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Conclusions The decrease of circulating blood volume, resulting in oligemic hypotension, may evoke in anaesthetized cat the active constrictory coronary vessel responses of 2 types, one occuring immediately after start of the hypotension and the other having a significantly prolonged latency.
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Laboratory of Biological Investigations.

Laboratory for Chemistry of Antibiotics.  相似文献   

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Summary [1-N4-Dimethyl-asparagine]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue gave rat blood pressure about 70% relative potency to Hypertensin (Ciba). Rabbit aorta strips gave intrinsic activity E=1, a PD2 of 6.92±0.09 and an affinity relative to [Asn1]-angiotensin II of 6.5%.The editors do not hold themselves responsible for the opinions expressed in the authors' brief reports. — Les auteurs sont seuls responsables des opinions exprimées dans ces brèves communications. — Für die Kurzmitteilungen ist ausschliesslich der Autor verantwortlich. — Per le brevi comunicazioni è responsabile solo l'autore. — . — Solo los autores son responsables de las opiniones expresadas en estas comunicationes breves.Acknowledgment. The authors wish to express their appreciation to Dr Emanuel Escher, School of Medicine, Centre Hospitalier Universitaire, Sherbrooke, Quebec, for his help in providing the biological data and critical comments.  相似文献   

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-Spermophilus brunneus . , 13 18 ,S. brunneus S. townsendii mollis (2n=38) , , ; ;S. brunneus . S. brunneus , Spermophilus.

Supported by National Science Foundation Grants No. GB32114X and No. GB 29131X, and the Sprague Foundation. We thankD. Pozin for technical assistance.  相似文献   

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Summary Kinetics studies of haemolymph -glucosidase inhibition by D. glucose led to general correlations between inhibition and control parameters, all over the honeybee development. Maximum velocities are not affected by the inhibition, while affinity constants are always significantly increased, and Hill coefficients tend to decrease, especially in foraging adults and in prenymphs. In this later case, the n-type effect tends to break the manifestation of the K-type mechanism.  相似文献   

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This work was supported by a Rackham Grant from the University of Michigan.  相似文献   

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Summary The rate of development of Ruhemann's purple in the ninhydrin reaction of two deuterated primary amines, -d2-p-tyramine and -d2--phenylethylamine, is significantly reduced It appears to be a primary isotope effect and indicates that the cleavage of the carbon-hydrogen bond at the -position is involved in the rate-determining step of the color reaction.Acknowledgements. We thank Dr A.A. Boulton for his advice and encouragement and the Canadian Medical Research Councel and Saskatchewan Health for their continuing financial support.  相似文献   

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Summary Porphyrin biosynthesis from 4,5-dioxovaleric acid was studied in cell suspensions ofR. spheroides. The experiments show that 4,5-dioxovaleric acid is a far precursor of porphyrins through amino laevulinic acid formation in a transamination reaction involving also 1-alanine. It differs radically from the classical aminolaevulinic acid synthesis using glycine and succinyl CoA as substrates.Acknowledgments: The authors are indebted to Dr Rodolfo García for helpful discussions and criticisms. Special thanks are given to Dr Aldo Mitta and other members of the Comisión Nacional de la Energía Atómica for their continuous help and support and for using their facilities in order to synthetise DVA.  相似文献   

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