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Zusammenfassung In vitro Experimente mit14C-markiertem, gereinigtem Aflatoxin zur Untersuchung der Bindung von Aflatoxin B1 und G1 an verschiedene Serumproteine ergaben, dass Aflatoxin B1 hauptsächlich mit-Globulin, G1 dagegen vorwiegend mit Albumin bindet.
This work was supported by part by a grant from the China Medical Board of New York, Inc., and was performed during one of us (S.S.L.) received a class C. research award from the National Science Council, Republic of China. 相似文献
This work was supported by part by a grant from the China Medical Board of New York, Inc., and was performed during one of us (S.S.L.) received a class C. research award from the National Science Council, Republic of China. 相似文献
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Binding of catechol derivatives to human serum proteins 总被引:2,自引:0,他引:2
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K. K. Maggon T. A. Venkitasubramanian 《Cellular and molecular life sciences : CMLS》1973,29(10):1210-1211
Résumé Un examen préliminaire fait avec une préparation d'Aspergillus parasiticus est rendu évidente la conversion de l'aflatoxine B en G. Il est probable que l'aflatoxines B1 est le précurseur biogénétique d'autres aflatoxines produite par le champignon.
K. K. M. is grateful to the Council of Scientific and Industrial Research, New Delhi, India, for the award of a Senior Research Fellowship. 相似文献
K. K. M. is grateful to the Council of Scientific and Industrial Research, New Delhi, India, for the award of a Senior Research Fellowship. 相似文献
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Metabolism of aflatoxins B1 and G1 by Aspergillus parasiticus 总被引:7,自引:0,他引:7
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M Baudry J P Clot V Boutroux R Michel 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1978,286(18):1323-1325
The rT3-binding and human serum proteins was directly studied with tracer doses of radioactive rT3. Polyacrylamide gel electrophoresis showed 125I-rT3 added to human serum was distributed among two proteins: albumin (carrying 57% of tracer rT3) and TBPA )22%). No binding was observed to TBG, protein binding T4. 相似文献
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Riassunto Sieri di uomo e di ratto sono stati incubati con C14-l-triptofano e sottoposti a elettroforesi su gel di poliacrilamide. Nel siero umano la radioattività si è localizzata nelle frazioni albuminica, prealbuminica e macroglobulinica. Nel siero di ratto il C14-l-triptofano si è localizzato nella zona delle albumine, -globuline e macroglobuline. 相似文献
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Centchroman, a non-steroidal antifertility agent showed a low affinity (Kd = 13.19 X 10(-6) M) and nonsaturable binding to human plasma. Centchroman did not compete either with sex hormone binding globulin or corticosteroid binding globulin. Polyacrylamide gel electrophoresis and temperature dependent binding characteristics revealed that the protein responsible for centchroman binding to human plasma resembles albumin. 相似文献
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R. L. Hunter J. Juntunen A. Olkkonen 《Cellular and molecular life sciences : CMLS》1971,27(8):984-984
Zusammenfassung Normale Serumproteine wurden mittels Elektromagnetophorese in Zellulose-Azetatgel ausgeführt, wobei keine Trennung der einzelnen Proteine erfolgte. Es stellte sich heraus, dass Serumproteine keine paramagnetischen Eigenschaften aufweisen. 相似文献
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A. K. Srivastava A. Agnihotri V. P. Kamboj 《Cellular and molecular life sciences : CMLS》1984,40(5):465-466
Summary Centchroman, a non-steroidal antifertility agent showed a low affinity (Kd=13.19×10–6 M) and nonsaturable binding to human plasma. Centchroman did not complete either with sex hormone binding globulin or corticosteroid binding globulin. Polyacrylamide gel electrophoresis and temperature dependent binding characteristics revealed that the protein responsible for centchroman binding to human plasma resembles albumin.Acknowledgment. The authors are grateful to Dr. Nitya Nand for his interest in this investigation. CDRI Communication No. 3333. 相似文献
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Zusammenfassung Normale und abnorme Seren sowie gereinigtes menschliches Serumalbumin und Serumglobulin, wurden vor und nach Ultraschalleinwirkung auf elektrophoretisches Verhalten untersucht. Die Unterlagen deuten auf eine Bildung aussergewöhnlicher Komplexe zwischen gewissen Serumproteinen, wahrscheinlich-Globulin und Albuminfraktionen, durch ultrasonische Frequenzen hin. 相似文献
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Berton A Selvais C Lemoine P Henriet P Courtoy PJ Marbaix E Emonard H 《Cellular and molecular life sciences : CMLS》2007,64(5):610-620
Matrix metalloproteinase-7 (MMP-7, matrilysin- 1) modulates crucial biological events by processing many epithelial cell surface-associated
effectors. We addressed MMP-7 interaction with human epithelial cells and its resulting activity. In human endometrium, a
model of controlled tissue remodeling, proMMP-7 was diffusely immunolocalized inside epithelial cells, whereas MMP-7 delineated
their entire plasma membrane. Endometrial explants preferentially retained active MMP-7, but not proMMP-7. Endometrial epithelial
cells and carcinoma cells from various tissues bound active MMP-7. Endometrial carcinoma-derived Ishikawa cells showed high
affinity (KD
of ~2.5 nM) and capacity (~260 000 sites per cell) for MMP-7. MMP-7 binding decreased by extracting membrane sterols or interfering
with heparan sulfate proteoglycans, and was abrogated by tissue inhibitors of metalloproteinase-2 (TIMP-2) or synthetic MMP
inhibitors. Bound MMP-7 not only remained fully active towards a macromolecular substrate but also became resistant to TIMP-2.
We conclude that MMP-7-selective targeting to the plasma membrane of epithelial cells promotes its activity by conferring
resistance to TIMP-2.
A. Berton, C. Selvais: These authors contributed equally to this work.
P. J. Courtoy, E. Marbaix, H. Emonard: These authors contributed equally to the supervision of this work.
Received 20 September 2006; received after revision 30 November 2006; accepted 18 January 2007 相似文献
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R. M. Nalbandian R. E. Michel I. Mader 《Cellular and molecular life sciences : CMLS》1968,24(10):1006-1007
Zusammenfassung Normale Serumproteine wurden mittels zweistufiger Elektromagnetophorese in Polyacrylamidgel, einer neuen Technik, aufgetrennt, wobei die Trennung auf Grund der paramagnetischen Eigenschaften der einzelnen Proteine erfolgt.
Supported by William Beaumont Hospital Research Institute in Affiliation with the Research Laboratories, General Motors Corporation and Department of Pathology, School of Medicine, Wayne State University. 相似文献
Supported by William Beaumont Hospital Research Institute in Affiliation with the Research Laboratories, General Motors Corporation and Department of Pathology, School of Medicine, Wayne State University. 相似文献
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R. Grinberg 《Cellular and molecular life sciences : CMLS》1965,21(12):729-729
Résumé Etude de la propriété qu'ont les protéines pituitaires solubles dans l'eau de lier la thyroxine d'indice I-131. L'électrophorèse au pH 8,6, en utilisant comme tampons le véronal et le tris-maléate, de même que l'autoradiographie sur bandes de papier montrent que ces protéines lient la thyroxine I-131 dans une zone correspondant à la fraction des globulines du sérum humain. 相似文献
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M G Sandor D Lods R Kerdiles A Maurois 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1975,281(4):329-331
Sera of healthy students (from Academy of Paris) aged between 18 and 30 years were collected with a view to routine clinical testing. 50 samples each representing the pooled sera of 400 individuals were investigated by evaluating 7 proteins for each pooled sample. Calculations of standard deviations showed that there existed a significant reproductibility of less than 2% for the population as a whole. These pooled sera representing 20 000 individual blood samples are proposed as a standard of human serum proteins. 相似文献