Metabolism of testosterone in organ culture of the Mullerian crest in the new Pleurodeles waltl Michah]

Radioactive testosterone is very quickly collected by the mullerian ducts, and then metabolized in androstanolone and androstanediols. According to these investigations, the mullerian duct shows an usual feature of the effectors of androgens. The possible r?le of the different metabolites is discussed.     

In vitro evaluation of cutaneous potentials in the triton, Pleurodeles waltlii Michah., by measuring transepithelial potentials]

Surface potentials previously measured in vivo have been approximately evaluated in vitro by means of an experimental device allowing a simultaneous record of transepithelial potential differences in 2 areas of the same skin piece cut out along the proximo-distal direction of the anterior limb of Pleurodeles waltlii. These potentials are thus explained by unequal transepithelial potential differences in the proximal and distal areas of the same skin sample.     

Action of testosterone and androstanolone on mullerian duct of Triton Pleurodeles waltl Michah. in organ culture]

Testosterone and androstanolone promote hyperplasia and differentiation of ciliated cells of the mullerian duct of immature newts, in organe culture. Cyproterone inhibits these effects. Association of testicular explants with mullerian ducts also reduces the androgen action.