共查询到20条相似文献,搜索用时 31 毫秒
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p63 in epithelial development 总被引:2,自引:0,他引:2
Candi E Cipollone R Rivetti di Val Cervo P Gonfloni S Melino G Knight R 《Cellular and molecular life sciences : CMLS》2008,65(20):3126-3133
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Diverse molecular functions of Hu proteins 总被引:1,自引:1,他引:0
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Reticulons (RTNs) are membrane-spanning proteins sharing a typical domain named reticulon homology domain (RHD). RTN genes
have been identified in all eukaryotic organisms examined so far, and the corresponding proteins have been found predominantly
associated to the endoplasmic reticulum membranes. In animal and yeast, in which knowledge of the protein family is more advanced,
RTNs are involved in numerous cellular processes such as apoptosis, cell division and intracellular trafficking. Up to now,
a little attention has been paid to their plant counterparts, i.e., RTNLBs. In this review, we summarize the data available for RTNLB proteins and, using the data obtained with animal and
yeast models, several functions for RTNLBs in plant cells are proposed and discussed.
Received 01 July 2008; received after revision 08 September 2008; accepted 30 September 2008 相似文献
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The continuing disappearance of “pure” Ca2+ buffers 总被引:1,自引:1,他引:0
B. Schwaller 《Cellular and molecular life sciences : CMLS》2009,66(2):275-300
Advances in the understanding of a class of Ca2+-binding proteins usually referred to as “Ca2+ buffers” are reported. Proteins historically embraced within this group include parvalbumins (α and β), calbindin-D9k, calbindin-D28k
and calretinin. Within the last few years a wealth of data has accumulated that allow a better understanding of the functions
of particular family members of the >240 identified EF-hand Ca2+-binding proteins encoded by the human genome. Studies often involving transgenic animal models have revealed that they exert
their specific functions within an intricate network consisting of many proteins and cellular mechanisms involved in Ca2+ signaling and Ca2+ homeostasis, and are thus an essential part of the Ca2+ homeostasome. Recent results indicate that calbindin-D28k, possibly also calretinin and oncomodulin, the mammalian β parvalbumin,
might have additional Ca2+ sensor functions, leaving parvalbumin and calbindin-D9k as the only “pure” Ca2+ buffers.
Received 10 September 2008; received after revision 15 October 2008; accepted 4 November 2008 相似文献
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Y. Sugano 《Cellular and molecular life sciences : CMLS》2009,66(8):1387-1403
Dye-decolorizing peroxidase (DyP) is produced by a basidiomycete (Thanatephorus cucumeris Dec 1) and is a member of a novel heme peroxidase family (DyP-type peroxidase family) that appears to be distinct from general
peroxidases. Thus far, 80 putative members of this family have been registered in the PeroxiBase database (http://peroxibase.isbsib.ch/)
and more than 400 homologous proteins have been detected via PSI-BLAST search. Although few studies have characterized the
function and structure of these proteins, they appear to be bifunctional enzymes with hydrolase or oxygenase, as well as typical
peroxidase activities. DyP-type peroxidase family suggests an ancient root compared with other general peroxidases because
of their widespread distribution in the living world. In this review, firstly, an outline of the characteristics of DyP from
T. cucumeris is presented and then interesting characteristics of the DyP-type peroxidase family are discussed.
Received 14 October 2008; received after revision 12 November 2008; accepted 17 November 2008 相似文献
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Metallomics and metalloproteomics 总被引:1,自引:0,他引:1
Metallomics and metalloproteomics are emerging fields addressing the role, uptake, transport and storage of trace metals essential
for protein functions. The methodologies utilized in metallomics and metalloproteomics to provide information on the identity,
quantity and function of metalloproteins are discussed. The most widely used approach is through inductively coupled plasma
mass spectrometry to identify the metal bound to a protein, and electrospray ionization mass spectrometry to elucidate the
structure, dynamics and function of a metal-protein complex. Other approaches include X-ray absorption and X-ray fluorescence
spectroscopies, and bioinformatics sequence analysis. X-ray absorption spectroscopy utilizing a synchrotron radiation source
is a powerful tool to provide a direct analysis of metal bound to proteins and proteomic metal distribution in biological
matrices. With the advent of genome sequencing, a large database of protein primary structures has been established, and specific
tools to identify metalloproteins in the genome sequences have been developed.
Received 8 April 2008; received after revision 12 May 2008; accepted 15 May 2008 相似文献
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A dynamic view of peptides and proteins in membranes 总被引:1,自引:0,他引:1
Bechinger B 《Cellular and molecular life sciences : CMLS》2008,65(19):3028-3039
Biological membranes are highly dynamic supramolecular arrangements of lipids and proteins, which fulfill key cellular functions.
Relatively few high-resolution membrane protein structures are known to date, although during recent years the structural
databases have expanded at an accelerated pace. In some instances the structures of reaction intermediates provide a stroboscopic
view on the conformational changes involved in protein function. Other biophysical approaches add dynamic aspects and allow
one to investigate the interactions with the lipid bilayers. Membrane-active peptides fulfill many important functions in
nature as they act as antimicrobials, channels, transporters or hormones, and their studies have much increased our understanding
of polypeptide-membrane interactions. Interestingly several proteins have been identified that interact with the membrane
as loose arrays of domains. Such conformations easily escape classical high-resolution structural analysis and the lessons
learned from peptides may therefore be instructive for our understanding of the functioning of such membrane proteins.
Received 11 March 2008; received after revision 2 May 2008; accepted 5 May 2008 相似文献
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The BAG (Bcl-2 associated athanogene) family is a multifunctional group of proteins that perform diverse functions ranging from apoptosis to tumorigenesis.
An evolutionarily conserved group, these proteins are distinguished by a common conserved region known as the BAG domain.
BAG genes have been found in yeasts, plants, and animals, and are believed to function as adapter proteins forming complexes
with signaling molecules and molecular chaperones. In humans, a role for BAG proteins has been suggested in carcinogenesis,
HIV infection, and Parkinson’s disease. These proteins are therefore potential therapeutic targets, and their expression in
cells may serve as a predictive tool for such diseases. In plants, the Arabidopsis thaliana genome contains seven homologs of the BAG family, including four with domain organization similar to animal BAGs. Three members
contain a calmodulin-binding domain possibly reflecting differences between plant and animal programmed cell death. This review
summarizes current understanding of BAG proteins in both animals and plants.
Received 21 November 2007; received after revision 17 December 2007; accepted 2 January 2008 相似文献
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Based on the classification of bacterial lipolytic enzymes, family I.3 lipase is a member of the large group of Gram-negative
bacterial true lipases. This lipase family is distinguished from other families not only by the amino acid sequence, but also
by the secretion mechanism. Lipases of family I.3 are secreted via the well-known type I secretion system. Like most of proteins
secreted via this system, family I.3 lipases are composed of two domains with distinct yet related functions. Recent years
have seen an increasing amount of research on this lipase family, in terms of isolation, secretion mechanism, as well as biochemical
and biophysical studies. This review describes our current knowledge on the structure-function relationships of family I.3
lipase, with an emphasis on its secretion mechanism.
Received 18 April 2006; received after revision 3 July 2006; accepted 24 August 2006 相似文献
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Galat A 《Cellular and molecular life sciences : CMLS》2008,65(21):3481-3493
Extracellular domains of some cellular receptors expressed in the organisms at different levels of development belong to three-fingered
protein (TFP) fold. The Homo sapiens genome encodes at least 45 genes containing from one to three TFP domains (TFPDs), namely diverse paralogues of the Ly6 gene,
CD59 and the receptors of activins, bone morphogenetic proteins, Mullerian inhibiting substance and transforming growth factor-β.
C4.4a and urokinase/plasminogen activatory receptor contain two and three TFPD repeats, respectively. These diverse proteins
have a low overall sequence similarity with each other and their hydrophobicity levels vary to a considerable degree. It is
suggested that sequence differentiation within the TFPD led to distinct groups of proteins whose attributes were optimized
to fit both the physicochemical properties specific to their functional microenvironment and selective targeting of their
highly diversified extracellular cofactors.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
Received 7 August 2008; accepted 29 August 2008 相似文献
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Engen JR Wales TE Hochrein JM Meyn MA Banu Ozkan S Bahar I Smithgall TE 《Cellular and molecular life sciences : CMLS》2008,65(19):3058-3073
Src-family kinases are modular signaling proteins involved in a diverse array of cellular processes. All members of the Src
family share the same domain organization, with modular SH3, SH2 and kinase domains followed by a C-terminal negative regulatory
tail. X-ray crystallographic analyses of several Src family members have revealed critical roles for the SH3 and SH2 domains
in the down-regulation of the kinase domain. This review focuses on biological, biophysical, and computational studies that
reveal conformationally distinct active states within this unique kinase family.
Received 10 March 2008; received after revision 17 May 2008; accepted 21 May 2008 相似文献
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Welcome the Family of FANCJ-like Helicases to the Block of Genome Stability Maintenance Proteins 总被引:1,自引:0,他引:1
Y. Wu A. N. Suhasini R. M. Brosh Jr. 《Cellular and molecular life sciences : CMLS》2009,66(7):1209-1222
The FANCJ family of DNA helicases is emerging as an important group of proteins for the prevention of human disease, cancer,
and chromosomal instability. FANCJ was identified by its association with breast cancer, and is implicated in Fanconi Anemia.
Proteins with sequence similarity to FANCJ are important for maintenance of genomic stability. Mutations in genes encoding
proteins related to FANCJ, designated ChlR1 in human and Chl1p in yeast, result in sister chromatid cohesion defects. Nematodes
mutated in dog-1 show germline as well as somatic deletions in genes containing guanine-rich DNA. Rtel knockout mice are embryonic lethal, and embryonic stem cells show telomere loss and chromosomal instability. FANCJ also shares
sequence similarity with human XPD and yeast RAD3 helicases required for nucleotide excision repair. The recently solved structure
of XPD has provided new insight to the helicase core and accessory domains of sequence related Superfamily 2 helicases. The
functions and roles of members of the FANCJ-like helicase family will be discussed.
Received 17 September 2008; received after revision 24 October 2008; accepted 28 October 2008 相似文献
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Multi-layered regulation of intestinal antimicrobial defense 总被引:1,自引:0,他引:1
Mukherjee S Vaishnava S Hooper LV 《Cellular and molecular life sciences : CMLS》2008,65(19):3019-3027