食源性血管紧张素转化酶抑制肽的研究进展

血管紧张素转化酶(ACE)对于人体血压的调节起着十分重要的作用,食源性ACE抑制肽由蛋白质水解得到,其安全性比较高、无毒副影响,且易吸收、成本低,具有化学合成药物不可比拟的优越性,引起相关专家的重视。本文详尽阐述了食源性ACE抑制肽的降压机制、研究现状及其应用前景。     

水产胶原蛋白肽功能活性及其制备工艺研究进展

概述了水产胶原蛋白及其肽的特点和制备技术,并阐述了水产胶原蛋白肽的多种功能特性,包括抑制血管紧张素转化酶、抗氧化、免疫调节、抑制酪氨酸酶及其它活性,揭示了其在食品、化妆品及医药制备等领域的广阔应用前景.     

牛乳酪蛋白源ACE抑制肽的稳定性和毒理特性研究

研究目的：创新要点：研究方法：重要结论：酸碱热处理对牛乳酪蛋白源血管紧张素转化酶（ACE）抑制肽的抑制活性、游离氨基、色泽及其毒理特性的影响。在pn9.0-12．0的热处理条件下,牛乳酪蛋白源ACE抑制肽的抑制活性降低,色泽加深。热处理后的ACE抑制肽对Caco-2细胞和ECV-304细胞没有毒性作用。以ACE抑制活性、游离氨基、色差值和细胞存活率为检测指标,研究了酸碱热处理对ACE抑制肽的稳定性和毒理特性影响。高温和碱性热处理能破坏酪蛋白源ACE抑制肽的稳定性（见图1～3）。     

电性距离矢量(MEDV-B)用于58个血管紧张素转化酶(ACE)抑制剂二肽的结构表达

曾用β-受体阻滞剂治疗高血压,研究发现该类药物能减少肾素释放,目标始转肾素即血管紧张素系统试图获得更理想抗高血压药物.肾素是一种蛋白水解酶,可水解血管紧张素原,使Leu10-Val11肽键断裂为血管紧张素Ⅰ十肽,再在转化酶(ACE)作用下脱二肽转为血管紧张素Ⅱ八肽.     

条斑紫菜ACEI肽结构鉴定与性能试验

对条斑紫菜蛋白酶解获得的血管紧张素转换酶抑制肽(ACEI)进行纯化和结构鉴定,并研究了条斑紫菜ACEI肽体外贮存稳定性和对原发性高血压大鼠的降血压作用.结果表明:通过2步反相高效液相制备色谱纯化得到2种单一组分ACEI肽,经液质联用质谱分析肽序列分别为Cys-Ser-Asn-Arg和Pro-Cys-His-Trp,二者对血管紧张素转换酶半数抑制浓度分别为24.71和5.38 μmol·L-1;条斑紫菜ACEI肽不耐高温,在中性或酸性条件下较稳定;用分子质量小于3 ku条斑紫菜ACEI肽组分对原发性高血压大鼠灌胃后有显著降血压效果,且降血压幅度随灌胃剂量增大而提高.     

苍术提取物对血管紧张素转化酶的抑制活性

通过苍术提取物对血管紧张素转化酶抑制活性的有效成分或有效部位的分析研究,发现苍术残渣的抑制活性最强,其抑制率为95．91％;表明苍术残渣是苍术提取物对ACE的抑制活性部位,而指纹图谱是控制其品质的重要依据。     

血管紧张素转化酶的分光光度法测定及临床意义

血管紧张素转化酶（angiotensinconvertionenzyme,ACE．Peptidyldipeptida。;EC3．4．15．l）也叫漱酶Ⅱ。该回裂解血管紧张素1的C一末端的组氨酸一L一亮氨酸而产生8肽血管紧张素11。ACE是一种构成血管内皮细胞的膜性糖蛋白,属于内皮细胞的外分泌酶,在血管紧张素D的产生及援激肽的分解代谢中均起到关键性作用。近年来由于几项研究显示ACE基因可能参与了心血管疾病的发生而引起人们对此酶的兴趣。因此,建立一种灵敏准确的检测方法将会对心血管疾病的研究、早期诊断及预防均有重要价值。l测定方法1．l概述在以往报道的关于血清ACE…     

一种沙坦类降压新化合物的药理活性研究

目的对一种新型的血管紧张素II受体拮抗剂进行降压活性评价。方法采用放射性受体结合试验研究化合物对血管紧张素II受体的亲和性;采用无创尾动脉测压法进行动物体内降压活性研究。结果受试化合物对血管紧张素II具有很好的亲和性,其IC50值为3.55±0.11 n M,在动物体内显示出高效、长效的降压活性,最大降压值超过40 mm Hg。     

急性心肌梗塞与心钠素关系的探讨

<正>从发观心钠素(ANF)十年来,对其研究已有较深入的发展。ANF是人体心房肌细胞合成的一种肽类激素,具有多种生物活性,有强大的利钠利尿、扩血管、降血压和抑制肾素一血管紧张素醛固酮的作用。本文对急性心肌梗塞患者与健康人血浆心钠素浓度进行了对比观察。     

ACE基因插入／缺失（I／D）多态性及临床意义

血管紧张素转化酶（angiotensin—converting enzyme,ACE）通过肾素一血管紧张素系统RAS（retrain—angiotensin system）和激肽释放酶一激肽系统,调节血压体内的水电解质平衡以及血管内皮发育,其水平受遗传因素影响。ACE基因插入／缺失（L／D）多态性与血浆ACE水平密切相关,因而对高血压,冠心病等心脑血管疾病的发生发展具有重要影响。     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Design and analysis of generic LBS application developing platform

Location based services is promising due to its novel working style and contents.A software platform is proposed to provide application programs of typical location based services and support new applications developing efficiently. The analysis shows that this scheme is easy implemented, low cost and adapt to all kinds of mobile nework system.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that