沃丽汀片治疗中心性浆液性脉络膜视网膜病变的临床观察

目的通过中心性浆液性视网膜脉络膜病变(central serous chorolretin Opathy, CSC)患者口服沃立汀片治疗前后的光学相干断层扫描(optical coherence tomography,OCT)图像的测量分析,评价沃立汀治疗CSC的疗效.方法选择门诊随访资料完整的CSC患者20例23眼,给予沃立汀片口服,每日三次,每次1. 5mg,在药物治疗前以及治疗后2周、4周、8周,16周进行OCT扫描并做图像测量分析.结果治疗后16周复查治愈20眼(87.0%),显效23眼(100%),无效0眼(0%).结论沃立汀片药效稳定,持久,使用安全,方便,应用治疗中心性浆液性脉络膜视网膜病变疗效肯定,确切.OCT能显示CSC的直观图像并能精确测量,对随访病情变化有客观指导意义.     

针刺联合明目地黄胶囊治疗中心性浆液性脉络膜视网膜病变的临床观察

目的 观察针刺联合明目地黄胶囊治疗中心性浆液性脉络膜视网膜病变(centralserouoschorioretinopathy,CSC)的临床疗效.方法 选择CSC患者64例(68眼),随机分为对照组和治疗组.对照组采用维生索C、肌苷、三磷酸腺苷等常规治疗,治疗组在对照组基础上加用明目地黄胶囊和针刺疗法,4周后观察疗效...     

盾构克泥效浆液成分与渗透扩散研究

克泥效工法常在盾构隧道近接既有建筑物穿越工程中被引进作为控制地层位移的一种辅助工法,克泥效浆液在地层的渗透扩散性对盾壳与地层间环向间隙填充效果有着重要影响,克泥效浆液的流变性能与其微观成分对其流动性有着重要影响。本文基于对克泥效浆液流变性能与微观成分分析,研究了浆液性能变化。进一步结合宾汉姆流体砂土渗流公式与数值计算模型,分析了浆液性能对渗透效果的具体影响,并验证数值模型可靠性与合理性。结果表明:(1)各组克泥效浆液样本在宾汉姆本构下的非线性回归系数均大于0.95,塑性黏度与屈服强度会随着水粉比的减小而增大。(2)克泥效浆液主要成分为石英、斜长石、伊利石、钾长石,随着A液水粉比的增加,克泥效水化产物斜长石增加,而伊利石的含量减小。(3)克泥效浆液会在25s左右占满环向间隙,而后再向地层中发生渗透扩散,地层中浆液体积分数增速随时间而减小,直至增速降为0。(4)随A液水粉比增大、地层渗透系数增加、注浆压力增加,克泥效在地层渗透距离均会增加。理论渗透值与数值模型计算值误差在各工况下的平均误差控制在10%以内。     

中心性浆液性脉络膜视网膜病变治疗新进展

中心性浆液性脉络膜视网膜病变（central serous chorioretinopathy,CSC）是一种常见的视网膜病,其病因不明,是一种自限性疾病,但病情迁延不愈,会导致患者视功能的损害.随着人们对本病的认识不断发展,更多眼科医生主张积极地治疗,笔者就CSC的治疗进展进行阐述.     

蒸压粉煤灰砌体墙片的非线性性能模拟

为了研究适用蒸压粉煤灰砌体模拟的损伤塑性模型,确定使用损伤塑性模型模拟时的参数设置,基于ABAQUS的损伤塑性本构(CDP)模拟了5片蒸压粉煤灰砌体墙片的加载试验。通过骨架曲线模拟值与试验值对比,验证了损伤塑性模型模拟的可靠性。同时进行了参数分析,比较了不同砂浆强度、不同竖向压应力时砌体墙片的非线性性能。结果表明,基于ABAQUS的损伤塑性模型能够较为准确模拟蒸压粉煤灰砌体墙片在外力作用下的非线性性能特征,砂浆强度、竖向压应力对墙片非线性性能影响显著。     

碱激发粉煤灰-矿渣灌浆材料的流变性与流动性

采用Brookfield R/S plus流变仪和Marsh筒分别研究了碱激发粉煤灰-矿渣灌浆材料的流变性和流动性,并探讨了硅酸钠溶液模数和固含量、矿渣掺量的影响;采用灰色关联度分析法探究了流变性与Marsh流动性之间的关联性.研究表明:下端出口内径为10 mm的Marsh筒适用于碱激发粉煤灰-矿渣灌浆材料的流动性测试;碱激发粉煤灰-矿渣灌浆材料为流变性指数大于1的剪切增稠浆液,流变性与Marsh流动性存在经时突变性;当水玻璃模数为1.7、水玻璃用量为18%、矿渣掺量为10%时,浆液具有良好的工作性能;浆液Marsh流动度与浆液屈服应力和塑性黏度之间的关联度均大于0.8,关联性良好,其中在20 s~(-1)剪切速率时流变性与Marsh流动性的关联性最好,可采用Marsh筒法来检测评价浆液的流变性.     

丙烯酸盐浆液的研究进展与发展方向

本文介绍了 2 0世纪 70年代以来国内外对丙烯酸盐浆液的研究和应用成果 ,认为丙烯酸盐浆液是一种在防渗性、流变性、粘结强度、毒性方面具有独特性能的防渗型化学浆液。文章对丙烯酸盐浆液研究的发展方向进行了探讨。     

田菁胶在纺织经纱上浆中的应用

研究田菁胶的上浆性能,测试了浆液、浆膜性能,并对添加田菁胶以降低混合浆中PVA的用量进行了浆液粘附力和浆纱测试.测试结果表明,浆液粘度稳定、浆膜柔韧,对纤维素纤维粘着力较大,田菁胶在经纱上浆中取代部分PVA,浆纱效果良好.为纺织厂在浆纱时提供参考.     

基于ChineseBert的中文拼写纠错方法

中文拼写错误主要集中在拼音相似和字形相似两个方面，而通用的预训练语言模型只考虑文本的语义信息，忽略了中文的拼音和字形特征.最新的中文拼写纠错（Chinese Spelling Correction,CSC）方法在预训练模型的基础上利用额外的网络来融入拼音和字形特征，但和直接微调预训练模型相比，改进的模型没有显著提高模型的性能，因为由小规模拼写任务语料训练的拼音和字形特征，和预训练模型获取的丰富语义特征相比，存在严重的信息不对等现象.将多模态预训练语言模型ChineseBert应用到CSC问题上，由于ChineseBert已将拼音和字形信息放到预训练模型构建阶段，基于ChineseBert的CSC方法不仅无须构建额外的网络，还解决了信息不对等的问题.由于基于预训练模型的CSC方法普遍不能很好地处理连续错误的问题，进一步提出SepSpell方法 .首先利用探测网络检测可能错误的字符，再对可能错误的字符保留拼音特征和字形特征，掩码对应的语义信息进行预测，这样能降低预测过程中错误字符带来的干扰，更好地处理连续错误问题.在三个官方评测数据集上进行评估，提出的两个方法都取得了非常不错的结果 .     

二氧化碳泡沫同步注浆液特性研究及成本分析

为探究CO2泡沫同步注浆液的性能及现场制备成本,通过正交试验和极差分析方法对CO2泡沫同步注浆液的最佳配比进行研究,对CO2在对同步注浆液的改性过程中的性能变化进行回归分析,并依托南京五塘广场隧道施工的现场浆液性能要求,利用多目标规划方法进行成本分析。结果表明：CO2泡沫同步注浆液最佳配比为水胶比0.8,粉灰比2.0,胶砂比0.5,膨水比0.16。回归拟合结果表明常规二次型回归模型更适合模拟CO2泡沫改性的同步注浆液的性能;通过MATLAB工具箱中的FMINCON函数进行多目标规划计算得出与现场浆液相同性能下CO2泡沫同步注浆材料成本更低。     

Improving the sintering performance of blends containing Canadian specularite concentrate by modifying the binding medium

Canadian specularite concentrate (CSC) possesses high total iron grade and low impurity content. However, due to the poor granulating performance and weak reactivity of CSC at high temperature, the proportion of CSC used in sintering blends is restricted. In this research, the effects of fine limonite, slake lime, and bentonite particles on the granulation performance of blends containing a high ratio of CSC were studied through granulation test. Based on the test results, the effects of modification of the binding medium on the sintering performance of blends containing a high ratio of CSC were revealed by the sintering pot test. Both the granulation property and sintering performance of blends with a high proportion of CSC were improved by modifying the binding medium.     

Optimal carrier-smoothed-code algorithm for dual-frequency GPS data

Carrier-smoothed-code （CSC） algorithm is an effective pseudorange multipath mitigation technique, which can alleviate the compu- tational burden and reduce the communication bandwidth needed for the transmission of GPS observations. This paper presents an improved Hatch filter and addresses the optimal CSC algorithm for dual-frequency GPS data based on the optimal parameter estimation theory. The smoothed observations have the same information content as that of the raw dual-frequency GPS data from which these are derived. Consequently, the optimal CSC algorithm is equivalent to the uncombined algorithm. Theoretical analyses show that the data orecision of the optimal CSC algorithm is better than that of Hatch filter and its imoroved version.     

Optimal carrier-smoothed-code algorithm for dual-frequency GPS data

Carrier-smoothed-code (CSC) algorithm is an effective pseudorange multipath mitigation technique, which can alleviate the computational burden and reduce the communication bandwidth needed for the transmission of GPS observations. This paper presents an improved Hatch filter and address the optimal CSC algorithm for dual-frequency GPS data based on the optimal parameter estimation theory. The smoothed observations have the same information content as that of the raw dual-frequency GPS data from which they are derived. Consequently, the optimal CSC algorithm is equivalent to the uncombined algorithm. Theoretical analyses show that the data precision of the optimal CSC algorithm is better than that of Hatch filter and its improved version.     

Comparison of CSC method and the B-net method for deducing smoothness condition

The first author of this paper established an approach to study the multivariate spline over arbitrary partition, and presented the so-called conformality method of smoothing cofactor (the CSC method). Farin introduced the B-net method which is suitable for studying the multivariate spline over simplex partitions. This paper indicates that the smoothness conditions obtained in terms of the B-net method can be derived by the CSC method for the spline spaces over simplex partitions, and the CSC method is more capable in some sense than the B-net method in studying the multivariate spline.     

中心性浆液性脉络膜视网膜病变病因及发病机制的研究进展

中心性浆液性脉络膜视网膜病变是由于视网膜色素上皮层（RPE）屏障功能障碍，脉络膜渗漏液进入视网膜神经上皮层下积存，致使神经上皮发生盘状脱离为特征的一种眼底疾病，其病因和发病机制尚不完全清楚，本文对近年来的研究进展做一综述．     

企业利益相关者利益与煤炭企业效益实证研究

采用多个能反映不同利益相关者利益的指标,应用Cross-section及时间序列方法和联立方程对煤炭企业效益与其利益相关者之间的关系进行了分析,并对Freeman利益相关者理论进行了论证,研究结果表明企业效益与其利益相关者之间存在着很强的定量关系。     

A novel strategy for cancer treatment: Targeting cancer stem cells

Cancer stem cell/tumor-initiating cell （CSC/TIC） is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recurrence and tumor resistance to radiotherapy and chemotherapy. At present, small molecule inhibitors and fusion proteins are widely used in the CSC-targeting strategy. Gene-virotherapy, which uses oncolytic adenovirus as a vector to mediate the expression of therapeutic gene, shows a significant superiority to other regimens of cancer treatment and has a good efficacy in the treatment of solid tumors. Thus, it is a promising choice to apply gene-virotherapy into the CSC-targeting treatment. Based on the molecular mechanism underlying CSC self-renewal, a series of effective strategies for targeting CSC have been established. This review will summarize the recent research progresses on CSC-targeting treatment.     

改进的色彩结构码彩色分割算法在数字化虚拟人研究中的应用

对色彩结构码（CSC）算法做了改进,将图像边界信息结合进CSC算法的连接过程,并以色度、饱和度、亮度（HSV）色彩模型为基础确定色彩差别．通过设定颜色差别和边界梯度的容忍闽值控制分割的深度．实验用中国虚拟人（VCH）和虚拟人计划（VHP）数据集的彩色切片图像进行分割．结果表明,分割结果比原算法更准确,而且克服了原算法因分割结果对容忍阈值非常敏感而难于取得合适的容忍闽值的缺点．