结核杆菌原发耐药间隔五年对比分析

目的 :探讨归口管理对原发耐药菌的影响。方法 :回顾分析 1994- 1995年度与 1998- 1999年度结核杆菌原发耐药情况。结果 :1998- 1999年度原发耐药率较 1994- 1995年度明显下降。结论 :我院通过五年归口管理 ,降低了原发耐药菌的比例 ,但仍需进一步加强归口管理力度 ,从而有效控制原发耐药菌的发生。     

后基因组研究与新药开发

传统的药物开发方法在很多方面受到制约，而新的生物技术以及计算机技术为药物开发提供了新的思路．应用现代生物学的理论和技术以及计算机技术来寻找药物作用的靶点，进行药物作用机制的研究以及进行新药毒理学和药动学的研究可以大大提高新药开发的效率．     

平交路口通行能力影响因素分析

本文针对国内城市交通以机动车和非机动车混行交通为主的现状，提出影响平交路口通行能力的五大因素。     

新建隧道近距离上跨既有线施工方案研究

依据深圳彩田路北延段工程新彩隧道北口段(拟建)近距离上跨厦深铁路梅林隧道两条隧道叠置的工程设计实例,运用有限元分析软件MIDAS-GTS进行三维模型数值分析,对比明挖暗埋法和暗挖法新建隧道施工时既有隧道的变形及内力变化规律,对既有隧道的安全性进行评价.结果表明:明挖方案与暗挖方案从技术安全角度皆可行,经过综合比较,推荐明挖隧道方案.将数值分析结果与工程实例相结合,提出了新建隧道与既有隧道之间中隔岩体的加固措施、临时边坡开挖时锚喷网的设计方案及施工过程中新建隧道及既有隧道的监控量测方案.     

Molecular mechanisms that confer antibacterial drug resistance

Antibiotics--compounds that are literally 'against life'--are typically antibacterial drugs, interfering with some structure or process that is essential to bacterial growth or survival without harm to the eukaryotic host harbouring the infecting bacteria. We live in an era when antibiotic resistance has spread at an alarming rate and when dire predictions concerning the lack of effective antibacterial drugs occur with increasing frequency. In this context it is apposite to ask a few simple questions about these life-saving molecules. What are antibiotics? Where do they come from? How do they work? Why do they stop being effective? How do we find new antibiotics? And can we slow down the development of antibiotic-resistant superbugs?     

对传球游戏的探讨

利用树图法对一种传球游戏进行分支讨论,得到一个通项公式,并给出其在染色问题中的应用.     

High-throughput decoding of antitrypanosomal drug efficacy and resistance

The concept of disease-specific chemotherapy was developed a century ago. Dyes and arsenical compounds that displayed selectivity against trypanosomes were central to this work, and the drugs that emerged remain in use for treating human African trypanosomiasis (HAT). The importance of understanding the mechanisms underlying selective drug action and resistance for the development of improved HAT therapies has been recognized, but these mechanisms have remained largely unknown. Here we use all five current HAT drugs for genome-scale RNA interference target sequencing (RIT-seq) screens in Trypanosoma brucei, revealing the transporters, organelles, enzymes and metabolic pathways that function to facilitate antitrypanosomal drug action. RIT-seq profiling identifies both known drug importers and the only known pro-drug activator, and links more than fifty additional genes to drug action. A bloodstream stage-specific invariant surface glycoprotein (ISG75) family mediates suramin uptake, and the AP1 adaptin complex, lysosomal proteases and major lysosomal transmembrane protein, as well as spermidine and N-acetylglucosamine biosynthesis, all contribute to suramin action. Further screens link ubiquinone availability to nitro-drug action, plasma membrane P-type H(+)-ATPases to pentamidine action, and trypanothione and several putative kinases to melarsoprol action. We also demonstrate a major role for aquaglyceroporins in pentamidine and melarsoprol cross-resistance. These advances in our understanding of mechanisms of antitrypanosomal drug efficacy and resistance will aid the rational design of new therapies and help to combat drug resistance, and provide unprecedented molecular insight into the mode of action of antitrypanosomal drugs.     

Analysis of multigrid parallelization on message passing computers

This paper studies the complexity of multigrid parallelization on message passing computers. Parallelization is by domain decomposition. An optimal strip decomposition is proposed. With natural ordering of the grid points, the strip decomposition leads to good processor utilization. The efficiency could be significantly improved. Better performances could be achieved by making use of Van der Vorst ordering.     

机非物理分隔道路上自行车超车事件模型

为了解自行车交通流中自行车超车行为特征,建立了机动车-非机动车物理分隔路段上自行车超车事件解析模型.根据自行车超车事件发生时车辆空间位置特征,将自行车超车事件分为自由超车事件、邻贴超车事件及受阻超车事件,并基于自行车交通流速度离散分布特征及自行车空间分布概率,建立了3类超车事件的解析模型.根据南京市8条典型机非物理分隔道路上自行车超车事件数调查结果,对模型进行标定与验证表明,所提出的自行车超车事件数计算结果符合真实情况.分析了该模型对于自行车交通流参数的敏感性,结果表明,路段内自行车交通流量、自行车运行速度、交通流速度标准差及路段车道数显著影响3类超车事件发生数量.