Pushing the resolution limit by interferometric localization microscopy

<正>With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research team led by Prof. Xu Tao (徐涛) at the National Laboratory of Biomacromolecules,CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, developed a new interferometric single molecule localization microscopy with fast modulated structured illumination,which was     

“One-two punch” strategy for the treatment of liver cancer

<正>With the support by the National Natural Science Foundation of China,the research team led by Prof. Qin Wen Xin (覃文新) at Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,provided a "one-two punch" approach to liver cancer therapy in which the first drug induces a vulnerability exploited by the second drug. This work was collaborated with Prof. RenéBernards at Netherlands     

Atomic-layered Au clusters on α-MoC as catalysts for the low-temperature water-gas shift reaction

正Subject Code:B03With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Ma Ding(马丁)from Peking University,Senior Scientist JoséA.Rodriguez from Brookhaven National Laboratory and Prof.Shi Chuan(石川)from Dalian University of Technology     

A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria

正With the support by the National Natural Science Foundation of China,the research team led by Prof.Zhang YuZhong(张玉忠)at the State Key Laboratory of Microbial Technology,Shandong University,discovered a new microbial interaction in the ocean,which was published in Nature communications (2020,11(1):285).Bacteria are ubiquitous in marine ecosystems and play a vital role in nutrient recycling in the microbial     

LATERAL FLORET 1 induced the three-florets spikeletin rice

正With the support by the National Natural Science Foundation of China,a study by the research group led by Prof.He Guanghua(何光华)from the Rice Research Institute,Southwest University demonstrates that LATERAL FLORET 1induces the"three-florets spikelet"in rice,which was published in PNAS(2017,114(37):9984-9989).     

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

正Subject Code:H30With the support by the National Natural Science Foundation of China,the research group led by Prof.Zhang Can(张灿)from China Pharmaceutical University made important progress in the chemotherapy of post-operative malignant glioma,which was published in Nature Nanotechnology(2017,12(7):692—700).     

Molecular mechanism of mitochondrial tethering mediated by MFN1

正Subject Code:C05With the support by the National Natural Science Foundation of China,the research team led by Prof.Gao Song(高嵩)from the State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou,recently reported the molecular mechanism of mitochondrial tethering by dynamin-related GTPase MFN1upon GTP binding and hydrolysis,in Nature(2017,542:372—376).     

Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex

<正>With the support by the National Natural Science Foundation of China,the research team led by Prof.Yu Yongchun(禹永春)at the Institutes of Brain Science,Fudan University,revealed the vital roles of electrical coupling in chemical synapse formation between interneurons,which was published in Nature Communications(2016,7:12229,DOI:10.1038).Although the excitatory neurons in the neocortex are electrically coupled only during early development,     

Extra strengtheningand work hardening in gradient nanotwinned metals

正With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Lu Lei(卢磊)from the Institute of Metal Research,Chinese Academy of Sciences and Prof.Gao HuaJian(高华健)from Brown University demonstrates an extra strengthening and work hardening in the gradient nanotwinned metals,which was published in Science (2018,362(6414):     

Measurements of strange nuclei:‘hypertriton’ and ‘antihypertriton’ mass and binding energy to probe the symmetry violation and neutron stars properties

正With the support by the National Natural Science Foundation of China,the research team led by Prof.Ma YuGang(马余刚)at Fudan University has achieved the precise measurements of the mass and binding energy of exotic anti-hyper-matter in relativistic heavy ion collisions,which was published in Nature Physics (2020,16:409—412).Symmetry plays a major role in the understanding of many aspects of the structure of matter at the     

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1

正With the support by the National Natural Science Foundation of China,the research team led by Dr.Zhou Qing (周青)at the Life Sciences Institute,Zhejiang University,identified an early-onset autoinflammatory disorder caused by heterozygous mutations in the gene encoding RIPK1,an important regulator of apoptosis,necroptosis and innate immune signalling pathways,which was published in Nature(2020,577:109—114).     

piRNA response to retroviral invasion of the koala genome

<正>With the support by the National Natural Science Foundation of China,the research team led by Prof. Weng Zhi Ping (翁志萍) at the School of Life Sciences and Technology,Tongji University,found that piRNAs were involved in the "innate genome"response to retroviral invasions at germline,which was published in Cell (2019,179:pp. 632—643). This work was done in collaboration with Prof. William Theurkauf’s lab at UMass Medical School and co-founded by the National Institutes of Health in the US.     

Coastal organisms trapped in Cretaceous amber

<正>With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research team led by Prof. Wang Bo (王博) at the Nanjing Institute of Geology and Palaeontology of the Chinese Academy of Sciences (NIGPAS) reported the first known ammonite trapped in amber,which was published in PNAS (2019,116(23):11345—11350).Most amber inclusions are organisms that lived in the forest. It is very rare to find sea life trapped in amber. The     

Citrus has S-RNase-based self-incompatibility:Evolution of self-compatibility by a mutant Sm-RNase

正With the support by the National Natural Science Foundation of China,the research team led by Asso.Prof.Chai LiJun(柴利军)at the Key Laboratory of Horticultural Plant Biology(Ministry of Education),Huazhong Agricultural University,uncovered the molecular mechanism of self-incompatibility in Citrus,which was published in Nature Plants (2020,6:131—142).     

Breakthroughs in microbial-fuel-cell anode material achievinghighpower density

正Supported by the National Natural Science Foundation of China,the team led by Prof.Liu ShaoQin(刘绍琴)from the School of Life Science and Technology,Harbin Institute of Technology,made progress in anode materials of microbial fuel cells,which was published in Advanced Materials (2018,30(22):     

Artificial molecular muscle actingin nanoscale

正Supported by the National Natural Science Foundation of China,the research group led by Prof.Qu DaHui(曲大辉)at the East China University of Science and Technology,realized the artificial molecular muscle in nanoscale,which was published in Chem (2018,4:2670—2684).Muscle acts as a key tissue in the animal body to transform bio-chemical energy into mechanical work by linear contraction/extension motion.To mimic this vital functionality of muscle tissue,synthetic chemists     

Controllable catalytic difluorocarbene transfer enables access to diversified fluoroalkylated arenes

<正>With the support by the National Natural Science Foundation of China,a study by the research group led by Prof.Zhang Xin Gang (张新刚) from the Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences demonstrates the first controllable catalytic difluorocarbene transfer reaction by the palladium catalyst,in which Prof.Kendall N. Houk from the University of California,Los Angeles is the co-corresponding author for the DFT calculations. Recently,this work was published in Nature Chemistry (2019,11:948).     

The detection of carbon monoxide in an extremely metal-poor galaxy

正Subject Code:A03A Chinese team led by Prof.Shi Yong(施勇)at the School of Astronomy and Space Science,Nanjing University,reported the first detection of emission from carbon monoxide in an extremely metal-poor galaxy,which was published in Nature Communication(2016,7:13789).This work is under the support by the National Natural Science Foundation of China.     

The genetic basis of inbreeding depression in potato

<正>With the support by the National Natural Science Foundation of China,the research team led by Prof.Huang SanWen (黄三文)at the Agricultural Genomics Institute at Shenzhen,Chinese Academy of Agricultural Sciences,deciphered the genetic basis of inbreeding depression in potato,which was published in Nature Genetics (2019,51:374—378).     

Highly efficient base editing in Staphylococcus aureus using an engineered CRISPR RNA-guided cytidine deaminase

正With the support by the National Natural Science Foundation of China,the research team directed by Prof.Ji QuanJiang (季泉江)at the School of Physical Science and Technology of ShanghaiTech University,developed a highly efficient single-base editing technique in Staphylococcus aureus,which was published in Chemical Science (2018,9:3248—3253).