Green chemistry: C-C coupling and asymmetric reduction by innovative catalysis

A catalytic method has been developed, which allows aryl halides to couple with various electron-rich olefins to give 1,1’-substituted olefins. The palladium-catalysed coupling in ionic liquid solvent proceeds with high efficiency and remarkable regioselectivity without the need for any costly or toxic halide scavengers. Parallel to this, an environmentally-appealing method for the asymmetric reduction of ketones has been established, with which a variety of chiral alcohols can be accessed with high enantioselectivity in water with no need for any organic solvents. The same chemistry has been explored for the reduction of aldehydes, which is shown to be fast and highly chemoselective. These methods add new tools to the armoury of synthetic chemists.     

一个绿色微型有机合成实验:离子液体中3-乙酰基香豆素的合成

介绍了一个在离子液体中采用串联法合成3-乙酰基香豆素的绿色有机合成实验.碱性离子液体氢氧化1-丁基-3-甲基咪唑([bmIm]OH)在合成中具有双重功能,在作为反应溶剂的同时又作为反应的催化剂使用.反应物水杨醛与乙酰乙酸乙酯首先发生克脑文格反应,生成的产物紧接着发生分子内酯交换反应得到3-乙酰基香豆素.该串联反应是一个典型的高效、绿色的合成方法,本实验内容新颖、操作简单、所需试剂价廉易得,适合作为高年级本科生有机合成实验.     

pH值对液相合成YVO4及Tm∶YVO4晶体原料的影响

经过X射线粉末衍射和红外光谱测定比较 ,提出了液相合成YVO4 及Tm∶YVO4 的最佳条件 ,应将溶液的 pH值控制在 7左右 .使用该法合成的原料用提拉法可成功地生长出 10mm× 2 0mm～ 35mm× 4 0mm的大尺寸优质单晶 ,而且剩料经多次使用仍可生长出优质单晶