Fibrinolytic activity of rat uterine fluid

Zusammenfassung Nach Abbindung des Rattenuterus wird bei relativ grosser individueller Streubreite ein fibrinolytisch hochaktives Sekret produziert. Die Aktivität wird durch einen in verschiedenen Konzentrationen vorhandenen Plasminogenaktivator, der vermutlich im Oberflächenepithel des Endometriums gebildet wird, verursacht.     

Triphasic intestinal reaction on adrenaline in the rat

Zusammenfassung Adrenalin bewirkt eine triphasische Reaktion am isolierten Rattenileum. Die Kontraktionsphase beruht wahrscheinlich auf Stimulierung der -Rezeptoren.     

Early changes of cyclic nucleotide levels in a mitogenic reaction in the rat mesentery

Summary By measuring simultaneously cAMP and cGMP we found a biphasic time course with regard to cGMP and the cGMP/cAMP ratio very early in a mitogenic reaction in vivo. This is a new finding.This work was supported by the Swedish Cancer Society and the Swedish Medical Research Council (project No. 04X-04498). We are indebted to Marcela Bartonek and Margareta Odenö for expert technical assistance and to Erik Leander for help with statistical matters.     

Early changes of cyclic nucleotide levels in a mitogenic reaction in the rat mesentery.

By measuring simultaneously cAMP and cGMP we found a biphasic time course with regard to cGMP and the cGMP/cAMP ratio very early in a mitogenic reaction in vivo. This is a new finding.     

Analysis of translation products synthesized in isolated rat hepatocytes treated with diethylnitrosamine

Isolated rat hepatocytes were labeled with 35S-methionine in the presence of 25 mM diethylnitrosamine (DENA). The intrinsically labeled proteins were analyzed by one- and two-dimensional gel electrophoresis and the fluorographic patterns were compared with those obtained from untreated hepatocytes. The results of short term experiments (2 h) show that, in the presence of 25 mM DENA, protein synthesis is inhibited by 50%. This reduction encompasses all protein species without selective inhibition of certain proteins.     

Analysis of translation products synthesized in isolated rat hepatocytes treated with diethylnitrosamine

Summary Isolated rat hepatocytes were labeled with³⁵S-methionine in the presence of 25 mM diethylnitrosamine (DENA). The intrinsically labeled proteins were analyzed by one-and two-dimensional gel electrophoresis and the fluorographic patterns were compared with those obtained from untreated hepatocytes. The results of short term experiments (2 h) show that, in the presence of 25 mM DENA, protein synthesis is inhibited by 50%. This reduction encompasses all protein species without selective inhibition of certain proteins.This work was supported by CNR (Project Control of Neoplastic Growth) grant No. 810132696 and partially by AIRC.     

Hepatic regeneration in the rat after subtotal (90%) hepatectomy treated with testosterone

A single dose (120 mg/kg IM) of testosterone administered 1 month before subtotal hepatectomy (90%) in Rats, reduced liver steatosis and allowed complete liver regeneration.     

Effect of various doses of catecholestrogens on uterine eosinophilia in the immature rat

Summary This paper describes the induction of uterine eosinophilia as well as of deep endometrial edema and increase of uterine wet weight in the immature rat by the catecholestrogens 2-OH-estradiol and 4-OH-estradiol. These effects are thought to be mediated by eosinophils via a specific eosinophil receptor system. 4-OH-estradiol was equipotent with estradiol, whereas the effect of 2-OH-estradiol was significantly weaker.Acknowledgments. This work was supported by Grant B-1493-8435 from the University of Chile. We are indebted to Prof. R. Knuppen, Lübeck, for providing the CE.     

The effect of oestradiol-17 β on uterine adenosine triphosphatase in the rat

Zusammenfassung ATPase-Aktivitätsmessungen im Uterus der Ratte nach 17-Oestradiol ergeben ein relativ differenziertes Wirkmuster für dieses Steroid.     

Effect of various doses of catecholestrogens on uterine eosinophilia in the immature rat

This paper describes the induction of uterine eosinophilia as well as of deep endometrial edema and increase of uterine wet weight in the immature rat by the catecholestrogens 2-OH-estradiol and 4-OH-estradiol. These effects are thought to be mediated by eosinophils via a specific eosinophil receptor system. 4-OH-estradiol was equipotent with estradiol, whereas the effect of 2-OH-estradiol was significantly weaker.     

Uterine glucose metabolism in the prepubertal rat treated neonatally with androgen,estrogen, and antihormones

Summary Estrogen secretion during infancy may selectively enhance the phosphogluconate oxidative pathway in the rat uterus, for altered estrogen-stimulated glucose oxidation prepubertally is correlated (+0.91) with impaired ovarian development and not uterine estrogen receptor content.This work was supported in part by NSF Research Grant PCM-8409586.     

Uterine glucose metabolism in the prepubertal rat treated neonatally with androgen, estrogen, and antihormones

Estrogen secretion during infancy may selectively enhance the phosphogluconate oxidative pathway in the rat uterus, for altered estrogen-stimulated glucose oxidation prepubertally is correlated (+0.91) with impaired ovarian development and not uterine estrogen receptor content.