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On the subspecific origin of the laboratory mouse 总被引:11,自引:0,他引:11
The genome of the laboratory mouse is thought to be a mosaic of regions with distinct subspecific origins. We have developed a high-resolution map of the origin of the laboratory mouse by generating 25,400 phylogenetic trees at 100-kb intervals spanning the genome. On average, 92% of the genome is of Mus musculus domesticus origin, and the distribution of diversity is markedly nonrandom among the chromosomes. There are large regions of extremely low diversity, which represent blind spots for studies of natural variation and complex traits, and hot spots of diversity. In contrast with the mosaic model, we found that most of the genome has intermediate levels of variation of intrasubspecific origin. Finally, mouse strains derived from the wild that are supposed to represent different mouse subspecies show substantial intersubspecific introgression, which has strong implications for evolutionary studies that assume these are pure representatives of a given subspecies. 相似文献
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Foulkes WD 《Nature genetics》2008,40(1):8-9
Breast tumors with deficiency in DNA double-strand break repair might be expected to show aneuploidy. A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are signature lesions in these cancers, particularly those arising in BRCA1-mutation carriers. 相似文献
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McKie AT 《Nature genetics》2005,37(11):1159-1160
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McLean WH 《Nature genetics》2008,40(11):1270-1271
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Epigenetic inheritance at the agouti locus in the mouse. 总被引:21,自引:0,他引:21
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