Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease： a meta-analysis

Objective： Many investigations have studied the associations between matrix metalloproteinase-9 （MMP-9） C1562T polymorphisms and coronary artery disease （CAD）. However, the conclusions of these studies were incon- sistent. Therefore, this study was aimed at clarifying the association between MMP-9 C1562T polymorphisms and CAD in a large-scale meta-analysis. Methods： The PubMed and Embase databases were retrieved to collect all pub- lications on the association between MMP-9 C1562T polymorphisms and CAD. Then the odd ratios （ORs） and 95% confidence intervals （95% CIs） for C1562T TT＋TC versus CC genotype between CAD and the control groups were evaluated. Subgroup analysis was also performed according to different races. The meta-analysis was performed by Stata 10.0. Results： Sixteen case-control studies were included in our meta-analysis, involving 11032 CAD patients and 4628 non-CAD controls. Compared with C allele carriers, East Asian T allele carriers TT＋TC had a significantly higher risk of CAD （OR=1.43; 95% CI： 1.03-1.99; P=0.031）; however, there were no significant associations in Western populations （OR=1.06; 95% CI： 0.96-1.18; p=0.240） or West Asians （OR=1.13; 95% CI： 0.75-1.70; P=-0.565）. When further analyzing the association between C1562T polymorphisms and myocardial infarction （MI, the most serious type of CAD）, the risk of TT＋TC genotype versus CC genotype for MI was significantly higher for the overall （OR=1.21; 95% C1： 1.04-1.40; P=0.012） and for East Asians （OR=1.58; 95% C1： 1.26-1.97; P=0.000） but not in Western populations （OR=1.12; 95% CI： 0.99-1.26; P=0.078）. Conclusions： Our meta-analysis suggested an obvious ethnic difference in the association between MMP-9 C1562T polymorphisms and CAD. MMP-9 C1562T polymorphism was significantly related to CAD in East Asians. However, no significant associations were observed in either West Asians or Western populations.     

Integrative Chinese and western medicine on atherosclerosis of coronary heart disease： what are the new control strategies？

How to control and prevent atherosclerosis （AS） remains a global issue that needs to be deeply dis- cussed. The innovation concept of AS and coronary heart disease （CHD） in western medicine provides a good opportunity to develop the traditional Chinese medicine etiology and new control strategies accordingly. This arti- cle reviewed and refined the updated control strategies of AS of CHD integrated Chinese and western medicine based on the innovation concept and therapeutic guideline of AS and CHD during the last 10 years.