共查询到20条相似文献,搜索用时 62 毫秒
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R. K. Razdan A. J. Puttick B. A. Zitko G. R. Handrick 《Cellular and molecular life sciences : CMLS》1972,28(2):121-122
Zusammenfassung Die Synthese von (—)-1(7)-Tetrahydrocannabinol (THC) auf (—)-1(6) wird beschrieben. Das Hauptprodukt der oxidativen Zerstörung von (—)-1-THC ist Cannabinol. Beschleunigte Versuche der Luftoxidation von (—)-1-THC und (—)-1(6)-THC haben gezeigt, dass das letztere beständiger ist. Dieser Unterschied kann mit der Reaktivität des C3-benzylisch-allylischen Wasserstoffes in (—)-1-THC erklärt werden. 相似文献
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H. Nakamura K. Ishii Y. Yokoyama S. Motoyoshi C. Imazu M. Shimizu 《Cellular and molecular life sciences : CMLS》1979,35(3):369-370
Summary dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals. 相似文献
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M. Katayama K. Kato H. Kimoto S. Fujii 《Cellular and molecular life sciences : CMLS》1995,51(7):721-724
Racemic 4,4,4-trifluoro-3-(indole-3-)butyric acid (TFIBA) has been synthesized and shown to inhibitAvena coleoptile elongation. (S)-(+)-TFIBA (fig. 1), which was prepared by an enzymatic method and markedly promotes root growth of Chinese cabbage, lettuce and rice plants, is a novel fluorinated plant growth regulator. Activity of the (S)-(+)-enantiomer of TFIBA was 10-fold greater than that of the (R)-(–)-enantiomer in the first two plant species and 5-fold greater in rice. 相似文献
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dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals. 相似文献
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B. A. Berkowitz S. Spector A. Brossi A. Focella S. Teitel 《Cellular and molecular life sciences : CMLS》1970,26(9):982-983
Zusammenfassung Die optischen Isomeren von 6-Hydroxydopa wurden synthetisiert und ihr Effekt auf den Katecholaminspiegel verschiedener Organe in der Ratte bestimmt. Dem (–)-Isomeren gegenüber waren Herz und Nebennieren äusserst empfindlich und im Gehirn wurde der Norepinephrinspiegel erniedrigt.
B.A.B. is the recipient of a Roche Institute of Molecular Biology postdoctoral fellowship. 相似文献
B.A.B. is the recipient of a Roche Institute of Molecular Biology postdoctoral fellowship. 相似文献
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A. Scriabine C. T. Ludden L. S. Watson J. M. Stavorski G. Morgan J. J. Baldwin 《Cellular and molecular life sciences : CMLS》1979,35(5):653-655
Summary 2 new 4-trifluoromethylimidazole derivatives were found which lowered mean arterial pressure in renal and spontaneously hypertensive (SH) rats by the oral route. In SH rats, compounds A and B were 0.1 and 0.3 times, respectively, as potent as hydralazine. No tolerance development was observed in SH rats with either compound over a 1-week period. In anesthetized dogs, both compounds lowered arterial pressure and peripheral vascular resistance but increased cardiac output. By intraarterial administration, both compounds increased femoral arterial blood flow. These findings represent discovery of a new class of vasodilator drugs.Deceased, May 31, 1978. 相似文献
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P. A. Barrett Elizabeth Beveridge D. Bull I. C. Caldwell P. J. Islip R. A. Neal N. C. Woods 《Cellular and molecular life sciences : CMLS》1982,38(3):338-339
Summary The biological properties of a novel compound 353C with high activity againstTrypanosoma cruzi, are described. The compound was about 10 times and 20 times more effective than either benznidazole or nifurtimox respectively, in producing radical cure in mice. 353C had a long half-life and showed anti-trypanosomal properties when given to mice at weekly intervals. 相似文献
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A Scriabine C T Ludden L S Watson J M Stavorski G Morgan J J Baldwin 《Experientia》1979,35(5):653-655
2 new 4-trifluoromethylimidazole derivatives were found which lowered mean arterial pressure in renal and spontaneously hypertensive (SH) rats by the oral route. In SH rats, compounds A and B were 0.1 and 0.3 times, respectively, as potent as hydralazine. No tolerance development was observed in SH rats with either compound over a 1-week period. In anesthetized dogs, both compounds lowered arterial pressure and peripheral vascular resistance but increased cardiac output. By intraarterial administration, both compounds increased femoral arterial blood flow. These findings represent discovery of a new class of vasodilator durgs. 相似文献