Detection of a new mutation (1467-A) for the pedigree withmucopolysaccharidosis type Ⅱ from a Chinese family

Mucopolysaccharidosis type II (MPS II) is a disabling, fatal monogenic disease caused by abnormal metabolism of the mucopolysaccharides[1]. Gene mutation is the basic cause of MPS II and investigation of the IDS gene muta-tion is the premise for prenatal gene diagnosis and gene therapy. MPS II is worldwide distributed with high inci-dence and serious results. To study the IDS gene of Chi-nese MPS II patients is important not only in carrying out one-family policy but also in upraisi…     

The mutation network for the hemagglutinin gene from the novel influenza A （H1N1 ） virus

A mutation network for the hemagglutinin gene （HA） of the novel type A （H1N1） influenza virus was constructed. Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic. Based on the 658A and 1408T mutations in HA, the viruses evolving into this epidemic were divided into three categories, the Mexico, the transitional and the New York type. The three groups of viruses presented distinctive clustering features in their geographic distributions.     

一种新型Schiff碱双核Cu(II)配合物的合成与表征

合成了一种新型Schiff碱配体并采用常规法和模板法合成了其双核Cu(II)配合物.运用红外、紫外可见、荧光光谱、元素分析、电子喷雾质谱和电导率等测试方法对所合成的配合物进行了表征,推测了其组成和结构,讨论了结构与性质关系,并提出了提高反应产率的方法     

Drug release from a coated planar matrix with a super-saturation loading in the core (II)

The preparation and characterization of 5-fluorouracil/ethylene-vinyl alcohol copolymer (5-Fu/E- VAL) matrix coated with various polymeric materials are reported. The coating materials studied here include ethylene-vinyl alcohol copolymer (EVAL) , cellulose acetate (CA), poly-2-hydroxyethyl methacrylate (PHEMA) and poly-methyl methacrylate (PMMA) with different diffusivities and thicknesses. To validate the proposed model equations, these coat¬ed systems were investigated experimentally and quantitatively. The results show a good correlation between theoretical predictions and experimental data.     

Study on the binding mode of Mg（Sal2trien） with DNA

Polyamide could not only combine with DNA out- side but also inhibit expressing of gene[1]. At the same time, polyamide could coordinate many molecules. Ren et al.[2] found that [MgⅡ(dien)(OH)] can cleave pBR322DNA effectively in 2004. Liu et al.[3,4] f…     

首例t（8;20）易位的M2—ANLL白血病重组位点的初步研究

对临床上确认为Ｍ２－ＡＮＬＬ的病例，首先进行骨髓细胞染色体的核型分析，经Ｇ显带和Ｒ显色确定为ｔ（８；２０）（ｑ２２；ｐ２３）易位，是一种新的变异型，为进行分子生物学研究，分别设计引物，反转录扩增检测ＥＴＯ基因ｃＤＮＡ ３‘０端顺序和ＥＴＯ融合转录物检测为阴性，从分子水平上排除了经典的ｔ（８，２１）易位的可能性。说明了该病例为ｔ（８；２０）易位，ＥＴＯ基因受累的新变异型白血病。     

基于2,5-双(4-吡啶基)-1,3,4-噁二唑配体的钴高氯酸盐超分子配合物的一种新晶型研究(英文)

在丁二酸和三乙胺存在下,高氯酸钴与2,5-双(4-吡啶基)-1,3,4-口恶二唑(4-bpo)反应生成配合物[Co(4-bpo)2(H2O)4](4-bpo)2(ClO4)2(H2O)6(1)的一种新晶型:单斜晶系,P2/n空间群,晶胞参数为a=1.909 2(2)nm,b=0.699 7(8)nm,c=2.271 1(3)nm,β=98.462(2)o,V=3.000 6(6)nm3,Z=2.配位单元中的八面体钴离子处于结晶学反演中心,配位原子分别来自于赤道平面上的4个水分子和2个轴向吡啶氮原子.晶格水分子、4-bpo和高氯酸根位于单核配位阳离子[Co(4-bpo)2(H2O)4]2 的周围,并通过多种O-H…O及O-H…N氢键作用连接形成新颖的主-客体包合结构,其中游离的阴离子处于所形成的二维氢键层内和层间的空隙中.     

Theoretical study on magneto-structural correlation of trinuclear copper （II） complex with the hydroxo bridge and bidentate syn-syn carboxylate group

During the past decade, molecular magnetism has received much attention both experimentally and theo- retically. Especially, the study of magneto-structure correlation attracts a continuous interest due to its fun-damental role in the design of molecular-…     

计算(2~(k_1),2~(k_2))型二重(r_1,r_2)-循环矩阵全部特征值的快速算法

利用矩阵分块逐次降阶的方法 ,给出了计算 (2 k1 ,2 k2 )型二重 (r1 ,r2 ) -循环矩阵全部特征值的快速算法 ,证明了其乘除的计算量为 (k1 +k2 ) 2 k1 + k2 - 1 ,加减的计算量为 (k1 +k2 ) 2 k1 + k2 .