沃丽汀片治疗中心性浆液性脉络膜视网膜病变的临床观察

目的通过中心性浆液性视网膜脉络膜病变(central serous chorolretin Opathy, CSC)患者口服沃立汀片治疗前后的光学相干断层扫描(optical coherence tomography,OCT)图像的测量分析,评价沃立汀治疗CSC的疗效.方法选择门诊随访资料完整的CSC患者20例23眼,给予沃立汀片口服,每日三次,每次1. 5mg,在药物治疗前以及治疗后2周、4周、8周,16周进行OCT扫描并做图像测量分析.结果治疗后16周复查治愈20眼(87.0%),显效23眼(100%),无效0眼(0%).结论沃立汀片药效稳定,持久,使用安全,方便,应用治疗中心性浆液性脉络膜视网膜病变疗效肯定,确切.OCT能显示CSC的直观图像并能精确测量,对随访病情变化有客观指导意义.     

针刺联合明目地黄胶囊治疗中心性浆液性脉络膜视网膜病变的临床观察

目的 观察针刺联合明目地黄胶囊治疗中心性浆液性脉络膜视网膜病变(centralserouoschorioretinopathy,CSC)的临床疗效.方法 选择CSC患者64例(68眼),随机分为对照组和治疗组.对照组采用维生索C、肌苷、三磷酸腺苷等常规治疗,治疗组在对照组基础上加用明目地黄胶囊和针刺疗法,4周后观察疗效...     

一种基于改进U形网络的 眼底图像视网膜新生血管检测方法

糖尿病性视网膜病变(简称糖网病)是主要的致盲眼疾病之一,视网膜新生血管的出现是糖网病恶化的重要标志.为了更准确地检测出视网膜新生血管,本文提出了一种基于彩色眼底图的视网膜新生血管检测方法.首先通过一种改进的U形卷积神经网络对血管进行分割;然后利用滑动窗口提取特定区域内血管的形态特征,通过支持向量机将窗口内的血管分为普通血管和新生血管.使用来自MESSIDOR数据集和Kaggle数据集的含有视网膜新生血管的彩色眼底图对实验进行训练和测试,结果表明该方法对视网膜新生血管检测的准确率为95.96％;该方法在糖网病计算机辅助诊断方面有潜在的应用前景.     

中药治疗糖尿病性视网膜病变的实验研究

糖尿病视网膜病(Diabetic Retinopathy,DR)是糖尿病眼部最严重的并发症,是50岁以上人群的重要致盲性眼病之一,已成为防盲的重要课题[1].现代中医眼科将DR命名为"消渴目病".但其治疗效果缺乏客观的评价.本研究通过动物模型研究,评价生脉散合玉女煎、六味地黄汤和参苓白术散治疗STZ-糖尿病视网膜病大鼠的效果.     

PARP介导氧化应激与糖尿病视网膜病变的研究进展

糖尿病视网膜病变(DR)因其发病率高、病情严重而倍受人们关注,氧化应激能通过各种途径损伤糖尿病的视网膜.聚腺苷二磷酸核糖聚合酶(PARP)是目前国外研究较热的一种酶,并有较多实验证据表明PARP能介导氧化应激并参与糖尿病视网膜疾病的发生.该文就PARP在DR发病中的作用做一综述.     

基于不同材料模型的混凝土SHPB试验数值模拟

为了分析不同材料模型对混凝土分离式霍普金森压杆(SHPB)试验数值模拟结果的影响,在LS-DYNA软件中分别运用KC,HJC,CSC三种材料模型对混凝土的SHPB试验进行模拟.利用脉冲整形器对入射波进行整形以减小弥散效应,实现恒应变率加载,并从SHPB试验的基本假定出发验证了有限元模型的准确性.通过数值模拟得到了不同撞击速度下基于3种材料模型的混凝土破坏过程及其应力-应变曲线.结果表明:KC,HJC,CSC三种模型基本上能够反映混凝土的动态力学特性,且KC模型和CSC模型的失效模式为核心塌陷,而HJC模型则表现出留核现象;在相同的平均应变率下,HJC模型和KC模型的动力放大系数大于CSC模型;随着平均应变率的增加,峰值应变增大,CSC模型和HJC模型的割线刚度减小,而KC模型的割线刚度变化不明显.     

Improving the sintering performance of blends containing Canadian specularite concentrate by modifying the binding medium

Canadian specularite concentrate (CSC) possesses high total iron grade and low impurity content. However, due to the poor granulating performance and weak reactivity of CSC at high temperature, the proportion of CSC used in sintering blends is restricted. In this research, the effects of fine limonite, slake lime, and bentonite particles on the granulation performance of blends containing a high ratio of CSC were studied through granulation test. Based on the test results, the effects of modification of the binding medium on the sintering performance of blends containing a high ratio of CSC were revealed by the sintering pot test. Both the granulation property and sintering performance of blends with a high proportion of CSC were improved by modifying the binding medium.     

糖尿病性视网膜病变检查方法的进展

糖尿病引起的眼部并发症较多,其中以眼底视网膜病变最为常见.对糖尿病视网膜病变传统的检查方法和新进展的检查方法做一综述,其中重点介绍了新进展的检查方法对糖尿病视网膜病变(diabetic retinopathy,DR)眼底表现的观察及对DR的早期诊断的意义和重要性.     

玻璃体切割联合视网膜光凝治疗增殖性糖尿病视网膜病变

目的:探讨玻璃体切割联合眼内视网膜光凝治疗增殖性糖尿病视网膜病(PDR)病变疗效。方法:对30例30眼PDR患者进行玻璃体切割联合眼内视网膜光凝,11眼行巩膜环扎术,其中8眼行硅油填充,15眼行白内障摘除。结果:术后三月随访26眼视力都有明显好转,4眼由于视网膜下出血及增殖膜,视力提高不明显。结论:玻璃体切割联合眼内视网膜光凝治疗PDR有明显疗效,同时也是目前治疗PDR最有效的手段。     

色素上皮衍生因子在视网膜疾病中的应用研究进展

色素上皮衍生因子(pigment epithelium-derived factor, PEDF)是一种多效的神经营养因子和新生血管抑制因子,其在视网膜的生长发育及许多疾病病理过程中起着神经分化、神经营养、神经保护和抑制新生血管形成等作用,并可抗肿瘤和调控一些炎症反应.本文主要是综述目前对PEDF的生物学特点、作用及其在视网膜疾病中的应用研究状况,并推测其可能作用机制,展望其在视网膜疾病的临床治疗中的应用前景.     

A novel strategy for cancer treatment: Targeting cancer stem cells

Cancer stem cell/tumor-initiating cell （CSC/TIC） is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recurrence and tumor resistance to radiotherapy and chemotherapy. At present, small molecule inhibitors and fusion proteins are widely used in the CSC-targeting strategy. Gene-virotherapy, which uses oncolytic adenovirus as a vector to mediate the expression of therapeutic gene, shows a significant superiority to other regimens of cancer treatment and has a good efficacy in the treatment of solid tumors. Thus, it is a promising choice to apply gene-virotherapy into the CSC-targeting treatment. Based on the molecular mechanism underlying CSC self-renewal, a series of effective strategies for targeting CSC have been established. This review will summarize the recent research progresses on CSC-targeting treatment.     

Optimal carrier-smoothed-code algorithm for dual-frequency GPS data

Carrier-smoothed-code (CSC) algorithm is an effective pseudorange multipath mitigation technique, which can alleviate the computational burden and reduce the communication bandwidth needed for the transmission of GPS observations. This paper presents an improved Hatch filter and address the optimal CSC algorithm for dual-frequency GPS data based on the optimal parameter estimation theory. The smoothed observations have the same information content as that of the raw dual-frequency GPS data from which they are derived. Consequently, the optimal CSC algorithm is equivalent to the uncombined algorithm. Theoretical analyses show that the data precision of the optimal CSC algorithm is better than that of Hatch filter and its improved version.     

Optimal carrier-smoothed-code algorithm for dual-frequency GPS data

Carrier-smoothed-code （CSC） algorithm is an effective pseudorange multipath mitigation technique, which can alleviate the compu- tational burden and reduce the communication bandwidth needed for the transmission of GPS observations. This paper presents an improved Hatch filter and addresses the optimal CSC algorithm for dual-frequency GPS data based on the optimal parameter estimation theory. The smoothed observations have the same information content as that of the raw dual-frequency GPS data from which these are derived. Consequently, the optimal CSC algorithm is equivalent to the uncombined algorithm. Theoretical analyses show that the data orecision of the optimal CSC algorithm is better than that of Hatch filter and its imoroved version.     

中心性浆液性脉络膜视网膜病变病因及发病机制的研究进展

中心性浆液性脉络膜视网膜病变是由于视网膜色素上皮层（RPE）屏障功能障碍，脉络膜渗漏液进入视网膜神经上皮层下积存，致使神经上皮发生盘状脱离为特征的一种眼底疾病，其病因和发病机制尚不完全清楚，本文对近年来的研究进展做一综述．     

Comparison of CSC method and the B-net method for deducing smoothness condition

The first author of this paper established an approach to study the multivariate spline over arbitrary partition, and presented the so-called conformality method of smoothing cofactor (the CSC method). Farin introduced the B-net method which is suitable for studying the multivariate spline over simplex partitions. This paper indicates that the smoothness conditions obtained in terms of the B-net method can be derived by the CSC method for the spline spaces over simplex partitions, and the CSC method is more capable in some sense than the B-net method in studying the multivariate spline.     

形变热处理对CuAlNiMnTi组织和性能的影响

借助金相显微镜、DSC、X射线衍射和透射电镜等实验手段,研究了CuAlNiMnTi合金经高温形变热处理后对组织与性能的影响.试验结果表明,随合金变形量的增加晶粒尺寸变小,相变点M_s下降;适当形变热处理可以提高记忆性能,这是形成择优取向排列的马氏体作用的结果.     

CSC浆液性能特征及理论分析

本文在室内试验基础上,全面分析研究了CSC浆液主要性能特征及其影响因素.在理论研究中,着重分析了新型材料的粘塑性特征。研究结果表明,CSC浆液具备良好的性能特征,塑性强度增长规律与注浆——堵水过程相适应。