The European Brain Research Program 1989–1990 of the European Science Foundation (ESF)

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The European Brain Research Program 1989–1990 of the European Science Foundation (ESF)     

European Science Foundation: Report on the Scientific Networks 1985–1990 Excerpts from the ESF Communications

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European Science Foundation: Report on the Scientific Networks 1985–1990Excerpts from the ESF Communications     

United Kingdom: Extracts from the annual report for 1987–88 of the Science and Engineering Research Council

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United Kingdom: Extracts from the annual report for 1987–88 of the Science and Engineering Research Council     

United Kingdom: The Science and Engineering Research Council (SERC): A Report on Research in the United Kingdom,France and Germany (W)

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United Kingdom: The Science and Engineering Research Council (SERC): A Report on Research in the United Kingdom, France and Germany (W)     

European science foundation brain research programme 1990–1991

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European science foundation brain research programme 1990–1991     

European Molecular Biology Laboratory: Excerpts from the Annual Report for 1988

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European Molecular Biology Laboratory: Excerpts from the Annual Report for 1988     

European Molecular Biology Laboratory [EMBL]: Excerpts from the annual report 1989

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European Molecular Biology Laboratory [EMBL]: Excerpts from the annual report 1989     

United Kingdom: The Corporate Strategy for 1989 of the Medical Research Council (MRC)

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United Kingdom: The Corporate Strategy for 1989 of the Medical Research Council (MRC)     

The German Federal Republic: Annual report for 1990 of the Deutsche Forschungsgemeinschaft (DFG; German Research Association)

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The German Federal Republic: Annual report for 1990 of the Deutsche Forschungsgemeinschaft (DFG; German Research Association)     

United Kingdom: Report on the research programme on AIDS supported by the Medical Research Council [MRC]

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United Kingdom: Report on the research programme on AIDS supported by the Medical Research Council [MRC]     

Portugal: Recent Information from the Department of International Relations of the Instituto Nacional de Investigação Cientifica,Lisboa (INIC)

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Portugal: Recent Information from the Department of International Relations of the Instituto Nacional de Investigação Cientifica, Lisboa (INIC)     

The Second VDI-International Conference on Effects of Atmospheric Precipitations on Soils: Uptake,Assessment and Regulation (Lindau,Germany, 15–17 May 1990)

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The Second VDI-International Conference on Effects of Atmospheric Precipitations on Soils: Uptake, Assessment and Regulation (Lindau, Germany, 15–17 May 1990)     

Spierule cells inDrosophila species

Summary Spherule cells are restricted to the larval stage and make up 5–16% of cells in the hemolymph. Their morphology varies between species, mainly due to the shape of their inclusions which may be oval (spheroidocytes), polyhedral (crystalloid cells), or clearly crystalline (crystal cells). These inclusions are very rich in tyrosine. They liquefy rapidly in vitro, whereby the cells become hyaline (coagulocytes).Acknowledgments. We thank Mr B. Barandun for excellent technical assistance. This investigation was supported by the Swiss National Science Foundation, grant No. 3.792.076.     

Paradoxical effect of 1-β-D-arabinofuranosyl cytosine triphosphate on bleomycin-induced unscheduled DNA synthesis in permeable sarcoma cells

Summary 1--D-Arabinofuranosyl cytosine-5-triphosphate (araCTP), an inhibitor of DNA synthesis, paradoxically enhanced unscheduled DNA synthesis (USD) induced by bleomycin in permeable mouse sarcoma cells. A greater enhancing effect of araCTP on bleomycin-induced USD was observed with lower concentrations of dCTP in the assay mixture. USD measured without bleomycin in nuclei isolated from mouse sarcoma cells was not enhanced, but inhibited by araCTP.Acknowledgments. The authors wish to thank Nippon Kayaku Co. (Tokyo, Japan) for providing copper-free bleomycin A₂. This research was supported in part by a grant from the Japan Ministry of Education, Science and Culture.     

Termite soldier chemotaxonomy. A new diterpene from the Malaysian nasute termiteBulbitermes singaporensis

Summary The defense secretion of the nasute termiteBulbitermes singaporensis consists of 1 new and 2 known tetracyclic diterpenes, spectrometrically identified as 14-acetoxy-6,8-kempadien-3-one, 3, 14- and 3, 14-diacetoxy-6,8-kempadiene. The presence of these compounds supports the kinship of the oriental constricted-head genera withNasutitermes species in the Philippines and in East Africa.For 2 earlier papers in this series, see G. D. Prestwich, Sociobiol.4, 127 (1979); and G. D. Prestwich, Biochem. Syst. Ecol.7, 211 (1979).Financial support by the National Science Fondation (DEB-7823257) to G. D. Prestwich and by the University of Malaya to S. H. Goh is gratefully acknowledged. Address correspondence to G. D. P.     

Differential sensitivity to ethidium bromide of replicative DNA synthesis and bleomycin-induced unscheduled DNA synthesis in permeable mouse sarcoma cells1

Summary Replicative DNA synthesis in permeable mouse sarcoma cells was more sensitive to ethidium bromide (EtBr) than bleomycin-induced unscheduled DNA synthesis (UDS). A similar difference in sensitivity to EtBr was observed between DNA polymerases and . The difference in sensitivity to EtBr of replicative DNA synthesis and UDS in the present system seems to reflect mainly the sensitivity difference between DNA polymerases and .Acknowledgments. The authors wish to thank Nippon Kayaku Co. (Tokyo, Japan) for providing copper-free bleomycin A₂. This research was supported in part by a grant from the Japan Ministry of Education, Science and Culture.     

Vierdimensionale Geometrie und ihre praktische Anwendung zur Erklärung kosmologischer Probleme

Summary The expanding universe is considered to be a hypersphere immersed in a four dimensional space. An attempt is made to explain the rigid rotation of spiral and barred nebulae, not well understood on the basis of classical physics, by assuming that the geometrical solid nebula is a section of the universe through a four dimensional hypersolid of helicoidal curvature. Further applications of the extrapolation method to cosmology are suggested.

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Vorgetragen auf der Tagung der Sektion D (Astronomie) der American Association for the Advancement of Science, Atlanta, Georgia.     

The lateral transport of indoleacetic acid-C14 in geotropism

Zusammenfassung Die Hypothese, dass eine geotropische Reizung von Hafer-Koleoptilen eine Querverschiebung des Wuchsstoffes zur Folge hat, ist mit radioaktiver-Indolylessigsäure (Indol-CH₂C¹⁴OOH) bestätigt worden. Das Verhältnis der aus der oberen und der unteren Flanke von Koleoptil-Zylindern mit Agarblöckchen abgefangenen Indolylessigsäure wurde gleich 40:60 gefunden.Die Ursache dafür, dass dieser Effekt in längshalbierten Koleoptilen nicht festgestellt worden ist, liegt im grossen Anteil nicht transportierten Auxins in den Koleoptilen.

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This work was supported by a National Science Foundation predoctoral fellowship toBarbara Gillespie and by a grant from the National Science Foundation, No. G-9084, to ProfessorK. V. Thimann.     

Intracellular free calcium as a pathogen in cell damage initiated by the immune system

Summary It is proposed that the earliest intracellular event induced by the action of complement is an increase in cytosolic free calcium, which can occur in the absence of lysis. This increase causes morphological and chemical changes in the cell and also results in modified responses to physiological stimuli.In this article the term free calcium is used to mean ionised calcium, i.e. Ca²⁺, not bound to ligands.Acknowledgments. We are grateful to members of the Welsh National School of Medicine, University of Cambridge, School of Clinical Medicine, and the Marine Biological Association Laboratory, Plymouth, for valuable advice and discussions. In particular we thank our colleagues Dr M.B. Hallett, Dr P.J. Richardson and Mr R.A. Daw. We thank the Science and Medical Research Councils, the British Diabetic Association and the Arthritis and Rheumatism Council for supporting our experimental work.     

Increased liver calcium after calcium or milk gavage in rats

Summary For 1 or 2 h following a gavage of milk or 300 mM CaCl₂ (2 ml/100 g b.wt), rats had an increased liver calcium content when compared to rats receiving a deionized water gavage.Supported in part by a grant from the National Science Foundation (PCM 75-23603). We are grateful to Mr John O'Brien for his technical assistance.