亲水性液相色谱聚合物填料的合成及性能

在苯乙烯、二乙烯苯多孔聚合物微球表面键联中性一缩二乙二醇制成新型亲水性相色谱固定要，并对固定相的刚性、溶胀性、物质分离的选择性以及孔径对柱效的影响进行了评价，改性聚苯乙烯填料具有柱效高、刚性好、化学性能稳定的特点，适合于芳香胺、酚类化合物的分离。     

手性多孔戊基笼用于高效液相色谱拆分手性化合物

高效液相色谱法拆分手性化合物是目前较为常用的一种手性分离手段,色谱拆分的关键在于探索新型高效的色谱固定相.手性多孔有机笼是一类新型的纯有机多孔晶体材料.文章合成了一种具有单一手性结构的多孔戊基笼,并将其涂渍在硅胶表面,制备了涂渍型高效液相色谱手性固定相.以正己烷/异丙醇为流动相,研究了该手性固定相对手性化合物的手性识别性能.结果表明,该固定相对手性化合物具有较好的手性识别能力.     

十四烷基磷酸钍的合成及气相色谱性能研究

化学键合相色谱固定相是借助于非均相化学反应,将有机分子以共价键形式连接在色谱担体上,如硅胶键合相。它具有耐溶剂洗、热稳定性较好、表面改性灵活等特点,因而广泛应用于色谱分离分析中。但其表面极性点不能完全清除,降低了键合相填料的化学稳定性,致使产品性能重复性差,并影响分离效果。本文采用均相化学反应合成了一种     

纤维素-三(3,5-二甲基苯基氨基甲酸酯)液相色谱固定相高效拆分芳香类有机污染物

以纤维素和3,5-二甲基苯基异氰酸酯为原料合成了纤维素-三(3,5-二甲基苯基氨基甲酸酯),然后将其涂敷在经3-氨丙基-三乙氧基硅烷修饰的硅胶上,制备了纤维素-三(3,5-二甲基苯基氨基甲酸酯)液相色谱固定相.研究了该固定相对苯、萘、蒽、菲4种芳香类有机污染物的拆分性能,考查了流速和流动相的比例等主要因素对目标化合物分离的影响.结果表明:以纤维素-三(3,5-二甲基苯基氨基甲酸酯)为液相色谱固定相,正己烷/异丙醇(80∶20,v/v)为流动相,在0.4 mL/min的流速下,4种芳香烃类化合物能完全达到基线分离,且分离度分别为R_(S(苯萘))=2.19,R_(S(苯蒽))=7.58,R_(S(苯菲))=15.42.该方法稳定性好、简单易行,在去除和资源化循环利用环境中的芳香烃类有毒物质有潜在的应用前景.     

手性色谱固定相拆分手性药物坦索罗辛

采用天然手性中心多糖类手性反相色谱固定相填料,高氯酸钠水溶液和乙腈为流动相,在不同的流动相比例下拆分了手性药物坦索罗辛.研究了该化合物在不同条件下色谱参数变化的规律,包括保留时间、分离度、塔板数、半峰宽度、对称度等.得到了较好的拆分该手性化合物的色谱条件.     

咪唑嵌合半胱氨酸修饰固定相制备及色谱应用

利用“点击反应”合成了咪唑嵌合半胱氨酸硅胶固定相SIL-AVI-Cys,并通过热重、红外光谱以及元素分析对材料进行了表征.填充SIL-AVI-Cys色谱柱在分离胞核嘧啶、胞苷、肌苷、尿嘧啶和尿苷等5种亲水性化合物时表现为亲水作用模式,而在分离苯胺和苯酚类物质时则可表现出亲水/反相混合模式特征.通过考察流动相pH值、盐浓度对分析物保留的影响,进一步探讨了该固定相的分离机理.流动相pH值的改变可通过改变分析物的离子化影响其与固定相之间的作用力及其保留行为.流动相中盐浓度的增加,可减弱酸性分析物的保留,而对于碱性和中性分析物则无显著影响.此外,SIL-AVI-Cys色谱柱的分离性能采用酰胺及核酸碱基/核苷类物质进行了表征,并将其进一步应用于奶粉中三聚氰胺的表征和检测.     

Xtimate SEC色谱柱

月旭Xtimate SEC色谱柱是月旭材料科技（上海）有限公司自主研发的一款产品，填充的填料为高纯度、具有良好化学稳定性的硅胶微球。该填料采用独特的化学键合技术，其亲水性聚合物完全包覆在硅胶微球表面，使得水溶性聚合物、蛋白、生物酶、多肽等生物样品非特异性吸附大大降低，并且其填料键合亲水性二醇基基团确保了硅胶表面不与蛋白、生物酶、多肽等生物样品相互作用。该填料粒径目前有从1．8um以10um的各种规格，能够获得优异的体积排阻色谱性能。     

MMA-EDMA聚合物微球型和包覆硅胶型填料的制备与色谱性能

以Methyl methacrylate(MMA)和Ethylene dimethacrylate(EDMA)作为单体制备了多孔聚合物微球型(PG)和硅胶基质聚合物包覆型填料(PCSG).经电子显微镜、元素分析、尺寸排阻色谱和反相液相色谱对多孔聚合物微球粒径、硅胶基质聚合物包覆程度、交联剂添加对填料微孔构造的影响、非极性和极性化合物的色谱保留行为进行了评价和讨论.结果显示:PG和PCSG填料制备过程中形成了与C18填料不同的微孔结构;PG填料的大微孔体积Vb最大,PCSG填料小微孔体积Va最大.PG和PCSG填料的小微孔体积Va的不同导致填料表面具有相同的MMA高分子链却表现出不同的疏水性能;大微孔体积Vb的存在使填料对大体积芳香族化合物分离表现出了与C18填料不同的立体选择性.PG和PCSG填料因其表面残留有相同的MMA高分子链,使其对极性芳香族化合物表现出了相似的色谱保留行为.PCSG填料的柱效能介于C18和PG填料之间.     

奎宁功能化的混合模式有机-硅胶杂化整体柱的制备和应用

在氯丙基硅胶整体柱固定相表面,通过亲核反应衍生奎宁功能单体,制备新型混合模式有机-硅胶杂化整体柱.实验考察杂化整体柱的结构特征和电色谱性能,结果表明衍生奎宁后的杂化整体柱结构均匀,重现性良好,在酸性条件下产生较大的反向电渗流.整体柱通过对极性小分子、多环芳烃及有机酸类物质的分离,体现出明显的反相作用、π-π作用和阴离子交换作用.在混合模式作用下,成功分离了碱性的烟碱类化合物.     

氧化石墨烯功能化分离材料的制备及其应用

石墨烯骨架的大型p电子离域系统对包含芳香环的物种(如蛋白质)具有很强的亲和力,其表面上丰富的活性位点提供了通过功能修饰来调节对特定蛋白质的吸附趋势的机会。该文概述了当前对基于石墨烯/氧化石墨烯的材料的研究,及其在分离分析和相关领域方面的应用,以期为进一步探索提供依据。我们希望这篇综述将提高人们对G/GO及其衍生物等的性能的认识,并促进该领域研究的新应用的发展。     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

On the Thermodynamic Limit for Responses to Static Electromagnetic Fields

For molecular systems,the quantum-mechanical treatment of their responses to static electromagnetic fields usually employs a scalar-potential treatment of the electric field and a vector-potential treatment of the magnetic field.Although the potential for each field separately is associated with the choice of an(unphysical)origin,the precise choice of the origin for the electrostatic field has little consequences for the results.This is different for the     

An affordable accurate evaluation of the binding conformations predicted by molecular docking studies in bio-system

Franck-Condon factors bridge the gap between theoretical modeling and experimental observations for molecular electronic spectroscopy and electron transfer.Under the displaced harmonic oscillator approximation,multidimensional Franck-Condon factors are decomposed into a product of many one-dimensional(1D)Franck-Condon(FC)factors,and each 1D-FC factor is associated with one Huang-Rhys factor that determines the leading contribution of     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with