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Résumé On a démontré que la distension péricardiale produit des changements chronotropiques dans le cur de grenouille isolé en perfusion. Sur 26 curs, l'accélération cardiaque (18 a 148%) se produit dans 12 avec un volume de fluide péricardique atteignant 4 ml. Dans les 14 curs restant nous avons observé une bradycardie, des irrégularities de conduction, un blocage cardiaque et une arythmie. On en conclut que ces effects chronotropiques et les variations du paramètre d'impulsion sont dues aux changements dans l'activité du «pacemaker». 相似文献
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Zusammenfassung Herzen gesunder, erwachsener Ratten wurden mit Krebs-Henseleit-Bikarbonatlösung durchströmt (95% O25% CO2). Bei künstlich herbeigeführter Hypoxie (95% N25% CO2) erschienen die Herzmitochondrien innerhalb von 7 min bedeutend vergrössert und zu 25% miteinander verschmolzen. 相似文献
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Doxorubicin (DXR) (0.17 x 10(-4) M) induces an acute cardiotoxicity in isolated rat heart; there is a progressive widening of the S alpha T segment, with a decrease in force derivatives and in the coronary flow. Concurrent perfusion with fructose-1,6-diphosphate (FDP) (10(-5)-10(-4) M) dose-dependently reduces the S alpha T enlargement but fails to affect the reduction in force derivatives and coronary flow. The target of cardiac protection by FDP might be the ionic mechanisms underlying the action potential configuration. 相似文献
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Résumé Les ganglions lymphatiques perfusés sur place résistent à l'élévation du débit lymphatique; cette résistance peut favoriser le dévéloppement de l'dème local. 相似文献
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Summary The action of diazepam on the parallel fibres-Purkinje cell synapse was studied in a perfused frog cerebellum. Diazepam facilitates the excitatory input to Purkinje cells and hence increases the inhibition produced by Purkinje cells activity.Supported by a grant from the Israel Center of Psychobiology.This work is part of M. D. Thesis by Y. B. N. 相似文献
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E. Fugassa G. Gallo A. Voci R. Accomando 《Cellular and molecular life sciences : CMLS》1982,38(1):81-82
Summary The routine procedure for the isolation of rat liver induces a significant fall in RNA polymerase I and II activities which are rapidly restored to the control levels during perfusion. 相似文献
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Nocloprost, a new synthetic prostanoid, elicited a vasodilator action when given through the renal artery of the isolated perfused rabbit kidney. Lower concentrations of the compound inhibited the pressor response to sympathetic stimulation or to angiotensin II, but potentiated the pressor effect of exogenous noradrenaline. These results were taken as an evidence that nocloprost prevents the release of neurotransmitter by a presynaptic mechanism. 相似文献
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Summary Nocloprost, a new synthetic prostanoid, elicited a vasodilator action when given through the renal artery of the isolated perfused rabbit kidney. Lower concentrations of the compound inhibited the pressor response to sympathetic stimulation or to angiotensin II, but potentiated the pressor effect of exogenous noradrenaline. These results were taken as an evidence that nocloprost prevents the release of neurotransmitter by a presynaptic mechanism.This work was supported by a grant from the Turkish Scientific and Technical Research Council (TAG-578). Nocloprost is the gift of Dr E. Schillinger, Head of Biochemical Pharmacology, Schering AG Research Laboratories, Berlin, FRG. 相似文献
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W. H. Bannister 《Cellular and molecular life sciences : CMLS》1967,23(9):715-716
Zusammenfassung In Magenschleimhaut des Frosches wird das Nicotinamid-adenin-dinucleotid nur im oxydierten Zustand gefunden. Die Absonderung der Säure in der Schleimhaut scheint von der Konzentration des reduzierten Pyridinnucleotids abhängig zu sein.
This work was supported by a grant from the Smith Kline and French Foundation. 相似文献
This work was supported by a grant from the Smith Kline and French Foundation. 相似文献
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Chemically mediated cell-to-cell contractile activation in isolated frog atrial cardiac cells 总被引:1,自引:0,他引:1
Summary A dying single frog atrial cardiac cell liberates an unknown substance which diffuses away from the dying cell and activates contractile activity in other isolated intact single cardiac cells within the vicinity of the dying cell.This investigation was supported by US Public Health Service, National Institutes of Health Grant HL 18943 and a Kansas Heart Association Grant-In-Aid.We wish to thank Dr Alan Chapman of the Department of Anatomy for doing the scanning electron microscopy of the cardiac cells. 相似文献
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Summary Sodium salicylate and aspirin are known to have a glycogenolytic effect as judged by either the glycogen level or lactate production in perfused hearts of rats. In this work it was possible to demonstrate that phosphorylase a level was increased in the hearts subjected to the action of these drugs. 相似文献