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Summary The influence of phenobarbital and TCDD pretreatment on the formation and biliary excretion of TCDD-metabolites following single doses of3H-TCDD was investigated. Without pretreatment, 24.5% of the absorbed3H-TCDD dose was excreted in the bile within 110 h. Phenobarbital did not influence this rate, whereas a single dose of 10 g of unlabeled TCDD/kg b.wt nine days earlier resulted in a doubling of the amount of radioactive material eliminated in the bile (47.4%). 相似文献
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C. Franzini T. Cianci P. Lenzi J. P. Libert J. A. Horne P. L. Parmeggiani 《Cellular and molecular life sciences : CMLS》1986,42(6):604-606
Summary In young rabbits the slope of the temperature in the deep cervical region close to brown adipose tissue increased during desynchronized sleep at low ambient temperature. No increase occurred at neutral ambient temperature. In control rabbits (after disappearance of brown adipose tissue), the slope of deep cervical temperature did not increase during desynchronized sleep at low or neutral ambient temperatures.Preliminary data were reported at the Association des Physiologistes, Réunion de Poitiers, 20–23 June 1983.Acknowledgments. We wish to thank Giuseppe Mancinelli and Leonida Sabattini for technical assistance. This work was supported by a grant from the Consiglio Nazionale delle Ricerche, Rome. J.P.L. wishes to thank NATO for partial financial support during his stay at the Physiology Department in Bologna. 相似文献