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1.
Transcriptional control signals in the genome of bovine papillomavirus type 1   总被引:16,自引:0,他引:16  
M S Campo  D A Spandidos  J Lang  N M Wilkie 《Nature》1983,303(5912):77-80
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研究GA-凸函数的Hermite-Hadamard型不等式和Fejér型不等式决定的差值。对二阶可微的GA-凸函数,给出这些差值的上下界。对一阶可微的GA-凸函数,给出由Hermite-Hadamard型不等式和Fejér型不等式构成的函数的单调性的充分条件。  相似文献   

7.
广义几何凸函数是η凸函数和GA凸函数的推广,笔者建立了广义几何凸函数的Hermite-Hadamard型不等式,推广了GA凸函数的Hermite-Hadamard型不等式。  相似文献   

8.
极大值函数的二阶方向导数   总被引:2,自引:0,他引:2  
对有限个光滑函数的极大值函数引入了一有效指标集,利用线性不等式组的相容性给出了一这一有效指标集的生成算法,从而得到这一类非光滑函数Chaney二阶广义方向导数的精确计算方法。  相似文献   

9.
广东地区宫颈癌组织HPV18L1基因的克隆及序列分析   总被引:1,自引:1,他引:0  
目的:了解广东地区地方株HFV18L1基因结构特点,为HPV感染的检测和基因工程疫苗的研制提供实验基础.方法:采用PCR技术从广东地区宫颈癌组织中扩增HPV18L1基因,克隆人毕赤酵母表达载体pPICZaB,测序并对HPV18L1基因进行序列分析.结果:广东地区分离株与德国标准株在核苷酸序列上有4处不同,其中3处由于核苷酸的改变,其编码的氨基酸也发生相应变化,与标准株的同源性为99.8%.与中国西安地区分离株比较有两处突变点相同.结论:广东地区HPV18L1分离株与德国标准株、中国其他地区分离株之间均存在差异.  相似文献   

10.
定义一个与超二次函数的第一个Hermite-Hadamard型不等式相关的二元函数,利用一阶和二阶导数,给出它的界的估计,也证明它在一定条件下具有准线性和单调性。  相似文献   

11.
Obradovic引入研究了非Bazilevic函数并讨论了它的解析性质,受到数学工作者的广泛关注.利用非Bazilevic函数定义了两类新的双单叶函数族,结合正实部解析函数的系数估计和微分从属理论,得到这些函数族的起始项a2和a3的系数估计,所得结果推广了一些已有的结论.  相似文献   

12.
双解析函数非正则型Hilbert边值问题   总被引:1,自引:1,他引:0  
研究双解析函数的非正则型Hilbert边值问题,给出该问题的可解性定理。  相似文献   

13.
A novel type of human papillomavirus associated with genital neoplasias   总被引:40,自引:0,他引:40  
The role of human papillomaviruses (HPVs) in the development of genital neoplasias has been well documented. The genomes of two HPV types, HPV16 and HPV18, have been found to be associated with about 70% of invasive carcinomas of the uterine cervix. As, under non-stringent hybridization conditions, HPV DNA sequences have been detected in about 90% of cervical carcinomas, it seems likely that additional HPV types are associated with these tumours. Here we report the molecular cloning and characterization of a novel HPV type, tentatively named HPV33, whose sequences have been detected in 4-8% of biopsies of genital intra-epithelial neoplasias and cervical invasive carcinomas, usually as free monomeric or oligomeric molecules. However, in one specimen of vulvar Bowen's disease, HPV33 DNA sequences were integrated in the host-cell genome. Thus, HPV33 probably represents an additional type of potentially oncogenic genital HPV.  相似文献   

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给出了区间值函数的Riemann型积分定义,它是直线上Aumann积分的推广.并利用实值函数的广义黎曼积分———Henstock积分对其进行了刻划.  相似文献   

15.
A common function for polyoma virus large-T and papillomavirus E1 proteins?   总被引:3,自引:0,他引:3  
P Clertant  I Seif 《Nature》1984,311(5983):276-279
Nucleotide sequencing has revealed a common genetic organization for three papillomaviruses: BPV-1 (bovine papillomavirus type 1), HPV-1 (human papillomavirus type 1a) and HPV-6 (human papillomavirus type 6b). Several open reading frames, corresponding to as yet uncharacterized proteins, were observed in these genomes in the region that is required for oncogenic transformation by BPV-1 and for plasmidial maintenance of its genome. The longest of these frames, E1, is also the most conserved between the three viruses; we have compared the amino acid sequence of its putative product ('E1 protein') with those of the large-T proteins of three polyoma viruses and report here significant homologies in their carboxy-terminal halves, extending for over 200 amino acids. Moreover, similar secondary structures were predicted in this region, especially in two blocks of homologous residues, which correspond in the large-T proteins of polyoma and simian virus 40 (SV40) viruses to sites involved in the ATPase and nucleotide-binding activities. These observations suggest that the papillomavirus E1 proteins might have a function in common with the polyoma virus large-T proteins (which are required for the initiation of viral DNA replication). As it was suggested recently that the E1 gene product is involved in maintaining the BPV-1 genome as a plasmid in transformed cells, we speculate that the structural features conserved in these otherwise very different viruses are general characteristics of eukaryotic proteins involved in the control of DNA replication.  相似文献   

16.
Size and location of the transforming region in human adenovirus type 5 DNA   总被引:59,自引:0,他引:59  
F L Graham  A J van der Eb  H L Heijneker 《Nature》1974,251(5477):687-691
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17.
本文研究了一类具有时滞的非连续函数的Bellman-Bihari型非线性积分不等式,在Gallo和Piccirillo的结果的基础上,增加了二元函数项,放弃对函数的单调性和可分离性要求.通过将不等式中的函数单调化和积分号外的函数作常量化,作者给出了不等式中未知函数的估计,进而将所得的不等式的估计用于研究一类脉冲微分方程的解的估计.  相似文献   

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利用数学归纳法研究了一类具有时滞的非连续函数 Bellman-Bihari 型积分不等式。与已有结果相比,所得结果无需非线性函数ω∈Θ族函数或ω∈Γ族函数。  相似文献   

19.
利用Stolz定理和夹逼定理计算一类特定型函数极限.在此基础上对函数形式进行推广,获得其几种一般形式的结果.拓宽和丰富了Stolz定理的应用范围.  相似文献   

20.
本文用pH电位法研究了HPDP的五级离解作用;测定了其逐级离解常数;计算了离解过程的热力学参数△G、△H、△S。同时对HPDP与金属离子的螯合能力进行了研究。  相似文献   

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