共查询到20条相似文献,搜索用时 15 毫秒
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DNA-directed DNA polymerase activity in oncogenic RNA viruses 总被引:34,自引:0,他引:34
S Spiegelman A Burny M R Das J Keydar J Schlom M Travnicek K Watson 《Nature》1970,227(5262):1029-1031
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RNA dependent DNA polymerase activity in mammalian cells 总被引:18,自引:0,他引:18
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The structural basis for an essential subunit interaction in influenza virus RNA polymerase 总被引:1,自引:0,他引:1
Obayashi E Yoshida H Kawai F Shibayama N Kawaguchi A Nagata K Tame JR Park SY 《Nature》2008,454(7208):1127-1131
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Breaks in DNA stimulate transcription by core RNA polymerase 总被引:8,自引:0,他引:8
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RNA-dependent DNA polymerase in virions of RNA tumour viruses 总被引:240,自引:0,他引:240
D Baltimore 《Nature》1970,226(5252):1209-1211
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Prisoner's dilemma in an RNA virus 总被引:13,自引:0,他引:13
The evolution of competitive interactions among viruses was studied in the RNA phage phi6 at high and low multiplicities of infection (that is, at high and low ratios of infecting phage to host cells). At high multiplicities, many phage infect and reproduce in the same host cell, whereas at low multiplicities the viruses reproduce mainly as clones. An unexpected result of this study was that phage grown at high rates of co-infection increased in fitness initially, but then evolved lowered fitness. Here we show that the fitness of the high-multiplicity phage relative to their ancestors generates a pay-off matrix conforming to the prisoner's dilemma strategy of game theory. In this strategy, defection (selfishness) evolves, despite the greater fitness pay-off that would result if all players were to cooperate. Viral cooperation and defection can be defined as, respectively, the manufacturing and sequestering of diffusible (shared) intracellular products. Because the low-multiplicity phage did not evolve lowered fitness, we attribute the evolution of selfishness to the lack of clonal structure and the mixing of unrelated genotypes at high multiplicity. 相似文献
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Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota 总被引:12,自引:0,他引:12
Somatic hypermutation of immunoglobulin genes is a unique, targeted, adaptive process. While B cells are engaged in germinal centres in T-dependent responses, single base substitutions are introduced in the expressed Vh/Vl genes to allow the selection of mutants with a higher affinity for the immunizing antigen. Almost every possible DNA transaction has been proposed to explain this process, but each of these models includes an error-prone DNA synthesis step that introduces the mutations. The Y family of DNA polymerases--pol eta, pol iota, pol kappa and rev1--are specialized for copying DNA lesions and have high rates of error when copying a normal DNA template. By performing gene inactivation in a Burkitt's lymphoma cell line inducible for hypermutation, we show here that somatic hypermutation is dependent on DNA polymerase iota. 相似文献
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Identification of the herpes simplex virus DNA polymerase gene. 总被引:48,自引:0,他引:48