Mass spectrometry in structural and stereochemical problems spegazzinine and spegazzinidine

Zusammenfassung Auf Grund von Protonresonanz und massenspektrometrischen Messungen werden die Strukturen III und VII für die Aspidosperma-Alkaloide Spegazzinidin und Spegazzinin vorgeschlagen.

---

---

This paper represents part III. For preceding paper seeB. Gilbert, J. Ferreira, R. J. Owellen, C. E. Swanholm, H. Budzikiewicz, L. J. Durham, andC. Djerassi, Tetrahedron Letters,1962, 59.

---

This paper represents Part VI in the La Plata seriesEstudios sobre Plantas; for paper V seeT. Nakano, C. Djerassi, R. A. Corral, andO. O. Orazi, J. org. Chem.26, 1184 (1961).     

Chemical constituents of the antibiotic fraction ofArnebia nobilis

Zusammenfassung Aus den Wurzeln vonArnebia nobilis wurden 4 antibiotisch wirksame Stoffe isoliert. Die Struktur von dreien wurde aufgeklärt.

---

---

On deputation from the Chemistry Department, Lucknow University.

---

To whom enquiries should be made. The isolation of shikonin monoacetate and,-dimethylacrylate fromLithosperm erythrorhizon, I.Morimoto, T.Kishi, S.Ikegana and Y.Hirata, Tetrahedron Lett.4737 (1965), has been brought to our notice since communicating this paper.

---

Communication No. 1305 from the Central Drug Research Institute.     

Oxygen consumption of genetically obese rats

Zusammenfassung Der Sauerstoffverbrauch genetisch fettleibiger Ratten ist auffallend niedriger als derjenige von Normalratten (littermates), die nach Hypothalamusverletzung fettleibig wurden.

---

---

J.Mayer, R. E.Russell, M. W.Bates and M. M.Dickie, Endocrinology56, 318 (1952).

---

The author thanks Dr. E. B.Astwood for his continuing support and encouragement.     

CMR spectral analysis of tetrahydrocannabinol and its isomers

Zusammenfassung Die¹³C-NMR-Spektren des Tetrahydrocannabinols und seiner Isomeren wurden aufgenommen und vollständig analysiert.

---

---

Carbon-13 Nuclear Magnetic Resonance Spectroscopy of Naturally Occurring Substances. IX. For the preceding article seeE. Wenkert, C.-J. Chang, D. W. Cochran andR. Pellicciari, Experientia28, paper No. 1099 (1972).

---

U.S. Public Health Service predoctoral fellow, 1967–1971.

---

U.S. Public Health Service predoctoral fellow, 1969–1972.     

Bazzanenol,a new sesquiterpene alcohol having a skeleton of Bicyclo[5.3.1] undecane system from hepaticae,Bazzania pompeana (Lac.) Mitt

Zusammenfassung Isolierung und Strukturaufklärung eines neuen Sesquiterpenalkohols ausBazzania pompeana (Lac.) Mitt.

---

---

Studies on chemical constituents from Hepaticae, Part III: S.Hayashi, A.Matsuo and T.Matsuura, Tetrahedron Letters,1969, 1599 and ref.² are regarded as Part I and II.     

Optical rotatory dispersion studies. Configurational assignments among the aporphine alkaloids

Résumé Les configurations absolues de certains alkaloïdes de l'aporphine ont été détérminées à partir de leurs courbes de dispersion rotatoire.

---

---

Paper LXII; paper LXI seeC. Djerassi, J. Fishman, andT. Nambara, Exper.17, 565 (1961).     

Synthetic peptides related to caerulein1. Note 1

Riassunto Vengono descritte le proprietà di una serie di peptidi sintetici affini alla ceruleina e si discutono brevemente i rapporti fra attività e struttura.

---

---

A. Anastasi, V. Erspamer andR. Endean, Experientia23, 699 (1967).

---

This work was in part supported by grants from the Consiglio Nazionale delle Ricerche, Roma.     

Nachweis von Scilliglaucosidin in den Zwiebeln vonBowiea volubilis Harvey

Summary Hellebrigenin was converted to Scilliglaucosidin-19-ol and 3-Epi-Scilliglaucosidin-19-ol. This proves the correctness of the assumption ofStoll et al. ³ that the aldehydic group of Scilliglaucosidin is in position C-10.Comparison of a reduction product of Nabogenin, a substance isolated earlier from the bulbs ofBowiea volubilis Harvey, with Scilliglaucosidin-19-ol and 3-Epi-Scilliglaucosidin-19-ol showed its identity with the first named compound. This proves that the so called Nabogenin was a mixture consisting mainly of Scilliglaucosidin.

---

---

8. Mitteilung über die Glykoside vonBowiea vocubilis Harvey und 162. Mitteilung über Glykoside und Aglykone.

---

7. Mitt.:A. Katz, Helv. chim. Acta38, 1565 (1955).

---

161. Mitt.:H. Kündig-Hegedüs undO. Schindler, Helv. chim. Acta39, 904 (1956).     

Sesquiterpenoids minor constituents ofPinus parviflora. On the relationship between (−)-δ-cadinol, (+)-δ-cadinol,sesquigoyol, torreyol,and brown alga cadinol

Zusammenfassung 1-Dokosanol, Sesquigoyol,-Sitosterin und 3,5-Dimethoxystilben wurden ausP. formosana isoliert. Es konnte gezeigt werden, dass Sesquigoyol der optische Antipode von (–)--Cadinol ist.

---

---

Sesquiterpenoids II. For the previous paper in this series, seeW. G. Dauben, B. Weinstein, P. Lim, andA. B. Anderson, Tetrahedron15, 217 (1961).

---

On leave of absence from the Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China.

---

The National Council of Science, Republic of China, is thanked for the award of a fellowship for advanced study to one of us (K.-T.W.).     

Synthesis of Seselin and its hydroderivatives

Zusammenfassung Die Synthese des Naturstoffes Tetrahydroseselin aus der FruchtSeseli indicum wird beschrieben.

---

---

Part X of a seriesCoumarins and Related Compounds. Part IX, A. K.Das Gupta, R. M.Chatterje and K. R.Das, J. chem. Soc. (C), (1969), 2618.     

Synthetic substitute enzymes: Part III glutamic acid copolymers with lysozyme-like activity

Zusammenfassung Synthetische Copolymere aus Glutaminsäure und Phenylalanin zeigen Lysozymaktivität. Mit einem Produkt Phe₉₀Glu₁₀ wurde ca. ein Drittel der Lysozymaktivität erreicht.

---

---

Communication No. 1415 from the Central Drug Research Institute. Part II — V. K.Naithani, K. B.Mathur and M. M.Dhar, Indian J. Biochem.6, 10 (1969).

---

To whom enquiries may be made.     

Activation of virus production by DMSO in C. albicans experimentally infected with polyoma-DNA

Zusammenfassung Die Infektion von Schimmelpilzen,C. albicans, durch Polyomavirus mit isolierter Polyoma-DNS und die aktivierende Wirkung von DMSO werden beschrieben.

---

---

Supported by a grant of the National Cancer Institute of Canada.

---

The assistance of Mr. G.Kolompár and B.Bucz during these assays is gratefully acknowledged.     

Über eine neue Synthese von 18-Hydroxy- und 18-Oxo-progesteron

Summary 18-Hydroxyprogesterone (VII) and the corresponding 18-aldehyde (IX), hitherto only accessible with difficulty from natural 18-substituted steroids, have been synthesized starting from progesterone.

---

---

Über Steroide, 188. Mitt.

---

187. Mitt. s.Ch. Meystre, K. Heusler, J. Kalvoda, P. Wieland, G. Anner undA. Wettstein, Helv. chim. Acta45, 1317 (1962).     

New dopamine receptor stimulant drug

Zusammenfassung Es wird der Nachweis erbracht, dass2(p-nitrobenzylthio)-Imidazolin (3H) · HCl (NBTI) Dopamin-Rezeptoren von Mäusen, Ratten und Affen direkt zu stimulieren vermag.

---

---

The authors wish to thank Dr.G. Ullyot, SKF Laboratories, for gifts of NBTI and chlorpromazine; Dr.H. Corrodi, AB Hässle, Göteborg, Sweden, for the methyl ester hydrochlorides ofl-Dopa,-methyl-p-tyrosine andp-chlorophenylalanine; McNeil Laboratories, Inc., Fort Washington, Pennsylvania, for the haloperidol; and Schering Corporation, Bloomfield New Jersey, for perphenazine. Thanks are also due toA. Schindler for his skillful technical assistance.

---

Final paper in press, Eur. J. Pharmac. (1972).     

The structures of five newAspidosperma alkaloids related to uleine

Zusammenfassung Aus der Rinde des brasilianischen BaumesAspidosperma dasycarpon A. DC. wurden fünf neue Alkaloide (II–VI) isoliert, die das selten vorkommende Uleinskelett besitzen. Die Strukturen wurden durch chemische Korrelation mit Ulein (I) sichergestellt.

---

---

Paper XLVII in the seriesAlkaloid Studies. For paper XLVI seeK. S. Brown Jr. andC. Djerassi, J. Am. chem. Soc.86, in press (1964).     

Terpenoid alkaloids fromMurraya koenigii Spreng. VII1 synthesis ofdl -O-Methylmahanine and related carbazoles

Zusammenfassung Die Synthese vondl-O-Methylmahanine wird beschrieben und damit die Struktur (IIa) für Mahanine bewiesen.

---

---

Part VI.S. P. Kureel, R. S. Kapil andS. P. Popli, Chemy Ind. 1262 (1970).

---

Communication No. 1640 from the Central Drug Research Institute, Lucknow.     

Voacanga-Alkaloide IV. Struktur von Voacryptin und Voacristin

Summary Voacryptine is demonstrated to be 20-oxovoacangine. On reduction, it furnishes voacristine (20-hydroxyvoacangine) and 20-epi-voacristine.

---

---

3. Mitt.U. Renner undD. A. Prins, Exper.15, 456 (1959).     

Rates of ethiodide formation and the stereochemistry of ajmaline at C-21

Résumé Les auteurs ont mesuré les vitesses de réaction entre l'ajmaline plus dérivés et l'iodure d'éthyle. Les conclusions stéréochimiques deTaylor au C-21 en ont été confirmées.

---

---

For previous papers on rates of quaternary iodide formation of alkaloids see (a)M. Shamma and J. B. Moss, J. Amer. chem. Soc.83, 5038 (1961) and (b)M. Shamma andE. F. Walker Jr., Chem. & Ind.1962, 1866.

---

Acknowledgments. The authors wish to thank Dr.W. I. Taylor of CIBA Pharmaceutical Company for the generous gift of the compounds used in this study, and the National Institutes of Health (Grant No. GM-10608-01) for financial assistance.     

Über Struktur und Aktivität der den H2O2-Zerfall katalysierenden Cu2+-Komplexe. — VI. Differenzierung von nativer RNS und nativer DNS bzw. denaturierter DNS auf Grund der katalytischen Eigenschaften

Summary The catalysis of H₂O₂ decomposition by Cu²⁺-complexes of RNA and DNA has been investigated. It is shown that both complexes decompose H₂O₂, but only the Cu²⁺-RNA-system shows peroxidative activity too, e.g. only in this case the nucleotide bases are degraded. Thermal denaturation of DNA also leads to a Cu²⁺-complex with peroxidative activity, the latter being dependent on the degree of denaturation.

---

---

V. Mitteilung:S. Petri, H. Sigel undH. Erlenmeyer, Helv. chim. Acta49, 1778 (1966).

---

12. Mitteilung überMetallionen und H ₂ O ₂; 11. Mitteilung:H. Ch. Curtius, P. Anders, R. Zell, H. Sigel undH. Erlenmeyer, Helv. chim. Acta49, 2256 (1966).