Influence of dithiocarb on the biliary excretion of paracetamol and bilirubin in rats.

In bile-fistula rats, the biliary elimination of conjugated paracetamol and conjugated bilirubin is diminished by simultaneous administration of dithiocarb. This dithiocarb effect could be the result of the interference with the glucuronidation of the compounds.     

Effect of glucose administration on bilirubin excretion in the rabbit

Summary The effect of i.v. infusion of glucose on the hepatic handling of bilirubin was examined in rabbits. A significant increase in the excretion of conjugated bilirubin into the bile was observed, accompanied by a decrease in bilirubinemia. Hepatic bilirubin concentrations were lowered and the UDP-glucose concentrations and liver UDP-glucuronosyl and UDP-glucosyl transferase activities increased.     

Effect of glucose administration on bilirubin excretion in the rabbit

The effect of i.v. infusion of glucose on the hepatic handling of bilirubin was examined in rabbits. A significant increase in the excretion of conjugated bilirubin into the bile was observed, accompanied by a decrease in bilirubinemia. Hepatic bilirubin concentrations were lowered and the UDP-glucose concentrations and liver UDP-glucuronosyl and UDP-glucosyl transferase activities increased.     

Formation of omega-muricholic acid and fecal excretion of biliary acids in rats]

Two groups of Rats which were fed the same diet, excreted fecal bile acids of different patterns: in one group, the feces contained a large amount of omega-muricholic acid and very little hydrodeoxycholic acid; in the other group the reversed composition was observed. The first group excreted more total bile acids than the second. This observation suggests that the formation of a large amount of omega-muricholic acid results in an increase in total bile acid fecal excretion.     

The biliary excretion of [3H] lysergic acid diethylamide in Wistar and gunn rats

Summary The biliary excretion of [³H] LSD was studied in Wistar and homozygous Gunn rats. In Wistar rats approximately 46% of the given dose was recovered from bile in 2.5 h whilst in the homozygous Gunn rat 26% was recovered in the same time period. In both strains the main metabolites were glucuronides.     

Influence of sex on the urinary bilirubin excretion at increased free plasma haemoglobin levels in whole dogs and in isolated normothermic perfused dog kidneys

Résumé Si le taux sanguin en hémoglobine libre dépasse les 50 mg/100 ml, l'excrétion rénale de la bilirubine est fortement augmentée chez le chien, tandis qu'elle reste faible chez la chienne. Les mêmes résultats sont obtenues par perfusion de reins isolés avec du sang hépariné ou défibriné.     

The biliary excretion of [3H] lysergic acid diethylamide in Wistar and Gunn rats.

The biliary excretion of [3H] LSD was studied in Wistar and homozygous Gunn rats. In Wistar rats approximately 46% of the given dose was recovered from bile in 2.5 h whilst in the homozygous Gunn rat 26% was recovered in the same time period. In both strains the main metabolites were glucuronides.     

The urinary excretion of bilirubin after increased plasma hemoglobin concentration in dogs

Résumé L'excrétion rénale de la bilirubine dans l'urine varie entre 0,1 et 0,8 mg par jour dans une série de 113 chiens normaux. Avec une concentration d'hémoglobine plasmatique libre, excédant 50 mg/100 ml, les auteurs ont remarqué une augmentation sensible de l'excrétion urinaire de la bilirubine, sans que les taux sanguin, de la bilirubine ni le clearance de la créatinine soient changés. Les résultats font supposer un métabolisme local de l'hémoglobine en bilirubine dans les reins.     

Transfer of bilirubin through the liver of Gunn rats

Résumé L'absence d'un T_m lors de perfusion en quantité croissante de bilirubine non conjuguée chez le rat Gunn, ainsi que la diminution de la concentration biliaire de la bilirubine totale lors d'infusion simultanée de bilirubine non conjuguée et de Novobiocine, suggèrent la possibilité d'un transfert passif de la bilirubine non conjuguée du sang dans la bile, à travers la cellule hépatique.     

Influence of post irradiation administration of methionine on the excretion of creatine,creatinine and N-methyl nicotinamide in urine of rats

Zusammenfassung Die Möglichkeit wurde geprüft, durch Zugabe von Methionin die Kreatin-, Kreatinin-, N'-Methylnicotinamid-und Stickstoffmengen nach Bestrahlung wieder herzustellen. Bei Methioninzugabe eine halbe Stunde nach Bestrahlung kehrte die Kreatin- und N-Methylnicotinamidmenge im Urin zur Norm zurück; wurde aber Methionin vor der Bestrahlung verabreicht, so blieben die Ausscheidungsmengen von Kreatin, Kreatinin und Stickstoff hoch.     

The effect of exogenous conjugated bilirubin on the urinary excretion of unconjugated14C-bilirubin by the Gunn rat

Resumen La inyección de bilirrubina conjugada a ratas Gunn con ligadura coledociana, produce un aumento de la excreción urinaria de bilirrubina C¹⁴ exógena o de la endógena sintetizada a partir de la inyección de ALA-C¹⁴ en dichos animales. Dicho aumento fue probado por la cristalización de la bilirrubina radioactiva de muestras de orina y por la radioactividad presente en el azopigmento A separado por cromatografía sobre papel. El aumento de pigmento I, demostrado en el suero por partitión química y en la orina por columna cromatográfica de fase inversa, permiten suponer la formación de un complejo de bilirrubina no conjugada radioactiva y de bilirrubina conjugada, como mecanismo del pasaje mencionado.

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This work was supported by grants from the Consejo Nacional de Investigaciones Científicas y Técnicas, República Argentina, National Institutes of Health, Bethesda, Md., USA and Ministerio de Salud Pública y Bienestar Social de la Provincia de Santa Fe, República Argentina.     

Influence of diuretics on renal calcium excretion

Zusammenfassung Die renale Kalziumausscheidung wird bei einmaliger i.v. Zufuhr von Aminophyllin, Furosemid, Etacrynsäure, Azetazolamid und Chlorothiazid erhöht. Dies kann nicht nur durch die erhöhte Natriumausscheidung erklärt werden, sondern muss mit dem direkten tubulären Kalziumtransport im Zusammenhang stehen.     

Increased bilirubin conjugation in the liver and intestinal mucosa of phenobarbital treated rats

Resumen Se estudió el efecto del fenobarbital sobre la conjugación de la bilirrubina en ratas Wistar y Gunn heterocigotas sometidas a la infusión continua de bilirrubina no conjugada. Los resultados obtenidos permiten suponer que el fenobarbital es capaz de estimular la conjugación de la bilirrubina tanto en el hígado como en la mucosa intestinal de ratas con deficiencia parcial de glucuronil transferasa.