Measurement of associations between mobile calls and mobile-internet surfing

Measuring mobile calls data is an increasingly import issue,which will benefit to the understanding of the behavior of mobile users and assist telecom operators to optimize their business strategies.The existing researches on cell phone data measurement only focus on mobile calls or on mobile-internet surfing and little researches focus on the interactions of behaviors between them.In this paper,some basic factors of the association between mobile calls and mobile-internet surfing are measured.Then first their distributions are compared and the preference of users is quantified.After that experiments on the curve fitting of both the whole and parts of these distributions are done.Through the comparison of the correlation coefficients and Fourier fitting parameters,different behaviors is found between workdays and weekends,as well as Saturdays and Sundays in mobile-call distributions.Besides,the results of our observation show that the mobile-internet traffic does not always monotone increase with the increase of online time,significant changes are observed after 8hours of mobile-internet surfing.     

Indirect associations between multiple items and a mining algorithm

hldirect association is a high level relationship between items and frequent itemsets in data. Current research approaches on indirect association mining are limited to indirect association between itempairs,which will discover too many rules from dataset. A formal definition of indirect association between multiple items is presented, along with an algorithm, SET NIA, for mining this kind of indirect associations based on anti-monotonicity of indirect associations and frequent itempair support matrix. While the found rules contain same information as compared to the rules found by indirect association between itempairs algorithms, this notion brings space-saving in storage of the rules as well as superiority for human to understand and apply the ndes. Experiments conducted on two real-word datasets show that SET _ NIA can effectively find fewer rules than existing algorithms which mine indirect association between itempairs,the experimental results also prove that SET_NIA has better performance than existing algorithms.     

Meta-Analysis on the associations between Prenatal Perfluoroalkyl Substances Exposure and Adverse Birth Outcomes

The epidemiological associations between the prenatal perfluoroalkyl substances(PFASs) exposure and the reproductive outcomes remain controversial. A continuous evaluation is needed to combine the inconsistent results. In this study, we explored the associations between PFASs exposure and the low birth weight(LBW), preterm birth and small for gestational age(SGA). The quality of selected literature, quantitative estimates, publication bias and subgroup analysis were performed on the basis of 17 retrieved articles published before December 2020. The results showed a significant positive association between the perfluorooctane sulfonate(PFOS) exposure and the risk of LBW [Odds ratio(OR)=1.17; 95% confidence interval(CI): 1.01, 1.36; heterogeneity: P=0.30, I~2=17%]. The positive association was also observed between the PFOS and the risk of preterm birth(OR=1.19; 95% CI: 1.01, 1.39, P=0.007; I~2=62%). There was a paucity of evidence regarding the negative effects of perfluorooctanoic acid(PFOA), perfluorohexanesulfonic acid(PFHxS) and perfluorononanoic acid(PFNA) on the pregnancy outcomes. The findings from the subgroup analysis(the sampling period, the birth gender and biologic specimens) did not substantially altered the results of the overall pooled estimate ORs. The increased prevalence of negative birth outcomes with gestational PFASs exposure warrants further explorations from biological process perspective.     

Genetic overlap between salt and low-temperature tolerance loci at germination stage of soybean

Salt and low temperature was both very important factors for soybean production. It was necessary to improve the salt stress and low temperature tolerance of soybean. The main purpose of this paper was to map the QTLs related with salt tolerance and low-temperature tolerance at germination stage with backcross introgression lines (ILs), and analyze the genetic overlap between them. There were 22 QTL located with BC2F4 introgression populations after salt stress, and 15 QTL were mapped after low-temperature stress. Seven overlapping QTLs between salt tolerance and low-temperature tolerance were detected on 6 linkage groups at germination stage. In total, there were 31.81% of salt tolerance and low-temperature tolerance loci existed genetic overlap.     

J油田水气交替驱开发效果评价

利用油藏数值模拟技术,采用单因素分析方法研究了井网形式、注采井距、注气时机、注气速度、水气交替注入周期、气水比对J油田水气交替驱开发效果的影响,并比较了水驱、气驱及水气交替驱的开发效果;基于QIM-AG算法,对比了水驱、气驱和水气交替驱的经济开发效益。结果表明:注气速度、气水比、注水时机对采出程度影响较大,而井距、注入周期对采出程度影响相对较小;较高的注气速度(0.08HCPV/a)、压力保持程度为1、小井距、气水体积比为1.5∶1、注入周期为3个月时可获得较高的采出程度;在注入气水总体积相同的条件下,气水交替驱比单纯水驱或气驱可获得更高的最终采收率,且具有更大的开发净现值。     

Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR beta loci

Class II molecules encoded by the human major histocompatibility complex (MHC) are involved in regulating T-cell response to antigens. The mechanisms for generating polymorphism in products of the MHC have been studied extensively for both the murine H-2 and the human HLA complex. Such studies indicate that point mutations plus selection have a major role in the generation of polymorphisms of class I and class II MHC genes. However, a non-reciprocal gene conversion mechanism has been proposed to explain several examples of clustered sequence variation in MHC genes. In all these examples, the proposed gene conversion event is unidirectional; that is, one of the two interacting genes acts as sequence donor and the other as sequence recipient. No examples of potential reciprocal genetic exchange (as occurs in the fungal system), in which the two interacting genes act as both donor and recipient of gene fragments, have been found in the MHC system or in other multigene families of higher organisms. We sequenced two different HLA-DR beta complementary DNAs from each of two different cells all expressing the same serologically defined determinant (DR2) but different T-cell-recognized (Dw) specificities (Dw12 and MN2). Sequence comparisons of these four cDNA clones (and two DR beta amino-acid sequences from the DR2-Dw2 subtype) suggest that new coding sequences for DR beta molecules in the DR2 haplotypes are potentially generated by reciprocal intergenic exchange.     

新疆锡伯族与哈萨克族间3个STR位点的多态性比较

分别获得CSF1PO,TPOX和TH013个短串联重复序列STR,对新疆锡伯族和哈萨克族人群中等位基因频率、基因型频率及相关法医学数据进行比较。应用PCR技术、4%变性聚丙烯酰胺凝胶电泳及银染技术对上述3个STR位点分型。锡伯族人群CSF1PO位点有9个等位片段,TPOX位点有8个等位片段,TH01位点有8个等位片段;哈萨克族人群CSF1PO位点有8个等位片段,TPOX位点有8个等位片段,TH01位点有7个等位片段,两民族各自的3个STR位点的基因型分布均符合Hardy-Weinberg平衡;锡伯族人群各位点杂合度分别为0.9426,0.8361,0.8853,多态信息量分别为0.8298,0.7213,0.7626;哈萨克族人群各位点杂合度分别为0.8753,0.8777,0.9321,多态信息量分别为0.7401,0.7568,0.7509。以上3个STR位点的基因频率分布在两个不同的人群中具有显著的差异。     

吉非替尼与紫杉醇合用于胃癌细胞的实验研究

联合应用靶向ErbB1的抗肿瘤药吉非替尼与传统化疗药紫杉醇,观察ErbBs高表达胃癌细胞的生长抑制作用及对ErbBs的影响.采用MTT法检测两药不同比例联合应用时对ErbBs高表达胃癌细胞的抑制作用,在此基础上通过计算CI值（Combination Index Value）,考察两药合用于ErbBs高表达胃癌细胞株时的相互作用关系（协同,相加或拮抗）.发现在两药浓度比例为330∶1,联合抑制率在60%~80%时,能够协同抑制ErbBs高表达胃癌细胞.并进一步探讨其可能的机制,通过Western Blot法检测药物作用对ErbBs,磷酸化ErbBs以及下游信号通路中（如PI3K-Akt信号途径）信号分子（Akt/磷酸化Akt）表达的影响.最终导致细胞死亡增多,通过DNAladder、Hochest33342染色、及检测凋亡相关蛋白的表达情况进一步确证协同促进细胞凋亡的作用.结果表明两药适宜配比可协同抑制ErbBs高表达胃癌细胞.     

Host-parasitoid associations in patchy environments

Studies of insect host-parasitoid interactions have contributed much to the consensus that spatial patchiness is important in the regulation of natural populations. A variety of theoretical models predict that host and parasitoid populations, although unstable in the absence of environmental heterogeneity, may persist at roughly steady overall densities in a patchy environment owing to variation in levels of parasitism from patch to patch. Observed patterns of parasitism, however, have a variety of forms (with variation in attack rates among patches depending directly or indirectly on host density, or showing variation uncorrelated with host density). There is some confusion about the dynamical consequences of these different forms. Here we first show how the dynamical effects of all these forms of environmental heterogeneity can be assessed by a common criterion. This 'CV2 greater than 1 rule' states that the overall population densities will remain roughly steady from generation to generation if the coefficient of variation squared (CV2) of the density of searching parasitoids in the vicinity of each host exceeds approximately unity. By partitioning CV2 into components, we show that both direct and inverse patterns of dependence on host density, and density-independent patterns, all contribute to population regulation in the same way. Second, we show how a maximum-likelihood method can be applied to the kind of field data that are usually available (that is, percentage parasitism versus local host density) to estimate the components of CV2. This analysis indicates that heterogeneity is large enough to stabilize dynamics in 9 of 34 published studies, and that density-independent heterogeneity is the main factor in most cases.     

济宁青山羊大小猾子皮的差异表达基因研究

以差异显示PCR（DDRT PCR）技术研究了小猾皮（出生3?d内）和大猾皮（出生30～60?d）的差异表达基因,并以反Northern点杂交技术快速剔除假 阳性条带。从40对随机引物中筛选出8对引物组合,其在2种猾子皮中共扩增出482条cDNA片段,其中差异表达条带为52条,占总条带数的10.79％。在所发现的差异条带中有41条为表达“强与弱”的差异 带,占总条带数的8.51％;另有11条为表达“有或无”的差异条带,占总条带数的2.28％。说明与小猾皮相比,大猾皮皮肤组织中有8.51%的基因增强或减弱表达,有2.28％的基因启动或关闭表达。这些 差异表达的基因是大猾皮和小猾皮花纹品质差异的遗传基础。