Reactivity of cat skeletal muscle vessels to noradrenaline during induced respiratory alkalosis

Zusammenfassung Die respiratorische Alkalose steigert den Effekt des Noradrenalins auf Skelettmuskelgefässe. Eine durchschnittliche Steigerung des pH von 0.2 Einheiten wird benötigt, um eine merkliche Änderung herbeizuführen. Die vorliegenden Resultate lassen vermuten, dass die Steigerung in erster Linie auf die pH-Veränderung zurückzuführen ist und nicht auf die gleichzeitige Senkung der CO₂-Spannung.     

Changes induced by manganese in fish testis

Summary Exposure ofColisa fasciatus, a freshwater teleost, to 2500 mg/l manganese sulphate for 90 h caused decreased spermatogenic activity and hemorrhage in the testes.     

Rate of depletion of noradrenaline in some peripheral tissues induced by a reserpine injection

Zusammenfassung Nor-Adrenalin (NA) verschwindet nach einer Reserpininjektion im Uterus des Kaninchens langsamer als in anderen Organen: nach 12 h noch Nachweis von Aminen in den vasomotorischen Uterusnerven, nicht aber zum Beispiel in derGl. submandibularis. Tendenz zu gleicher Reaktion zeigt der Uterus des Meerschweinchens, nicht aber der Ratte, der Maus oder des Hamsters. Es wird der Schluss gezogen, dass verschiedene sympathische Nervenendigungen gleicher Aufgabe variierende Grundeigenschaften zeigen.

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This study was aided by grant NB 02854-04 from the United States Public Health Service.     

Changes in cellular noradrenaline fluorescence in the denervated rat superior cerical ganglion

Summary The microfluorimetrical investigation showed that in the principal perikarya of the rat superior cervical ganglion, after inhibition of noradrenaline-synthesis and unilateral preganglionic axotomy, the fluorescence of newly synthesized noradrenaline was most intense at the periphery of the perikarya of the intact side.The authors are deeply indebted to Mr H. Petermann, and to Mr B. Rombach, Ciba-Geigy Ltd. for their mathematical support.     

The effect of lidocaine on the secretion induced by cholera toxin in the cat small intestine

The intraluminal administration of lidocaine, a local anaesthetic agent, inhibits the net loss of fluid into the intestinal lumen produced by cholera toxin in the cat. It is suggested that the activation of a nervous reflex is involved in the pathogenesis of cholera.     

Depressor effects of muscarinic and non-muscarinic mediation induced by lateral hypothalamic stimulation in the cat

Transient sympathetically-mediated depressor effects were induced by stimulation of a small locus in the lateral hypothalamic peri-fornical region, medial to the fields of Forel. The ganglionic blocking agent, atropine methyl nitrate (ATMN), was used to show that muscarinic as well as non-muscarinic sympathetic ganglion receptor neurotransmission was involved. Evidence is presented that stimulation of this LH site co-activates a number of mechanisms and that depending on which of these are activated, the ganglionic blocking agent ATMN may either block, reverse or potentiate the depressor effect.     

The effect of lidocaine on the secretion induced by cholera toxin in the cat small intestine

Summary The intraluminal administration of lidocaine, a local anaesthetic agent, inhibits the net loss of fluid into the intestinal lumen produced by cholera toxin in the cat. It is suggested that the activation of a nervous reflex is involved in the pathogenesis of cholera.This research was sponsored by grants from the Swedish Medical Research Council (14X-2855), from the Swedish Society for Medical Sciences, from Magnus Bergvalls Stiftelse and from the Medical Faculty, University of Göteborg.     

Changes in cerebral blood supply caused by changes in the pressure drop along arteries to the brain of the cat

Zusammenfassung Bei der Katze kann der Druckabfall in den extra- und intrakraniellen Anteilen der Hirnarterien unter gewissen Bedingungen genügend gross werden, um die Hirndurchblutung in eindeutiger Weise zu beeinflussen. Schwankungen des Druckgradienten in den Arterien werden durch die arterielle Vasomotorik und Veränderungen der Durchströmung derjenigen Gewebe bedingt, die von den Aa. carotidae externae versorgt werden.     

Diltiazem prevents the damage to cultured aortic smooth muscle cells induced by hyperlipidemic serum

Diltiazem, a calcium antagonist, significantly reduced the increased 45Ca uptake and the number of dead cells in cultured aortic smooth muscle cells induced by hyperlipidemic serum.     

Diltiazem prevents the damage to cultured aortic smooth muscle cells induced by hyperlipidemic serum

Summary Diltiazem, a calcium antagonist, significantly reduced the increased⁴⁵Ca uptake and the number of dead cells in cultured aortic smooth muscle cells induced by hyperlipidemic serum.     

Respiratory influences upon depressor and pressor responses to stimulation of the aortic nerve in the decerebrate cat

Riassunto Le risposte circolatorie alla stimolazione elettrica del nervo aortico sono notevolmente modificate dalla ventilazione polmonare. In particolare le risposte a stimoli di intensità intermedia ed elevata, che attivano oltre a fibre pressocettive anche fibre chemocettive, divengono da ipotensive ipertensive durante ipoventilazione. Gli effetti dell'ipoventilazione sono sempre riprodotti sia dall'ipercapnia (respirazione con CO₂ 5–7% in O₂) sia dall'ipossia (respirazione di O₂ 5–8% in N₂).

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This research has been sponsored jointly by the Aeronautical Systems Division, ASD and the Office of Aerospace Research, OAR, through its European Office, Office of Aerospace Research, United States Air Force, under Contract No. AF 61 (052)-253, and by Consiglio Nazionale delle Ricerche.     

Alterations of free amino acids concentrations in cat brain induced by rapid eye movement sleep deprivation

Résumé La concentration de certains acides aminés libres au niveau du cerveau chez le chat change sous l'influence de la privation élective du sommeil paradoxal. Ces changements pourraient s'expliquer par l'augmentation d'excitabilité nerveuse associée à la privation élective du sommeil paradoxal.