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Over the past 20 years, laboratory studies of genetically defined animal models of human essential hypertension have provided valuable information on the pathophysiology of this disturbance in cardiovascular regulation. Relatively fewer studies have examined the impact of preweaning factors on the developing cardiovascular system of hypertensive animals. In our laboratory studies, we have utilized two inbred genetically hypertensive models: the spontaneously hypertensive (SHR) rat and its Wistar/Kyoto (WKY) normotensive control strain as well as the Dahl hypertension-sensitive (SS/Jr) and hypertension-resistant (SR/Jr) strains. To manipulate the preweaning maternal environment, we have employed the technique of reciprocal cross-fostering of litters between hypertensive and matched normotensive mothers. Our findings to date point to the maternal environment as a powerful influence on the development of high blood pressure in genetically hypertensive rats. In general, hypertensive rats reared by normotensive foster mothers have significant reductions in arterial blood pressure in adulthood. Thus, the progression of hypertensive disease is not strictly predetermined by genotypic factors. Rather, a genetic predisposition to hypertension interacts with preweaning environmental factors to determine an animal's cardiovascular phenotype in adulthood. 相似文献
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R. McCarty M. A. Cierpial C. A. Murphy J. H. Lee C. Fields-Okotcha 《Cellular and molecular life sciences : CMLS》1992,48(4):315-322
Over the past 20 years, laboratory studies of genetically defined animal models of human essential hypertension have provided valuable information on the pathophysiology of this disturbance in cardiovascular regulation. Relatively fewer studies have examined the impact of preweaning factors on the developing cardiovascular system of hypertensive animals. In our laboratory studies, we have utilized two inbred genetically hypertensive models: the spontaneously hypertensive (SHR) rat and its Wistar/Kyoto (WKY) normotensive control strain as well as the Dahl hypertension-sensitive (SS/Jr) and hypertension-resistant (SR/Jr) strains. To manipulate the preweaning maternal environment, we have employed the technique of reciprocal cross-fostering of litters between hypertensive and matched normotensive mothers. Our findings to date point to the maternal environment as a powerful influence on the development of high blood pressure in genetically hypertensive rats. In general, hypertensive rats reared by normotensive foster mothers have significant reductions in arterial blood pressure in adulthood. Thus, the progression of hypertinsive disease is not strictly predtermined by genotypic factors. Rather, a genetic predisposition to hypertension interacts with preweaning environmental factors to determine an animal's cardiovascular phenotype in adulthood. 相似文献
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E A Volpe 《Experientia》1992,48(5):500-503
The cytotoxic activity (CTA) of activated peritoneal macrophages (MP) on variant lines of Syrian hamster embryo (HE) cells of differing malignant characteristics was studied. The target cells were a line of low-malignant cells resulting from spontaneous transformation of HE cells in vitro (STHE strain), and malignant variants selected from them in vivo (STHE-LM-4, STHE-LM-8, and STHE-75/18 strains). In addition, we used cells of the HET-SR-1 strain; these are HE cells transformed in vitro by a tumorigenic Rous sarcoma virus (Schmidt-Ruppin strain, RSV-SR), or the TU-SR strain induced by RSV-SR in vivo. Thioglycollate-elicited peritoneal MP from Syrian hamsters were activated in vitro with bacterial levan, LPS or MDP and used as effector cells. MP-mediated cytolysis was determined by means of a 42-h radioactivity release assay with 3H-thymidine-labeled target cells. We found that only the parental STHE cells were susceptible towards fully-activated MP-mediated CTA. All three of the in vivo-selected malignant variants of the STHE cell sublines, as well as the tumorigenic RSV-SR transformants, were resistant to cytolysis by activated MP. Non-activated thioglycollate-elicited MP did not lyse any of the tumor cells studied. 相似文献
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C Rampini C Dubois 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,284(24):2577-2580
The sensitivity of transformed EHSVi fibroblasts to the antibody-complement lytic system was evaluated, at various antibody concentrations (Ac), in conditions in which a variation of the lytic activity proportional to Ac3, 1 may be observed. This points out, not the expected cooperation between IgG molecules in activating C1 within a definite lytic unit, but a cooperation between the lytic units themselves, and therefore the existence of a cell defence. 相似文献
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Hogan C 《Cellular and molecular life sciences : CMLS》2012,69(2):203-213
The majority of human cancers are initiated when a single cell in an epithelial sheet becomes transformed. Cell transformation
arises from the activation of oncoproteins and/or inactivation of tumor suppressor proteins. Recent studies have independently
revealed that interaction and communication between transformed cells and their normal neighbors have a significant impact
on the fate of the transformed cell. Several reports have shown that various phenomena occur at the interface between normal
and transformed epithelial cells following the initial transformation event. In epithelia of Drosophila melanogaster, transformed and normal cells compete for survival in a process termed cell competition. This review will summarize current
research and discuss the impact of these studies on our understanding of how primary tumors emerge and develop within a normal
epithelium. 相似文献
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Ginsenosides, which were extracted from Panax ginseng C.A. Meyer, induced well the development of subcellular organelles in cultured Morris hepatoma cells (MH1C1). 相似文献
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Ultrastructural studies of Morris hepatoma cells reversely transformed by ginsenosides 总被引:2,自引:0,他引:2
H. Abe S. Arichi T. Hayashi S. Odashima 《Cellular and molecular life sciences : CMLS》1979,35(12):1647-1649
Summary Ginsenosides, which were extracted from Panax ginseng, C. A. Meyer, induced well the development of subcellular organelles in cultured Morris hepatoma cells (MH1C1).Acknowledgments. We wish to thank Mr H. Konishi, Mrs H. Makino, Mrs Y. Nakayabu and Miss N. Honjo for their excellent technical assistance. 相似文献
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Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts 总被引:1,自引:0,他引:1
Bergman AC Alaiya AA Wendler W Binetruy B Shoshan M Sakaguchi K Bergman T Kronenwett U Auer G Appella E Jörnvall H Linder S 《Cellular and molecular life sciences : CMLS》1999,55(3):467-471
Signalling via the protein kinase Raf-MEK-ERK pathway is of major importance for transformation by oncogenes. To identify
genes affected by inhibition of this pathway, c-JUN transformed rat fibroblasts were treated with a MEK1 inhibitor (PD98059) and subjected to two-dimensional gel electrophoresis
after cell lysis. Gene products with expression influenced by MEK1 inhibition were determined by mass spectrometry of fragments
from in-gel tryptic digestions. The expression of pirin, a nuclear factor I-interacting protein, was lowered after inhibition
of MEK1. Western blot analysis revealed increased expression of pirin in RAS and c-JUN transformed cells in the absence of PD98059. Inhibition of MEK1 also led to reduced expression of α-enolase, phosphoglycerate kinase, elongation factor 2 and heterogeneous nuclear ribonucleoprotein A3, the latter two being
detected as truncated proteins. In contrast, the level of ornithine aminotransferase was increased. We conclude that inhibition
of MEK1 results in major alterations of protein expression in c-JUN transformed cells, suggesting that this pathway is important for oncogene-induced phenotypic changes.
Received 30 December 1998; accepted 12 January 1999 相似文献
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M Ermonval M A Persuy M Fellous G Lespinats H G Suàrez A Kay P Nardeux R Cassingena 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(20):1579-1582
Mouse embryo cells, transformed in vitro by the transfer of chromosomes from HeLa human tumour cells, express a surface antigen (s) also found on HeLa cells. This antigen(s), which has been detected both by indirect immunofluoresence and by a 125I-protein A binding assay, is not an antigen(s) shared by both Human and Mouse cells. 相似文献
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Summary Based on the sample in this study (members of the Spina Bifida Association of America), there are approximately 2.15 times as many mothers with Rh-blood type than would be expected in a similar sized sample of the general population. 相似文献
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A. Albini G. Allavena H. Richter B. F. Pontz S. Parodi L. Santi 《Cellular and molecular life sciences : CMLS》1985,41(12):1591-1593
Summary SV40 virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant. 相似文献
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SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells 总被引:1,自引:0,他引:1
SV40-virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant. 相似文献
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Olfactory ensheathing cell phenotype following implantation in the lesioned spinal cord 总被引:5,自引:2,他引:3
Woodhall E West AK Vickers JC Chuah MI 《Cellular and molecular life sciences : CMLS》2003,60(10):2241-2253