Fatty liver disease caused by high alcohol-producing Klebsiella pneumoniae

<正>With the support by the National Natural Science Foundation of China,the research team led by Prof. Yuan Jing(袁静) from the Capital Institute of Pediatrics,Liu Di (刘翟) from Wuhan Institute of Virology,Chinese Academy of Sciences,and Yang Rui Fu (杨瑞馥) from the State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology. uncovered that an intriguing kind of gut bacterium,Klebsiella pneumoniae,capable of producing a large amount of alcohol in the body,could lead to nonalcoholic fatty liver disease (NAFLD),     

REG3A defect caused by hyperglycemia delays wound healing in diabetes

正Subject Code:H10With the support by the National Natural Science Foundation of China,National Key Research and Development Program of China,and National Program for Support of Top-Notch Young Professionals,the research team led by Prof.Lai Yuping(赖玉平)at Shanghai Key Laboratory of Regulatory Biology,School of Life Sciences,East China Normal University,uncovered a critical role of regenerating islet-     

A loss-of-function mutation in LIMA1 decreases intestinal cholesterol absorption and prevents cardiovascular disease

正Supported by the National Natural Science Foundation of China,a collaborative study by the laboratories of Dr.Song BaoLiang (宋保亮)from Wuhan University and Dr.Ma YiTong (马依彤)from the First Affiliated Hospital of Xinjiang Medical University demonstrates that a rare frameshift mutation in the LIMA1 gene promotes low plasma low-density lipoprotein cholesterol(LDL-C)and decreases intestinal     

A dominant role of internal climate variability in controlling Atlantic multidecadal variability during the past 1200 years

正Subject Code:D02With the support by the National Natural Science Foundation of China,a collaborative study by the research group led by Prof.Yang Bao(杨保)from the Key Laboratory of Desert and Desertification,Northwest Institute of Eco-Environment and Resources of the Chinese Academy of Sciences,and the     

免疫检查点抑制剂引起的心血管动脉粥样硬化事件及中西医防治策略

随着免疫检查点抑制剂在肿瘤治疗中的广泛应用,癌症患者的生存期得到有效延长,但随之而来的心脏毒性问题日渐凸显,其中冠状动脉疾病、心肌梗死和缺血性卒中等动脉粥样硬化性血管事件因起病急、预后差而引起学者的关注。文章系统阐述了免疫检查点抑制剂治疗引起的心血管动脉粥样硬化事件,产生这种心脏毒性的风险因素及风险评估,以及潜在的发生机制和中西医防治策略。     

免疫检查点抑制剂引起的心血管动脉粥样硬化事件及中西医防治策略

随着免疫检查点抑制剂在肿瘤治疗中的广泛应用,癌症患者的生存期得到有效延长,但随之而来的心脏毒性问题日渐凸显,其中冠状动脉疾病、心肌梗死和缺血性卒中等动脉粥样硬化性血管事件因起病急、预后差而引起学者的关注。文章系统阐述了免疫检查点抑制剂治疗引起的心血管动脉粥样硬化事件,产生这种心脏毒性的风险因素及风险评估,以及潜在的发生机制和中西医防治策略。     

RDD基序对口蹄疫Asia1型毒株感染力的影响

不同型口蹄疫病毒1D蛋白的βG和βH链之间都含有一个高度保守的RGD基序,其结合细胞受体,起始病毒感染.但本文通过对Asia1型FMDV的1D序列分析证实,田间毒株含有RGD和RDD基序(RGD中的G突变为D)的两种类型毒株.通过反向遗传技术制备了分别含有RGD和RDD基序的两种病毒,测定其生物学特性,并通过细胞感染力和乳鼠致病力比较这两种病毒感染力的差别.结果表明,含有RGD和RDD的毒株都具有感染性,含有RDD毒株的细胞感染力和乳鼠致病力比含RGD的高10倍左右,为进一步阐明RDD基序Asia1毒株的感染机制的分子基础奠定必要的基础.     

Molecular mechanism of mitochondrial tethering mediated by MFN1

正Subject Code:C05With the support by the National Natural Science Foundation of China,the research team led by Prof.Gao Song(高嵩)from the State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou,recently reported the molecular mechanism of mitochondrial tethering by dynamin-related GTPase MFN1upon GTP binding and hydrolysis,in Nature(2017,542:372—376).     

甲型H1N1流感病毒流行株基因组进化分析

2009年4月, 北美地区出现甲型H1N1流感疫情, 并且疫情快速扩散至欧亚非三大洲, 风险等级上升至5级. 截止至5月13日, 甲型H1N1流感病毒已扩散至33个国家和地区, 实验室确认病例5728例, 死亡61人. 从NCBI的IRV和GISAID的EpiFluDB数据库下载甲型H1N1流感病毒序列425条, 进行序列比对与进化分析. 分析结果显示: (ⅰ) 当前流行的甲型H1N1流感病毒是一个三重排A型流感病毒: HA, NA, MP, NP和NS来源于猪流感病毒; PB2和PA来源于禽流感病毒; PB1来源于人流感病毒. (ⅱ) 猪流感病毒的来源可细分为: HA, NP和NS来源于H1N1亚型经典猪流感毒株; NA和MP来源于H1N1亚型禽源猪流感毒株. (ⅲ) 甲型H1N1流感病毒在流行扩散过程中没有显著变异, 同时病毒基因组没有发生重排. 本文除了分析美国代表毒株A/California/04/2009(H1N1)外, 还以墨西哥代表毒株A/Mexico/4486/2009(H1N1)为主进行了同源性和进化分析, 地理范围相对较大, 分析结果更具科学性.     

甲型H1N1流感病毒北美毒株的分子特征

以10个甲型流感病毒北美毒株的基因PB2, PB1, PA, HA, NP, NA, NS和M进行遗传进化分析, 并用不同的软件对PB2, HA, NS1和M2蛋白氨基酸序列、糖基化位点及抗药性位点分析. 结果表明, 甲型流感病毒北美毒株的基因片段是一个来源于不同宿主、不同地域的重组株. HA蛋白氨基酸序列分析表明, 北美毒株HA蛋白的裂解位点氨基酸序列均为IPSIQSR↓G, 不具有高致病性流感病毒的特性, 同时NS1蛋白第92位氨基酸残基由天冬氨酸突变为谷氨酸(Asp→Glu), PB2蛋白氨基酸序列的第627位均为谷氨酸(E), 这些特性表明对人具有明显的亲和性, 但推测对人具有较低的致病力. M2蛋白的同源建模表明了北美毒株M2蛋白的药物敏感位点突变为抗药型位点, 推测北美毒株具有抗金刚烷胺类药物的结构特点, NA蛋白序列分析表明了北美毒株仍然对神经氨酸酶抑制剂类药物敏感. 这些研究结果对于我国预防和控制甲型流感北美毒株具有重要的参考价值.     

Inactivation of plasminogen activator inhibitor-1 by a small-molecule antagonist

Under a research project funded by the National Natural Science Foundation of China, Dr. Huang Mingdong, a professor of Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sci- ences （CAS）, and his colleagues published their research findings in Chem Biol （2013, 20（2） ：253--61）.     

Molecular basis of ADORA1 inhibition-mediated tumor immune evasion by regulating the ATF3-PD-L1 Axis

正With the support by the National Natural Science Foundation of China,the research team led by Prof.Chen Xiang (陈翔)and Prof.Liu Hong (刘洪)at the Xiangya Hospital,Central South University,uncovered the role of adenosine signaling pathway in cancer immunotherapy,which was published in Cancer Cell (2020,37:324—339)Immune checkpoint blockades have been intensively investigated in recent years and have led to     

DKK1 determines organotropism of breast cancer metastasis by regulating microenvironments

正Supported by the National Natural Science Foundation of China,a collaborative study by the laboratories of Dr.Hu Guohong(胡国宏)from Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences and Dr.Yang Qifeng(杨其峰)from Shangdong University demonstrates that Dickkopf1(DKK1)     

New insights into the fusion of inner mitochondrial membranes by Mgm1

正With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research team led by Prof. Hu JunJie (胡俊杰)at the National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,reported structural and functional analysis of dynamin-like GTPase Mgm1,which was published in PNAS (2020,Feb 10,Epub ahead of print).     

Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing

<正>With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,Prof.Liu Lin's laboratory at the School of Life Sciences,Nankai University,published their research findings in an article"Rif1 Maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing"in Developmental Cell(2014,29(1):7—19).     

一题激起层层浪

2001年高考,上海物理卷有这样一道题: 请将下面三位科学家的姓名按历史年代先后排序.____,____,____.任 选其中两位科学家,简要写出他们在物理学上的主要贡献____,____.     

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

<正>With the support by the National Natural Science Foundation of China and the Ministry of Science,the research team led by Dr.Lu Lu(陆路)and Dr.Jiang ShiBo(姜世勃)at Fudan University,in collaboration     

变电站GG-1A开关柜改造探讨

文章介绍了城网、农网改造过程中,不同变电站的GGIA开关柜的不同改造方法.