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1.
Summary Daily administration of vitamin D3 (75,000 IU/kg b.wt) for 7 days acceleratedTrichinella spiralis cyst calcification in rats with a 14-week-old infection. When disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) was administered (50 mg/kg b.wt) from 2 days before until 2 days after vitamin D3 treatment, cyst calcification was inhibited. Thus, the ability to inhibitT. spiralis calcification has been demonstrated for the first time.Supported in part by EKU faculty research grant No. 03-05.Much appreciation goes to Dr Gordon S. Hassings and the Proctor and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio USA for providing the EHDP used in this study. 相似文献
2.
Y. Fujimoto N. Ikekawa M. Ogiso E. Ohnishi 《Cellular and molecular life sciences : CMLS》1986,42(5):567-568
Summary The structures of the metabolites formed upon incubation of 17-estradiol with the ovaries of silkworm,Bombyx mori, have been determined as 17-estradiol 3-(-D-glucopyranoside) (1) and 17-(-D-glucopyranoside) (2) by spectroscopic means. 相似文献
3.
Summary A newly discovered third class of sensillum trichodea on the antenna ofTrichoplusia ni contains an olfactory receptor neuron that responds to (Z)-9-tetradecen-1-ol acetate at 1×10–18 M. The threshold of this neuron is 100–1000 times lower than the thresholds of two previously described pheromone-sensitive neurons that detect (Z)-7-dodecen-1-ol acetate and (Z)-7-tetradecen-1-ol acetate. The sensitivity and selectivity of this receptor neuron is evidence that (Z)-9-tetradecen-1-ol acetate may be important for sexual behavior. 相似文献
4.
J. Zemann 《Cellular and molecular life sciences : CMLS》1948,4(2):66-67
Summary The space-group of Cu(NH3)4SO4·H2O isD
2h
16
orD
2h
13
(D
2h
5
, D
2h
1
) with a=7,07, b=12,12, c=10,66 Å ± 1%. 相似文献
5.
P. S. Beevor D. R. Hall R. Lester R. G. Poppi J. S. Read B. F. Nesbitt 《Cellular and molecular life sciences : CMLS》1975,31(1):22-23
Zusammenfassung Es wurden mit gas-chromatographischer Elektroantennogramm-Methode (Z)-9-tetradecenyl-1-acetat und (Z)-9, (E)-12-tetradecadienyl-1-acetat als die Sexuallockstoffe weiblicherSpodoptera exempta (Wlk.) identifiziert.
Acknowledgment: We are grateful to Mr.C. Rivers, Unit of Insect Virology, University of Oxford Field Station, for supplying insect pupae. 相似文献
Acknowledgment: We are grateful to Mr.C. Rivers, Unit of Insect Virology, University of Oxford Field Station, for supplying insect pupae. 相似文献
6.
J. Schaller U. Kämpfer S. Schürch L. Kuhn-Nentwig S. Haeberli W. Nentwig 《Cellular and molecular life sciences : CMLS》2001,58(10):1538-1545
CSTX-9 (68 residues, 7530.9 Da) is one of the most abundant toxic polypeptides in the venom of the wandering spider Cupiennius salei. The amino acid sequence was determined by Edman degradation using reduced and alkylated CSTX-9 and peptides generated by
cleavages with endoproteinase Asp-N and trypsin, respectively. Sequence comparison with CSTX-1, the most abundant and the
most toxic polypeptide in the crude spider venom, revealed a high degree of similarity (53% identity). By means of limited
proteolysis with immobilised trypsin and RP-HPLC, the cystine-containing peptides of CSTX-9 were isolated and the disulphide
bridges were assigned by amino acid analysis, Edman degradation and nanospray tandem mass spectrometry. The four disulphide
bonds present in CSTX-9 are arranged in the following pattern: 1-4, 2-5, 3-8 and 6-7 (Cys6-Cys21, Cys13-Cys30, Cys20-Cys48, Cys32-Cys46). Sequence comparison of CSTX-1 with CSTX-9 clearly indicates the same disulphide bridge pattern, which is also found in
other spider polypeptide toxins, e.g. agatoxins (ω-AGA-IVA, ω-AGA-IVB, μ-AGA-I and μ-AGA-VI) from Agelenopsis aperta, SNX-325 from Segestria florentina and curtatoxins (CT-I, CT-II and CT-III) from Hololena curta. CSTX-1/CSTX-9 belong to the family of ion channel toxins containing the inhibitor cystine knot structural motif. CSTX-9,
lacking the lysine-rich C-terminal tail of CSTX-1, exhibits a ninefold lower toxicity to Drosophila melanogaster than CSTX-1. This is in accordance with previous observations of CSTX-2a and CSTX-2b, two truncated forms of CSTX-1 which,
like CSTX-9, also lack the C-terminal lysine-rich tail.
Received 23 July 2001; accepted 31 July 2001 相似文献
7.
Summary Laboratory-reared males ofHeliothis virescens (F.) that were released in olfactometers in the laboratory were attracted to theH. virescens synthetic pheromone, but not to (Z)-9-tetradecen-1-ol formate (Z-9-TDF), or to either pheromonal component, (Z)-11-hexadecenal (Z-11-HDAL) or (Z)-9-tetradecenal (Z-9-TDAL). Also, they did not respond to the pheromone when it was dispersed simultaneously with Z-9-TDF. The proximity of the test chemicals in the olfactometer made little, if any, difference in the response ofH. virescens males to the pheromone source. Preexposure to the synthetic pheromone, Z-9-TDF, Z-11-HDAL, or Z-9-TDAL greatly reduced the number ofH. virescens males responding to the pheromone. This reduction was probably caused by habituation of the moths to these chemicals.The authors wish to thank A. H. Baumhover, E. Hart and other personnel of the Tobacco Research Laboratory, Oxford, N. C., for supplying many of the insects used in these studies. 相似文献
8.
Two major functions of the Golgi apparatus (GA) are formation of complex glycans and sorting of proteins destined for various
subcellular compartments or secretion. To fulfill these tasks proper localization of the accessory proteins within the different
sub-compartments of the GA is crucial. Here we investigate structural determinants mediating transition of the two glycosyltransferases
β-1,4- galactosyltransferase 1 (gal-T1) and the α-1,3-fucosyltransferase 6 (fuc-T6) from the trans-Golgi cisterna to the trans-Golgi network (TGN). Upon treatment with the ionophore monensin both glycosyltransferases are found in TGN-derived swollen
vesicles, as determined by confocal fluorescence microscopy and density gradient fractionation. Both enzymes carry a signal
consisting of the amino acids E5P6 in gal-T1 and D2P3 in fuc-T6 necessary for the transition of these glycosyltransferases from the trans-Golgi cisterna to the TGN, but not for their steady state localization in the trans-Golgi cisterna.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
Received 30 July 2008; received after revision 17 September 2008; accepted 29 September 2008 相似文献
9.
M. Goldstein L. S. Freedman M. Bonnay 《Cellular and molecular life sciences : CMLS》1971,27(6):632-633
Zusammenfassung Eine isotopische Methode zur Bestimmung der DH-Aktivität wird beschrieben. Die Methode wurde verwendet zur Bestimmung der DH-Aktivität im menschlichen Serum und in verschiedenen Organen der Ratte. Das sympatische Nervensystem des Menschens kann mit dieser Methode weiter erforscht werden.
This work was supported by USPHS Grant No. 5 R01 MH-02717-12. 相似文献
This work was supported by USPHS Grant No. 5 R01 MH-02717-12. 相似文献
10.
Summary (1) A response ofZea mays andPisum roots cultured aseptically to 2,4-dichlorophenoxyacetic acid has been observed.Depending on the concentrationZea mays shows an increase of the growth rate (optimal concentration 10–11 mol) which turns over to an inhibition (above 10–7 mol). The curve is similar to that obtained by 3-indoleacetic acid, which proves the phytohormonal character of 2,4-D.(2) ThePisum root is more sensitive than theZea mays root. A concentration of 10–7 molinhibitsPisum in a high degree, whileZea mays is no more inhibited, thus demonstrating the selective herbicidal action of 2,4-D against isolated roots of Dicotyledons culturedin vitro. 相似文献
11.
M. Morea 《Cellular and molecular life sciences : CMLS》1985,41(11):1381-1384
Summary A gustatory mutant ofDrosophila melanogaster insensitive to the taste of salt has been isolated. Genetic crosses and a deletion mapping analysis show that this mutation, designatedgust-M
1 is located in the 93C3–6-93D6–7 region of the third chromosome.gust-M
1 is also insensitive to the taste of quinine sulfate. The behavior of this mutant may be explained by assuming thatgust-M
1 could be a mutation perturbing functions in the central nervous system affecting the responses to both compounds. 相似文献
12.
G. P. Mueller 《Cellular and molecular life sciences : CMLS》1962,18(6):253-254
Zusammenfassung Die Beweggründe für den Gebrauch derD- undL-Konvention in der Nomenklatur der Steroid-Sapogenine sowie ihre Anwendung auf die Konfigurationsanalyse und Formelaufstellung werden diskutiert. 相似文献
13.
S. Tahara S. Kasai M. Inoue J. Kawabata J. Mizutani 《Cellular and molecular life sciences : CMLS》1994,50(2):137-141
In a survey of antifungal stress compounds induced by cupric chloride we found that leaves ofChenopodium album exuded a highly fungitoxic metabolite mucondialdehyde (trans-2,trans-4-hexadienedial), which was associated with 13-oxo-9,11-tridecadienoic acids (cis-9,trans-11 andtrans-9,trans-11 isomers) presumably resulting from -scission of 13-hydroperoxy-octadecadi(tri)enoic acid. The biogenesis and role as a general defensive agent in plants are briefly discussed. 相似文献
14.
Summary The normalized diameter (D/D13.3 where D13.3 equals D at 13.3 kPa under control conditions) was measured at selected pressure levels under different hemodynamic conditions. Hemorrhage caused the normalized diameter to decrease (–3.3%) when compared to control values at a given pressure. Volume expansion anda-blockade with phenoxybenzamine caused D/D13.3 to increase (+3.3% and +8.5% respectively).This work was supported in part by PHS grant HL-23239 and a grant from the Central Ohio Heart Chapter of the American Heart Association. To whom reprint request should be addressed. 相似文献
15.
H. Arn P. M. Guerin H. R. Buser S. Rauscher E. Mani 《Cellular and molecular life sciences : CMLS》1985,41(11):1482-1484
Summary Pheromone glands and effluvia of the codling moth female containE-8, E-10-dodecadien-1-ol as main component, accompanied by its geometric isomers, the corresponding acetate and aldehyde (both in gland extracts only),E-9-dodecen-1-ol and saturated alcohols of 10 to 18 carbons. Dodecan-1-ol as the most abundant secondary component (about 30% of the female blend) acts in the wind tunnel by widening the dose range over which codling moth males are optimally attracted toE-8, E-10-dodecadien-1-ol.This research was supported by the Swiss National Science Foundation. We thank W. Riggenbach for supplying moths and T. Wildbolz, P. Charmillot and M. Tóth for conducting field trials. 相似文献
16.
S. J. Won Y. C. Chuang W. T. Huang H. S. Liu M. T. Lin 《Cellular and molecular life sciences : CMLS》1995,51(4):343-348
The effects of dopaminergic receptor inhibitors such as thiothixine (D1/D2), fluphenazine (D1/D2), trifluoperazine (D1/D2), pimozide (D2), flupenthixol (D1/D2), (+/–)-SKF 83566 (D1), and spiperone (D2) on splenic natural killer (NK) cell cytotoxic activities were assessed in vitro using mouse spleen lymphocytes or enriched NK cells. Both the activities of the splenic NK cell cytotoxicity and the effector-target cell conjugation were suppressed by thiothixine, fluphenazine, and trifluoperazine at concentrations from 2.64 to 14.78 M. In addition, the augmentation of the cytolytic activity of NK cells induced by interferon- or interleukin-2 was antagonized by pretreatment with these neuroleptic compounds. However, neither the splenic NK cell cytotoxicity nor the effector-target cell conjugation were affected by treatment with other neuroleptic compounds such as pimozide, flupenthixol, (+/–)-SKF 83566, and spiperone. Thus, it appears that neuroleptic compounds such as thiothixine, fluphenazine, and trifluoperazine may act through the mechanisms other than a dopaminergic pathway to affect the NK cell-target cell interaction. 相似文献
17.
Summary Leaves ofVitex agnus castus L. and of related species which are said to have hormonelike activities contain three flavonoids: casticin and luteolin-7-D-glucoside and aD-glucoside of an unknown 5-hydroxy-flavone derivative. 相似文献
18.
E. Arsura A. Capizzi P. Piccardi Pia Spinelli 《Cellular and molecular life sciences : CMLS》1977,33(11):1423-1424
Summary Field studies have shown that a combination of (Z)-9-tetradecenol with (Z)-9-tetradecenyl acetate is an effective attractant for maleSesamia cretica Led., a pest of sorghum crops. These studies also indicated that the most effective composition is 7525 (alcohol:acetate).We thank Dr E. Berio for the insect determination. 相似文献
19.
Š. Bauer O. Bauerová L. Masler D. Šikl 《Cellular and molecular life sciences : CMLS》1962,18(10):441-441
Summary By application of the counter-current method on extracts ofErysimum canescens Roth, four new crystalline glycosides have been isolated besides of Helveticoside and Erysimoside. The structure of one of them, named Erycanoside, has been determined as Strophanthidin--2-desoxy-D-glucosido-glucoside. 相似文献
20.
C. G. Honegger L. M. Krepelka M. Steiner H. P. von Hahn 《Cellular and molecular life sciences : CMLS》1973,29(10):1235-1237
Zusammenfassung Die Kinetik der Aufnahme von S35-Taurin in Rattencortex-Schnittchen wird im Konzentrationsbereich von 9×10–8
M bis 5×10–3
M untersucht. Nach Abzug des Transportes durch Diffusion (K
D
×S) findet man einen Mechanismus, der Michaelis-Menten Kinetik folgt (v
sat
), mitK
m
=1,73×10–4
M. Ein solcher Transport liegt nicht im Bereich des spezifischen «uptake» der Neurotransmitter. Auch die sehr niedrige Aufnahme-Rate und die subzelluläre Verteilung nach «uptake» sprechen gegen eine Neurotransmitter-Funktion von Taurin. 相似文献