共查询到20条相似文献,搜索用时 15 毫秒
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Structure of the pro alpha 2 (I) collagen gene 总被引:29,自引:0,他引:29
Fifty-four kilobase pairs (kbp) of cloned chicken DNA containing the entire 38-kbp pro alpha 2 (I) collagen gene have been isolated and characterized. DNA sequence analysis of a select 4 kbp of the gene has precisely described 14 exons which comprise one-third of the sequences encoding the triple-helical domain of the collagen protein. These exons range in size from 45 to 108 base pairs (bp), are all multiples of the 9 bp that code for the repeating triplet, Gly-X-Y, and have an average size of 70 bp. About 50 introns interrupt this gene. Nevertheless, introns do not separate the coding sequences for the ends of the central triple-helical structural domain and the ends of the propeptide domains. 相似文献
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类人胶原蛋白生物相容性实验研究 总被引:16,自引:6,他引:16
目的 为扩大类人胶原蛋白的应用,评定和比较猪胶原蛋白、类人胶原蛋白和明胶在动物体内的生物相容性。方法分别用胶原材料和明胶进行以下生物学测试:急性毒性试验、溶血试验、热原试验、皮肤刺激试验。根据标准对试验数据进行分析和评估。结果类人胶原蛋白的急性毒性试验、溶血试验、热原试验、皮肤刺激试验均为阴性。结论材料生物学测试结果显示类人胶原蛋白较其他两种材料的生物相容性更高,是理想的医用生物材料。 相似文献
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Electrical properties of wet collagen 总被引:10,自引:0,他引:10
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