The adenohypophysial hormone content of the rat pars tuberalis

Summary The pars tuberalis of the hypophysis was shown to contain LH, which increases after castration, TSH and a very low amount of PRL. FSH was found after castration.This investigation was supported by the Fundación Instituto de Neurobiología and CONICET. The authors want to thank Dr A.F. Parlow for supplying the NIAMDD radioimmunoassay kits.     

Untersuchungen zur biologischen Wirksamkeit eines A-homo-Testosteronacetates

Summary The biological efficiency of a high purified A-homo-testosterone-acetate was tested on male mice. We found no inhibition of the gonadotropic partial-function of the anterior pituitary by the substance; and furthermore no substitution of testosterone deficit after castration was possible.     

Effects of submandibularectomy and castration on thymus and spleen weights in male mice

Cellular and Molecular Life Sciences - Submandibular-sublingualectomy of male mice did not result in thymic hyperplasia or potentiate the thymic hyperplasia which occurs after castration....     

Critical comment on the "trophic" influence of the effector organ on the sympathetic nerves of the male sex accessories of the guinea-pig.

There is no absolute parallelism between organ noradrenaline content and organ weight in the male sex accessories during normal development or following regression after castration.     

Critical comment on the ‘Trophic’ influence of the effector organ on the sympathetic nerves of the male sex accessories of the guinea-pig

Summary There is no absolute parallelism between organ noradrenaline content and organ weight in the male sex accessories during normal development or following regression after castration.     

Action de la castration partielle ou totale sur la croissance et le fonctionnement de l'appareil génital chez le planorbeBiomphalaria glabrata (gastéropode pulmoné)

Summary Total castration increases the weight, delays oviposition and reduces the functioning of the genital organs but partial gonadectomy has no effect. After partial castration, the ovotestis does not regenerate. Partial or total castration has no effect on the wet and dry weight of the genital tracts.     

Persistence of infradian body weight cycles in castrated dormice (Glis glis)

Summary Male dormice were castrated at 2 phases of their infradian body weight cycles. No consistent changes were found in cycle period, amplitude, or absolute weights of the dormice following castration. Unlike other mammals, body weights of dormice appear unaffected by castration. Although both body weight and reproductive condition vary on an infradian basis, the changes in body weight appear to be programmed independently from changes in gonadal function.Acknowledgments. I would like to thank R. Melnyk, N. Mrosovsky, and J. D. Hallonquist for much helpful criticism and K. Lang and J. Kenyon for invaluable technical help. Research support was provided by a National Sciences and Engineering Research Council of Canada grant to N. Mrosovsky.     

Effects of CA on the epididymis of intact,castrated and TP-treated langurs (Presbytis entellus entellus Dufresne)

Summary Cyproterone acetate (CA) treatment of intact langurs resulted in the disappearance of spermatozoa and regression of epididymal lumen, which can be compared with castration. The antiandrogenic nature of CA was confirmed in castrates treated simultaneously with testosterone propionate.     

Pineal function cannot prevent the occurrence of castration cells in male rats

The relationship between the pineal gland and the pituitary gland was investigated in male rats. The results indicate that the hypothalamo-adenohypophysial-gonadal axis is affected by the pineal gland, but the appearance of castration cells following gonad ablation may be only slightly modified by alterations in pineal gland function.     

Pineal function cannot prevent the occurrence of castration cells in male rats

Summary The relationship between the pineal gland and the pituitary gland was investigated in male rats. The results indicate that the hypothalamo-adenohypophysial-gonadal axis is affected by the pineal gland, but the appearance of castration cells following gonal ablation may be only slightly modified by alterations in pineal gland function.     

Histochemistry of the lumenal cell surfaces of the mucosa of the oviducts and the uterus of the rat. Changes in prepuberty, estrous cycle, castration, hormone replacement and pseudopregnancy.

The lumenal surface coat of the rat oviducts and uterine horns have been histochemically characterized at prepuberty, estrous cycle, castration, hormone replacement and pseudopregnancy. Under the EM, the coat was made up of filamentous and globular structures. Histochemical variations suggested that coat components are under endocrine control.     

Autoradiographische Studien über die DNS-Synthese im Hypophysenvorderlappen der Ratte

Summary By autoradiographic studies with H³-thymidine it is demonstrated that the percentage of labelled nuclei is very low in the anterior pituitary of normal untreated rats and of rats 14 days after thyreoidectomy. Following castration, however, a marked increase of DNA-synthesizing cells occurs as well as an increase of mitotic figures.

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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft und das Bundesministerium für Wissenschaftliche Forschung.     

Aneuploidy as a consequence of senescence and ovariectomy in the golden hamster (Mesocricetus auratus)

The hypothesis of the preferred X-chromosome loss in elder human females was reevaluated in the golden hamster: early castration of females proved that the increase of aneuploid cells is correlated with the loss of the ovaries. But here, and in old females, aneuploidy consisted of random loss of excess of chromosomes, in no case an X-chromosome.     

Aneuploidy as a consequence of senescence and ovariectomy in the golden hamster (Mesocricetus auratus)

Summary The hypothesis of the preferred X-chromosome loss in elder human females was reevaluated in the golden hamster: early castration of females proved that the increase of aneuploid cells is correlated with the loss of the ovaries. But here, and in old females, aneuploidy consisted of random loss or excess of chromosomes, in no case an X-chromosome.     

Effect of testosterone on the kinetics of the development of suppressor cells in adjuvant arthritis

The induction of unresponsiveness to mycobacterial adjuvant took a longer time in male DA rats than in female rats. A shift in the induction time of unresponsiveness in males toward the female type was brought about by castration, but could be reverted to the male type by the application of testosterone. The transfer study revealed that cells capable of preventing arthritis required a longer incubation time for their development in males than in females. This suggests that testosterone inhibits the development of suppressor cells in adjuvant arthritis.     

Effect of testosterone on the kinetics of the development of suppressor cells in adjuvant arthritis

Summary The induction of unresponsiveness to mycobacterial adjuvant took a longer time in male DA rats than in female rats. A shift in the induction time of unresponsiveness in males toward the female type was brought about by castration, but could be reverted to the male type by the application of testosterone. The transfer study revealed that cells capable of preventing arthritis required a longer incubation time for their development in males than in females. This suggests that testosterone inhibits the development of suppressor cells in adjuvant arthritis.Acknowledgments. We are grateful to The Naito Foundation Research Grant for 1983.     

Interactions between α-MSH and sex steroids on the preputial glands of female rats

Résumé L'-MSH stimule la croissance des glandes préputiales de la rate intacte, cet effet est moins marqué après l'ablation des ovaires et s'atténue encore après castration et surrénalectomie ou castration et hypophysectomie. Chez l'animal castré, en doses liminaires, la progestérone accroÎt considérablement la stimulation produite par l'-MSH tandis que la testostérone exerce un effet comparable mais moins accentué. Le synergisme de la progestérone et de l'-MSH est encore observé, mais légèrement réduit, chez l'animal castré et surrénalectomisé ou castré et hypophysectomisé.     

Die Serumphosphatasen der Ratte in verschiedenen Lebensaltern

Summary The serum alkaline and acid phosphatases were examined in male rats between the ages of 20 and 300 days, using the method ofHuggins andTalalay ⁴. The activities of acid and alkaline phosphatases increase significantly to the age of 45 days, followed by a highly significant decrease up to 120th day for alkaline and to 75th day for acid phosphatase. After castration, highly significant increases in the acid, but no changes in the alkaline serum phosphatase were observed.     

Sur le mécanisme de la régression du canal de Müller droit chez l'embryon de Poulet femelle

Summary In the in vitro experiments described above neither the hormone of the left ovary nor that secreted by the rudimentary right gonad brought about the regression of the right Müllerian duct of the female chick embryo. In castration experiments, this naturally occurring phenomenon had been found to depend either on the right gonad (Huijbers ⁴) or on both the right and left gonads (Wolff ^1–3).     

Changes in total and polymerized tubulin of the medial basal hypothalamus and adenohypophysis of castrated or hormone-injected rats

Summary Treatment of orchidectomized rats with LH, FSH or prolactin decreased the tubulin content of the medial basal hypothalamus (MBH), whereas FSH or prolactin augmented it in the adenohypophysis (AH). After castration, negative correlations existed between serum LH and total or polymerized MBH tubulin, whereas in the AH positive correlations were found. After estradiol-progesterone treatment of spayed rats a significant correlation was found between serum LH and the percentage of AH tubulin in the polymerized form.Deceased November 24, 1979This study was supported in part by grants from the Consejo Nacional de Investigaciones Científicas y Técnicas (CON-ICET), Argentina (grant n^o 6638) and a John Simon Guggenheim Memorial Foundation Fellowship to DPC.