A new antibacterial agent produced byStreptomyces sp. Ac6569

Zusammenfassung Ein neues, gegen Bakterien und Pilze wirsames Antibiotikum wurde aus demStreptomyces sp. Ac₆569 in der Form eines amorphen Hydrochlorids isoliert. Die Substanz ist wasserlöslich, aber fast unlöslich in organischen Lösungsmitteln, Schmp. 216–218° (Zersetzung); sie gehört zur Streptothricin-Gruppe der Antibiotika.     

Thermozymocidin new antifungal antibiotic from a thermophilic eumycete

Riassunto È stato isolato un nuovo antibiotico, denominato termozimocidina, attivo contro lieviti e funghi filamentosi, prodotto in coltura sommersa da un eumicete termofilo. Vengono presentate le principali propietà chimiche, fisiche e biologiche che ne permettono la sua caratterizzazione.     

Interconversion of T-2636 antibiotics produced byStreptomyces rochei var.volubilis

Zusammenfassung Mit angereicherten Enzympräparaten vonStreptomyces rochei var.volbulis sowie einigen Pilzen Hessen sich die Antibiotica T-2636 A (I) und D (III) zu C (II) beziehungsweise F (IV) reversibel desacetylieren. Die Antibiotica (III) und (IV) wurden auch mit dem EnzymS. rochei var.volubilis dehydriert.     

A new actinomycin-like antibiotic produced by a mutant strain ofStreptomyces indicus

Zusammenfassung Aus einer Mutante vonStreptomyces indicus Chakrabarty sp. nov. wurde das neue Antibiotikum MT-10 (orange-gelbe Kristalle) isoliert. Die antibakterielle und antifungische Aktivität wurde untersucht und festgestellt, dass MT-10 mit Actinomycin D verwandt ist.     

A new furanoterpene from aSpongia sp.

Summary A new C21 furanoterpene, oxygenated at C(8), has been isolated from aSpongia sp.; its structure has been established by chemical and spectroscopic studies. The stereochemistry of tetradehydrofurospongin-1 is discussed.A specimen of the sponge has been deposited at the Western Australian Museum (Catalogue No. WAM 429-81). We thank Miss J. Fromont for taxonomic information.A specimen of the sponge has been deposited at the Western Australian Museum (Catalogue No. WAM 483-82). We thank Professor Bergquist for taxonomic information.     

Peptide antibiotic biosynthesis: A new approach

Zusammenfassung Eine verallgemeinernde biosynthetische Theorie über die Entstehung vond-Aminosäuren in Peptid-Antibiotika wird dargestellt und zur Bildung von makrozyklischen Strukturen aus kleineren Ring-systemen in Beziehung gesetzt.     

A new 9,11-secosterol,stellettasterol from a marine spongeStelletta sp

A new 9,11-secosteroid, stellettasterol (1) was isolated from a Japanese marine sponge,Stelletta sp.; its structure was determined by spectroscopic analysis. All NMR signals of1 were unambiguously assigned by application of various 2D NMR techniques. Stellettasterol exhibited antifungal activity againstMortieralla ramannianus.Part 62 of the Bioactive Marine Metabolites series. Part 61: Fusetani, N., Takahashi, M., and Matsunaga, S., Tetrahedron, in press.     

2,3-Dihydrolinderazulene,a new bioactive azulene pigment from the gorgonianAcalycigorgia sp.

Summary A new azulene pigment, 2,3-dihydrolinderazulene, has been isolated along with guaiazulene and linderazulene as bioactive metabolites from the gorgonianAcalycigorgia sp.     

Toxic substances produced byFusarium. III. Production and screening of phytotoxic substances ofF. oxysporum f. sp.carthami responsible for the wilt disease of safflowerCarthamus tinctorius Linn.

Summary Fusarium oxysporum f. sp.carthami, a causative agent for the wilt disease of safflower (Carthamus tinctorius Linn.), has been shown to produce diacetoxyscirpenol, T-2 toxin, fusaric acid and lycomarasmin in artificial media. These substances produced disease syndromes, similar to those seen after the natural infection, when administered in healthy plants. Diacetoxyscirpenol and T-2 toxin have been detected in diseased safflower plants after inoculating with the wilt pathogen. This study is the first demonstration of vivotoxicity of diacetoxyscirpenol.     

Structure and stereochemistry of brianolide,a new antiinflammatory diterpenoid from the Okinawan gorgonianBriareum sp.

Summary Brianolide (1), a new antiinflammatory diterpenoid of the briarein class, possessing a substituent at C-12 (R), has been isolated from the Okinawan gorgonianBriareum sp. Its structure has been established from spectral data in conjunction with a single crystal X-ray analysis.