No. 1 RO3 MH 19125, by Comisión Nacional de Investigación Cientiffica Proyecto No. 80, and by Comisión de Investigación Cientiffica Universidad de Chile, Proyecto No. 95. 相似文献
20.
C. G. Honegger L. M. Krepelka M. Steiner H. P. von Hahn 《Cellular and molecular life sciences : CMLS》1973,29(10):1235-1237
Zusammenfassung Die Kinetik der Aufnahme von S35-Taurin in Rattencortex-Schnittchen wird im Konzentrationsbereich von 9×10–8
M bis 5×10–3
M untersucht. Nach Abzug des Transportes durch Diffusion (K
D
×S) findet man einen Mechanismus, der Michaelis-Menten Kinetik folgt (v
sat
), mitK
m
=1,73×10–4
M. Ein solcher Transport liegt nicht im Bereich des spezifischen «uptake» der Neurotransmitter. Auch die sehr niedrige Aufnahme-Rate und die subzelluläre Verteilung nach «uptake» sprechen gegen eine Neurotransmitter-Funktion von Taurin. 相似文献