‘The long-lost truth’: Sir Isaac Newton and the Newtonian pursuit of ancient knowledge

In the 1720s the antiquary and Newtonian scholar Dr. William Stukeley (1687-1765) described his friend Isaac Newton as ‘the Great Restorer of True Philosophy’. Newton himself in his posthumously published Observations upon the prophecies of Daniel, and the Apocalypse of St. John (1733) predicted that the imminent fulfilment of Scripture prophecy would see ‘a recovery and re-establishment of the long-lost truth’. In this paper I examine the background to Newton’s interest in ancient philosophy and theology, and how it related to modern natural philosophical discovery. I look at the way in which the idea of a ‘long-lost truth’ interested others within Newton’s immediate circle, and in particular how it was carried forward by Stukeley’s researches into ancient British antiquities. I show how an interest in and respect for ancient philosophical knowledge remained strong within the first half of the eighteenth century.     

Re-examining the impact of European astronomy in seventeenth-century China: a study of Xue Fengzuo’s system of thought and his integration of Chinese and Western knowledge

ABSTRACT

During the late Ming and early Qing period, Jesuit missionaries introduced European science into China, and thereby profoundly influenced the later development of Chinese astronomy. Not only did European astronomy become the official system of the Qing dynasty, but the traditional way to ‘attain up above’ by connecting the study of astronomy and Yi learning gradually fell into disuse. However, the astronomers in this period expressed different views on these two processes. As one of the most important early Qing astronomers, Xue Fengzuo’s case presents a distinctive and important example. Firstly, under the influences of both Chinese tradition and European science, Xue Fengzuo rebuilt the way to ‘attain up above’ based on his three-fold ‘calendrical learning’, i.e. calendrical astronomy, astrology and related pragmatic applications, through which he could realize the highest Confucian ideal. Secondly, he integrated Chinese and Western knowledge for all three aspects of his ‘calendrical learning’, instead of ceding the dominant position to Western methods. From Xue Fengzuo’s example, many of the complex effects of the encounter between different cultures and the process of knowledge transfer can be revealed.     

Making sense of Day 1 of the Two New Sciences: Galileo’s Aristotelian-inspired agenda and his Jesuit readers

This study proposes an explanation for the choice of topics Galileo addressed in Day 1 of his 1638 Two New Sciences, a section of the work which has long puzzled historians of science. I argue that Galileo’s agenda in Day 1, that is the topics he discusses and the questions he poses, was shaped by contemporary teaching commentaries on Books 3 through 8 of Aristotle’s Physics. Building on the insights and approach of theorists of reader reception, I confirm this interpretation by examining the response of professors of natural philosophy at the Jesuit Collegio Romano to Galileo’s text.     

What’s right about Carnap, Neurath and the Left Vienna Circle thesis: a refutation

This paper rejects as unfounded a recent criticism of research on the so-called left wing of the Vienna Circle and the claim that it sported a political philosophy of science. The demand for ‘specific, local periodized claims’ is turned against the critic. It is shown (i) that certain criticisms of Red Vienna’s leading party cannot be transferred to the members of the Circle involved in popular education, nor can criticism of Carnap’s Aufbau be transferred to Neurath’s unified science project; (ii) that neither with regard to Carnap nor to Neurath does the criticism raise points that either engage with the thesis proposed or stand up to closer scrutiny; (iii) that the main thesis attacked is just what I had warned the claim that the Vienna Circle had a political philosophy of science should not be understood as. The question whether theirs is ‘political enough’ today can and should be discussed without distortion of the historical record.     

Setting up a discipline, II: British history of science and “the end of ideology”, 1931-1948

For the history of science the 1940s were a transformative decade, when salient scholars like Herbert Butterfield or Alexandre Koyré set out to shape postwar culture by promoting new standards for understanding science. Some years ago I placed these developments in a tradition of enduring arts-science tensions and the contemporary notion that previous, “scientistic”, historical practices needed to be confronted with disinterested codes of historical craft (Mayer, 2000). Here, I want to further explore the ideological dimensions of the processes through which the academic study of science became institutionalized. Butterfield’s generation of science historians moulded perception of science in highly specific ways. Whereas the scientist-historians of the 1930s put scientific innovation into its socio-economic contexts, postwar accounts portrayed the birth of modern science as an intellectual revolution. Anti-Marxism formed a defining feature of the process by which the image of scientific work as a disinterested journey of the mind came to be institutionalized. Rather than spelling the end of ideology, appointments processes in the early Cold War years reveal disagreement about what science was to be invariably coextensive with dissent about social and political order. Rather than testifying to irreconcilable conflicts between interestedness and historical craft, the work of both the 1930s and 40s speaks of surprisingly productive relations between the two.     

Pierre Duhem’s epistemic aims and the intellectual virtue of humility: a reply to Ivanova

David Stump (2007) has recently argued that Pierre Duhem can be interpreted as a virtue epistemologist. Stump’s claims have been challenged by Milena Ivanova (2010) on the grounds that Duhem’s ‘epistemic aims’ are more modest than those of virtue epistemologists. I challenge Ivanova’s criticism of Stump by arguing that she not distinguish between ‘reliabilist’ and ‘responsibilist’ virtue epistemologies. Once this distinction is drawn, Duhem clearly emerges as a ‘virtue-responsibilist’ in a way that complements Ivanova’s positive proposal that Duhem’s ‘good sense’ reflects a conception of the ‘ideal scientist’. I support my proposal that Duhem is a ‘virtue-responsibilist’ by arguing that his rejection of the possibility of our producing a ‘perfect theory’ reflects the key responsibilist virtue of ‘intellectual humility’.     

Forecasting the Effects of a Canada–US Currency Union on Output and Prices: A Counterfactual Analysis

This paper is a counterfactual analysis investigating the consequences of the formation of a currency union for Canada and the USA: whether outputs increase and prices decrease if these countries form a currency union. We use a two‐country cointegrated model to conduct the counterfactual analysis, where the conditional forecasts are generated based on the Gaussian assumption. To deal with structural breaks and model uncertainty, conditional forecasts are generated from different models/estimation windows and the model‐averaging technique is used to combine the forecasts. We also examine the robustness of our results to parameter uncertainty using the wild bootstrap method. The results show that forming the currency union would probably boost the Canadian economy, whereas it would not have significant effects on US output or Canadian and US price levels. Copyright © 2013 John Wiley & Sons, Ltd.     

Changes in calpastatin localization and expression during calpain activation: a new mechanism for the regulation of intracellular Ca<Superscript>2+</Superscript>-dependent proteolysis

The amount of calpastatin directly available in cytosol is under the control of [Ca²⁺] and [cyclic AMP]. Prolonged calpain activation also promotes degradation of calpastatin. The fluctuation of calpastatin concentration in cell soluble fraction is accompanied by an initial decrease in calpastatin gene expression, followed by a fivefold increase in its expression when the inhibitor protein is degraded. This process can be conceptualized as a mechanism to regulate calpastatin availability in the cell. This conclusion is supported by the fact that calpain, the other component of this proteolytic system, undergoes changes in its levels of expression in a much more limited manner. Furthermore, this process can be observed both in cells exposed to different natural stimuli, or in other cell lines. Modification of calpastatin gene expression might represent a new tool for the in vivo control of the regulatory machinery required for the modulation of Ca²⁺-dependent proteolysis.Received 18 July 2003; received after revision 3 September 2003; accepted 23 September 2003