Aneuploidy as a consequence of senescence and ovariectomy in the golden hamster (Mesocricetus auratus)

The hypothesis of the preferred X-chromosome loss in elder human females was reevaluated in the golden hamster: early castration of females proved that the increase of aneuploid cells is correlated with the loss of the ovaries. But here, and in old females, aneuploidy consisted of random loss of excess of chromosomes, in no case an X-chromosome.     

Aneuploidy as a consequence of senescence and ovariectomy in the golden hamster (Mesocricetus auratus)

Summary The hypothesis of the preferred X-chromosome loss in elder human females was reevaluated in the golden hamster: early castration of females proved that the increase of aneuploid cells is correlated with the loss of the ovaries. But here, and in old females, aneuploidy consisted of random loss or excess of chromosomes, in no case an X-chromosome.     

Complete development ofAncylostoma ceylanicum (Looss, 1911) in golden hamsters,Mesocricetus auratus

Zusammenfassung Es gelang, den HakenwurmAncylostoma ceylanicum an den Goldhamster zu adaptieren, was zur Vereinfachung chemotherapeutischer Versuche bei der Bekämpfung dieses tierischen und menschlichen Parasiten im Laboratorium beitrug.     

The activation of membrane ATPase by ouabain in several tissues of the golden hamster (Mesocricetus auratus) in the absence of potassium

Summary The activity of the membrane ATPase of 5 organs of the golden hamster was increased by 10^–7–10^–3 moles/l ouabain in K⁺-free medium. In similar experiments on rats no increase was observed.     

Profound hypothermia in golden hamsters (Mesocricetus auratus) induced by serotonergic potentiating and noradrenergic inhibiting drugs

Profound hypothermia (6 degrees C) was induced in cold exposed golden hamsters (Mesocricetus auratus) by a combination of drugs that potentiate brain serotonergic activity (fluoxetine and pargyline) and inhibit noradrenergic activity (alpha-methyl-p-tyrosine). Individual drugs and combinations of 2 were ineffective.     

Profound hypothermia in golden hamsters (Mesocricetus auratus) induced by serotonergic potentiating and noradrenergic inhibiting drugs

Summary Profound hypothermia (6°C) was induced in cold exposed golden hamsters (Mesocricetus auratus) by a combination of drugs that potentiate brain serotonergic activity (fluoxetine and pargyline) and inhibit noradrenergic activity (alpha-methyl-p-tyrosine). Individual drugs and combinations of 2 were ineffective.Acknowledgements. We acknowledge the support of a research grant PCM74-05158 A01 to A.H.M. from the National Science Foundation (USA) and thank Lilly Research Laboratories, Indianapolis, Indiana, for the gift of fluoxetine (Lilly 110140).     

Oxidative activity during the sexual cycle of the central nervous system,adrenal glands and ovaries in the hamster (Mesocricetus auratus)

Summary The results indicate significant increases of the oxidative metabolism in the oestrus of the ovaries, hypothalamus and the posterior cortex, while in the amygdala this increase occurs in the phase of diestrus.     

Lithium suppresses hibernation in the Turkish hamster

Daily uptake of lithium salt (LiCl) in the drinking water at a rate of over 100 micrograms/g b.wt (or 2.4 mEq/kg) reduced or suppressed natural torpidity (hibernation) in the Turkish hamster (Mesocricetus brandti). The data indicate a direct influence of lithium on clock-related functions controlling the hibernation process rather than indirect effects by preventing gonadal regression and thereby also hibernation.     

Effects of ovariectomy on the oxidative metabolism of the central nervous system and adrenal glands in female hamster (Mesocricetus auratus)

Summary We have studied the influence of ovariectomy on the oxidative activity of hypophysis, hypothalamus, posterior cortex, septal area, amygdala and adrenal glands, in female hamsters, because their neuroendocrine behavior seems to differ from that of rats. Our results show a decreasing the O₂ uptake in the hypothalamus and adrenal glands and an increase in the rest of the structures.     

Effects of ovariectomy on the oxidative metabolism of the central nervous system and adrenal glands in female hamster (Mesocricetus auratus)

We have studied the influence of ovariectomy on the oxidative activity of hypophysis, hypothalamus, posterior cortex, septal area, amygdala and adrenal glands, in female hamsters, because their neuroendocrine behavior seems to differ from that of rats. Our results show a decreasing the O2 uptake in the hypothalamus and adrenal glands and an increase in the rest of the structures.     

Immunohistochemical localization fo galactocerebroside in kidney,liver, and lung of golden hamster

Summary Localization of galactocerebroside in kidney, liver, and lung of hamster was studied by the immunoperoxidase method using an affinity-purified specific antibody. Epithelial cells of the following anatomical sites were labelled with the antibody: distal tubuli, ascending limbs of Henle's loops, and collecting tubuli in kidney; periportal bile ducts and hepatic parenchyma in liver; bronchioli and alveoli in lung. The existence of galactocerebroside in these 3 organs was also confirmed by chemical analysis.This study was supported in part by grants from the Ministry of Education, Science and Culture of Japan, a Research Grant for Intractable Diseases from the Ministry of Health and Welfare of Japan, and a grant from the Mitsubishi Foundation.