Philosophy in the trenches: from naturalized to experimental philosophy (of science)

Recent years have seen the development of an approach both to general philosophy and philosophy of science often referred to as ‘experimental philosophy’ or just ‘X-Phi’. Philosophers often make or presuppose empirical claims about how people would react to hypothetical cases, but their evidence for claims about what ‘we’ would say is usually very limited indeed. Philosophers of science have largely relied on their more or less intimate knowledge of their field of study to draw hypothetical conclusions about the state of scientific concepts and the nature of conceptual change in science. What they are lacking is some more objective quantitative data supporting their hypotheses. A growing number of philosophers (of science), along with a few psychologists and anthropologists, have tried to remedy this situation by designing experiments aimed at systematically exploring people’s reactions to philosophically important thought experiments or scientists’ use of their scientific concepts. Many of the results have been surprising and some of the conclusions drawn from them have been more than a bit provocative. This symposium attempts to provide a window into this new field of philosophical inquiry and to show how experimental philosophy provides crucial tools for the philosopher and encourages two-way interactions between scientists and philosophers.     

Laws of nature and natural laws

The relationship between conceptions of law and conceptions of nature is a complex one, and proceeds on what appear to be two distinct fronts. On the one hand, we frequently talk of nature as being lawlike or as obeying laws. On the other hand there are schools of philosophy that seek to justify ethics generally, or legal theory specifically, in conceptions of nature. Questions about the historical origins and development of claims that nature is lawlike are generally treated as entirely distinct from the development of ethical natural law theories. By looking at the many intersections of law and nature in antiquity, this paper shows that such a sharp distinction is overly simplistic, and often relies crucially on the imposition of an artificial and anachronistic suppression of the role of gods or divinity in the worlds of ancient natural philosophy. Furthermore, by tightening up the terms of the debate, we see that the common claim that a conception of ‘laws of nature’ only emerges in the Scientific Revolution is built on a superficial reading of the ancient evidence.     

Constructing dystopian experience: A Neurath-Cartwrightian approach to the philosophy of social technology

Social situations, the object of the social sciences, are complex and unique: they contain so many variable aspects that they cannot be reproduced, and it is even difficult to experience two situations that are alike in many respects. The social scientists' past experiences that serve as their background knowledge to intervene in an existent situation is poor compared to what a traditional epistemologist would consider ideal. A way of dealing with the variable and insufficient background of social scientists is by means of models. But, then, how should we characterize social scientific models? This paper examines Otto Neurath's scientific utopianism as an attempt to deal with this problem. Neurath proposes that social scientists work with utopias: broad imaginative plans that coordinate a multitude of features of a social situation. This notion can be used in current debates in philosophy of science because we notice that utopias, in Neurath's sense, are comparable to models and nomological machines in Nancy Cartwright's conception. A model-based view of science lays emphasis on the fact that scientists learn from the repeated operation of such abstract entities, just as they learn from the repetition of experiments in a laboratory. Hence this approach suggests an approximation between the natural and the social sciences, as well as between science and utopian literature. This is exemplified by analyzing the literary dystopia We, written by Yevgeny Zamyatin, to show that reasoning from and debating about utopian writings, even if fictional and pessimistic, creates phenomena of valuation, which are fundamental for constituting a background of experiences in the social sciences.     

Incredulity towards Lyotard: a critique of a postmodernist account of science and knowledge

Philosophers of science have paid little attention, positive or negative, to Lyotard’s book The postmodern condition, even though it has been popular in other fields. We set out some of the reasons for this neglect. Lyotard thought that sciences could be justified by non-scientific narratives (a position he later abandoned). We show why this is unacceptable, and why many of Lyotard’s characterisations of science are either implausible or are narrowly positivist. One of Lyotard’s themes is that the nature of knowledge has changed and thereby so has society itself. However much of what Lyotard says muddles epistemological matters about the definition of ‘knowledge’ with sociological claims about how information circulates in modern society. We distinguish two kinds of legitimation of science: epistemic and socio-political. In proclaiming ‘incredulity towards metanarratives’ Lyotard has nothing to say about how epistemic and methodological principles are to be justified (legitimated). He also gives a bad argument as to why there can be no epistemic legitimation, which is based on an act/content confusion, and a confusion between making an agreement and the content of what is agreed to. As for socio-political legitimation, Lyotard’s discussion remains at the abstract level of science as a whole rather than at the level of the particular applications of sciences. Moreover his positive points can be accepted without taking on board any of his postmodernist account of science. Finally we argue that Lyotard’s account of paralogy, which is meant to provide a ‘postmodern’ style of justification, is a failure.     

The human selenoproteome: recent insights into functions and regulation

Selenium (Se) is a nutritional trace mineral essential for various aspects of human health that exerts its effects mainly through its incorporation into selenoproteins as the amino acid, selenocysteine. Twenty-five selenoprotein genes have been identified in humans and several selenoproteins are broadly classified as antioxidant enzymes. As progress is made on characterizing the individual members of this protein family, however, it is becoming clear that their properties and functions are quite diverse. This review summarizes recent insights into properties of individual selenoproteins such as tissue distribution, subcellular localization, and regulation of expression. Also discussed are potential roles the different selenoproteins play in human health and disease.     

The murine complement regulator Crry: new insights into the immunobiology of complement regulation

Complement has an important role in inflammation and in the normal function of the immune system. Activated complement fragments have the capacity to bind and damage self-tissues. Cells from vertebrates express on their surface regulators of complement activation that protect them from the deleterious effects of cell-bound complement fragments. Abnormalities in these regulators of complement activation may participate in the pathogenesis of autoimmune diseases and inflammatory disorders. Murine Crry is one of these regulators that inhibits the activation of the third component of complement and protects self-tissues from complement-mediated damage. Experimental work on Crry has increased our understanding of the immunobiology of complement regulation and the potential role of complement and complement inhibitors in the development and treatment of human diseases. Received 13 June 2001; received after revision 12 July 2001; accepted 9 August 2001     

Experimental philosophy of biology: notes from the field

I use a recent ‘experimental philosophy’ study of the concept of the gene conducted by myself and collaborators to discuss the broader epistemological framework within which that research was conducted, and to reflect on the relationship between science, history and philosophy of science, and society.     

Lead into gold: the science of finding nothing

Scientists are always doing experiments or making observations that disappoint them. Most negative experiments are consigned to the file drawer. But in physics, lead is regularly transmuted into gold by treating a negative result as an upper limit—an observation of the maximum strength of the phenomenon under investigation. The logic and sociology of upper limits and the logic and sociology of positive results are different. I explore the difference through a case study in the physical sciences. In the conclusion I ask why social sciences only rarely translate their negative findings into successes.     

The spread of Tobacco mosaic virus infection: insights into the cellular mechanism of RNA transport

Interactions of plant cells with pathogens or other biotic or abiotic environmental factors can give rise to systemic defense responses that rely upon the cell-to-cell and systemic transport of specific signals. A novel type of systemic signaling was revealed by recent evidence indicating the existence of RNA species that travel cell to cell and through the vasculature. The most compelling evidence for intercellular and systemic transport of RNA in plants is provided by viroids and viruses that apparently use the endogenous transport machinery to spread infection. The cell to cell movement of plant viruses occurs through small pores in the cell wall known as plasmodesmata and depends on virus-encoded 'movement proteins'. This review summarizes current knowledge of Tobacco mosaic virus infection with emphasis on the mechanism by which this virus targets its RNA genome from sites of replication to plasmodesmata to achieve intercellular spread.     

Centromere nature of the chromosomes ofRanatra (Heteroptera)

Zusammenfassung Histologisch-cytologische Untersuchungen zeigen, dass die Chromosomen vonRanatra monozentrisch sind. Der Befund steht im Gegensatz zu Ergebnissen anderer Autoren an andern Heteroptera-Arten, die polyzentrische Chromosomen haben. Die Natur des Centromers ist also bei verschiedenen Arten der Heteropteren verschieden.     

Novel insights into the biology of interleukin-32

Interleukin (IL)-32 is known as a proinflammatory cytokine that is likely involved in several diseases, including infections, chronic inflammation, and cancer. Since the first report in 2005, IL-32 has been the subject of numerous studies to unravel the biological function of this molecule. For example, silencing of endogenous IL-32 in primary or cell lines of human origin consistently suppressed responses to Toll-like receptors. The protein folding structure of the six isoforms of IL-32 does not resemble that of any classical cytokine and as of this writing, a specific IL-32 receptor has not been identified. Instead, we propose a mechanism by which exposure to extracellular IL-32 or overexpression of the molecule results in binding to intracellular partners that influences functions such as gene expression, cell death, or survival. As such, this review offers insights into the role of IL-32 in several diseases, host defense, inflammation, immune function, and cancer. Finally, possibilities to target IL-32 in several diseases are proposed.     

Long-term incubation with mifepristone (MLTI) increases the spine density in developing Purkinje cells: new insights into progesterone receptor mechanisms

Cerebellar Purkinje cells (PC) physiologically reveal an age-dependent expression of progesterone with high endogenous concentrations during the neonatal period. Even if progesterone has been previously shown to induce spinogenesis, dendritogenesis and synaptogenesis in immature PC, data about the effects of progesterone on mature PC are missing, even though they could be of significant therapeutic interest. The current study demonstrates for the first time a progesterone effect, depending on the developmental age of PC. Comparable with the physiological course of the progesterone concentration, experimental treatment with progesterone for 24 h achieves the highest effects on the dendritic tree during the early neonate, inducing an highly significant increase in dendritic length, spine number and spine area, while spine density in mature PC could not be further stimulated by progesterone incubation. Observed progesterone effects are certainly mediated by classical progesterone receptors, as spine area and number were comparable to controls when progesterone incubation was combined with mifepristone (incubation for 24 h), an antagonist of progesterone receptors A and B (PR-A/PR-B). In contrast, an increase in the spine number and area of both immature and mature PC was detected when slice cultures were incubated with mifepristone for more than 72 h (mifepristone long-time incubation, MLTI). By including time-lapse microscopy, electron microscopic techniques, PCR, western blot, and MALDI IMS receptor analysis, as well as specific antagonists like trilostane and AG 205, we were able to detect the underlying mechanism of this diverging mifepristone effect. Thus, our results provide new insights into the function and signaling mechanisms of the recently described progesterone receptor membrane component 1 (PGRMC1) in PC. It is highly suitable that progesterone does not just induce effects by the well-known genomic mechanisms of the classical progesterone receptors but also acts through PGRMC1 mediated non-genomic mechanisms. Thus, our results provide first proofs for a previously discussed progesterone-dependent induction of neurosteroidogenesis in PC by interaction with PGRMC1. But while genomic progesterone effects mediated through classical PR-A and PR-B seem to be restricted to the neonatal period of PC, PGRMC1 also transmits signals by non-genomic mechanisms like regulation of the neurosteroidogenesis in mature PC. Thus, PGRMC1 might be an interesting target for future clinical studies and therapeutic interventions.     

Progesterone regulation of implantation-related genes: new insights into the role of oestrogen

Genomic profiling was performed on explants of late proliferative phase human endometrium after 24-h treatment with progesterone (P) or oestradiol and progesterone (17β-E₂+P) and on explants of menstrual phase endometrium treated with 17β-E₂+P. Gene expression was validated with real-time PCR in the samples used for the arrays, in endometrium collected from early and mid-secretory phase endometrium, and in additional experiments performed on new samples collected in the menstrual and late proliferative phase. The results show that late proliferative phase human endometrium is more responsive to progestins than menstrual phase endometrium, that the expression of several genes associated with embryo implantation (i.e. thrombomodulin, monoamine oxidase A, SPARC-like 1) can be induced by P in vitro, and that genes that are fully dependent on the continuous presence of 17β-E₂ during P exposure can be distinguished from those that are P-dependent to a lesser extent. Therefore, 17β-E₂ selectively primes implantation-related genes for the effects of P. H. Dassen, C. Punyadeera: These authors contributed equally. Received 18 December 2006; received after revision 6 February 2007; accepted 8 March 2007     

Reflections on Kant’s concept (and intuition) of space

In this paper, I investigate an important aspect of Kant’s theory of pure sensible intuition. I argue that, according to Kant, a pure concept of space warrants and constrains intuitions of finite regions of space. That is, an a priori conceptual representation of space provides a governing principle for all spatial construction, which is necessary for mathematical demonstration as Kant understood it.     

Molecular insights into the novel aspects of diatom biology

Diatoms are unicellular photosynthetic eukaryotes that are thought to contribute as much as 25% of global primary productivity. In spite of their ecological importance in the worlds oceans, very little information is available at the molecular level about the novel aspects of their biology. Recent advances, such as the development of gene transfer protocols, are now allowing the genetic dissection of diatom biology. Notable examples are advances in understanding the genetic basis for the silica-based bioinorganic pattern formation of their cell walls and for elucidating key aspects of diatom ecophysiology. The potentiation of current research will allow an evaluation of the use of diatoms to construct submicrometre-scale silicon structures for the nanotechnology industry and will reveal the molecular secrets underlying their ecological success. Received 29 March 2001; received after revision 31 May 2001; accepted 31 May 2001     

New insights into the molecular mechanisms of sperm-egg interaction

At the moment of insemination millions of mammalian sperm cells are released into the female reproductive tract in order to find a single cell – the oocyte. The spermatozoa subsequently ignore the thousands of cells they make contact with during their journey to the site of fertilisation, until they reach the surface of the oocyte. At this point, they bind tenaciously to the acellular coat, known as the zona pellucida, that surrounds the oocyte and initiate the chain of cellular interactions that will culminate in fertilization. These exquisitely cell- and species-specific recognition events are among the most strategically important cellular interactions in biology. Understanding the cellular and molecular mechanisms that underpin them has implications for diagnosis of the aetiology of human infertility and the development of novel targets for fertility regulation. Herein, we describe two models indicating the plethora of highly orchestrated molecular interactions underlying successful sperm zona binding and sperm oocyte fusion. Received 17 December 2006; received after revision 31 January 2007; accepted 16 March 2007     

Value-entanglement and the integrity of scientific research

Throughout much of the 20th century, philosophers of science maintained a position known as the value-free ideal, which holds that non-epistemic (e.g., moral, social, political, or economic) values should not influence the evaluation and acceptance of scientific results. In the last few decades, many philosophers of science have rejected this position by arguing that non-epistemic values can and should play an important role in scientific judgment and decision-making in a variety of contexts, including the evaluation and acceptance of scientific results. Rejecting the value-free ideal creates some new and vexing problems, however. One of these is that relinquishing this philosophical doctrine may undermine the integrity of scientific research if practicing scientists decide to allow non-epistemic values to impact their judgment and decision-making. A number of prominent philosophers of science have sought to show how one can reject the value-free ideal without compromising the integrity of scientific research. In this paper, we examine and critique their views and offer our own proposal for protecting and promoting scientific integrity. We argue that the literature on research ethics and its focus on adherence to norms, rules, policies, and procedures that together promote the aims of science can provide a promising foundation for building an account of scientific integrity. These norms, rules, policies, and procedures provide a level of specificity that is lacking in most philosophical discussions of science and values, and they suggest an important set of tasks for those working in science and values—namely, assessing, justifying, and prioritizing them. Thus, we argue that bringing together the literature on research ethics with the literature on science and values will enrich both areas and generate a more sophisticated and detailed account of scientific integrity.     

Symmetries and the philosophy of language

In this paper, I consider the role of exact symmetries in theories of physics, working throughout with the example of gravitation set in Newtonian spacetime. First, I spend some time setting up a means of thinking about symmetries in this context; second, I consider arguments from the seeming undetectability of absolute velocities to an anti-realism about velocities; and finally, I claim that the structure of the theory licences (and perhaps requires) us to interpret models which differ only with regards to the absolute velocities of objects as depicting the same physical state of affairs. In defending this last claim, I consider how ideas and resources from the philosophy of language may usefully be brought to bear on this topic.