LKB1 as the keyregulator of non-small cell lung cancer plasticity and therapeutic response

<正>Supported by the National Natural Science Foundation of China and the National Basic Research Program of China,a research team led by Prof.Ji Hongbin at Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,and Prof.Chen Haiquan from Shanghai Cancer Hospital of Fudan University,reported that LKB1inactivation elicits a redox imbalance to modulate non-small cell lung cancer     

Enantioselective cyanation of benzylic C—H bonds via copper-catalyzed radical relay

<正>With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research team led by Prof.Liu Guosheng(刘国生)at Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,and Prof.Shannon Stahl at the University of Wisconsin-Madison,discovered a copper-catalyzed radical relay pathway for enantioselective conversion of benzylic C—H bonds into     

Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma

正With the support by the National Natural Science Foundation of China,the research team directed by Prof.Xia JingLin (夏景林)at the Liver Cancer Institute,Zhongshan Hospital,Fudan University,and Prof.Chen LuoNan at Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,recently reported that CALML3as a dynamic network biomarker indicated pulmonary metastasis at the     

Structural determination of catalytically active subnanometer iron oxide clusters

<正>With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research team led by Prof.Si Rui(司锐)at Shanghai Synchrotron Radiation Facility,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,collaborated with the groups of Prof.Jia     

Drug target for the treatment of MRSA(a superbug)infections

<正>With the support by the National Natural Science Foundation of China and National Science and Technology Major Project,the research team led by Prof.Lan Lefu at the State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,and Prof.Li Jian(李剑)at the Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science     

Regulation of inflammation by the REGγ-proteasome

<正>With the support from the National Natural Science Foundation of China,the National Basic Research Program of China,and the ScienceTechnology Commission of Shanghai Municipality,the research teamled by Prof.Li Xiaotao(李晓涛)at the Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences,East China Normal University collaborated with Prof.Xiao Jianru at Changzheng     

Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis

<正>An international research team with multi-discipline expertise directed by Prof.Cui Rutao (major in biology)at the School of Medicine Boston University,Prof.Deng XianMing(邓贤明,major in medicinal chemistry)at the School of Life Sciences,Xiamen University,and Prof.Wang Peng (王鹏,major in clinical research)at Shanghai Cancer Center,Fudan University,recently reported a novel and viable     

Molecular mechanism for activityregulation of MLL-family methyltransferases

<正>With the support by the National Natural Science Foundation of China,the Chinese Academy of Sciences,the Ministry of Science and Technology of China,and the Basic Research Project of Shanghai Science and Technology Commission,the research teams led by Prof.Lei Ming(雷鸣)and Chen Yong at the National Center for Protein Science Shanghai,Institute of Biochemistry and Cell Biology,and Prof.LI     

Ion sieving in graphene oxide membranes via cationic control of interlayer spacing

正With the support by the National Natural Science Foundation of China,a collaborative study by the research groups led by Prof.Fang Haiping(方海平)from Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Prof.Wu Minghong(吴明红)from Shanghai Applied Radiation Institute,Shanghai     

High efficiency Pb-In binary metal perovskite solar cells

<正>With the support by the National Natural Science Foundation of China,the research team led by Prof.Liao Liangsheng(廖良生)at the Institute of Functional NanoSoft Materials(FUNSOM)of Soochow University collaborated with the research team led by Prof.Gao Xingyu(高兴宇)at Shanghai Institute of Applied Physics(SINAP)of Chinese Academy of Sciences,reported high efficiency Pb-In binary metal     

Artificial biosynthetic pathway design for β-valienamine

<正>With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research team led by Prof.Feng Yan(冯雁),collaborating with Prof.Bai LinQuan(白林泉)at the State Key Laboratory of Microbial Metabolism,School of Life ScienceBiotechnology,Shanghai Jiao Tong University,recently reported"De novo biosynthesis ofβ-valienamine in engi-     

New bubble-exfoliation route to prepare high-quality graphene with high yield

正With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research team led by Prof.Ding Guqiao(丁古巧)and Dr.He Peng(何朋)at Shanghai Institute of Microsystem and Information Technology,Chinese Academy of Sciences,achieved a     

Modular click chemistry libraries for functional screens using a diazotizing reagent

<正>With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research teams led by Prof. Dong Jia Jia (董佳家) and Prof. Karl Barry Sharpless at the Key Laboratory of Organofluorine Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,discovered the modular click chemistry libraries for function screens using a diazotizing reagent,which was published in Nature (2019,574:86—89).     

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China, Prof. Zhao Qiang＇s laboratory at Shanghai Institute of Materia Medica, Chinese Academy of Sciences, reported the crystal structure of the human P2Y12 receptor in complex with an anlithrombotic drug, which was published in Nature （2014, 509（7498）. 115-8）.     

Efficient asymmetric catalytic synthesis of antidepressant escitalopram

<正>With the support by the National Natural Science Foundation of China and the Thousand Talents Youth Program,the research team led by Prof.Tang Wenjun(汤文军)at the State Key Laboratory of Bio-organic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,and Prof.Deng Weiping(邓卫平)at the School of Pharmacy,East China University of Science and     

Dysregulated lung commensal bacteria drive interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles

<正>With the support by the National Natural Science Foundation of China,the research team directed by Prof.Qian YouCun (钱友存)at Shanghai Institute of Nutrition and Health,Chinese Academy of     

Central processing of itch in the midbrain reward center

<正>With the support by the National Natural Science Foundation of China,the research team jointly directed by Prof.Xu TianLe(徐天乐)at the Department of Anatomy and Physiology,Shanghai Jiao Tong     

Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides to aryl halides

正With the support by the National Natural Science Foundation of China and Chinese Academy of Sciences,the research team led by Prof.Mei TianSheng (梅天胜)at the State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,demonstrated the first example of a Ni-catalyzed electrochemical reductive relay cross-coupling of alkyl     

A SERS Optophysiological probe for the real-time mapping and simultaneous determination in a live mouse brain

<正>With the support by the National Natural Science Foundation of China and East China Normal University,the research team led by Prof.Tian Yang (田阳)at the Shanghai Key Laboratory of Green     

Non-equilibrium thermodynamic equality works at the single-spin level

正With the support by the National Natural Science Foundation of China and in collaboration with the researchers from Shanghai Jiaotong University and Oxford University,the research group led by Prof.Feng Mang(冯芒)from Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences demonstrates experimentally that a thermodynamic equality works at the single-spin level even in a non-