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In the past ten years, great breakthroughs have been achieved in the nuclear reprogramming area. It has been demonstrated
that highly differentiated somatic cell genome could be reprogrammed to a pluripotent state, which indicates that differentiated
cell fate is not irreversible. Nuclear transplantation and induced pluripotent stem (iPS) cell generation are the two major
approaches to inducing reprogramming of differentiated somatic cell genome. In the present review, we will summarize the recent
progress of nuclear reprogramming and further discuss the potential to generate patient specific pluripotent stem cells from
differentiated somatic cells for therapeutic purpose.
Supported by the National High Technology Research and Development Program of China (Grant No. 2005AA210930) 相似文献
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Pang ZP Yang N Vierbuchen T Ostermeier A Fuentes DR Yang TQ Citri A Sebastiano V Marro S Südhof TC Wernig M 《Nature》2011,476(7359):220-223
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高浩其 《厦门大学学报(自然科学版)》1996,35(4):550-555
以搅拌槽间歇动力学方法研究TBP树脂吸附苯酚的粒内扩散,有限差分法解变边值条件的偏微分方程组.实验所得不同条件下的表观粒内扩散系数与温度和树脂上TBP含量有关.以此法计算的液相浓度随时间的变化与实验值相符. 相似文献
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Song K Nam YJ Luo X Qi X Tan W Huang GN Acharya A Smith CL Tallquist MD Neilson EG Hill JA Bassel-Duby R Olson EN 《Nature》2012,485(7400):599-604
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A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. 总被引:15,自引:0,他引:15
A Finkelstein C F Kostrub J Li D P Chavez B Q Wang S M Fang J Greenblatt Z F Burton 《Nature》1992,355(6359):464-467
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Specific binding of the transcription factor sigma-54 to promoter DNA. 总被引:11,自引:0,他引:11
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M G Peterson J Inostroza M E Maxon O Flores A Admon D Reinberg R Tjian 《Nature》1991,354(6352):369-373
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J Sommerville 《Nature》1984,310(5974):189-190
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Most proteins are insensitive to the presence of anaesthetics at concentrations which induce general anaesthesia, while some are inhibited by certain agents but not others. Here we show that, over a 100,000-fold range of potencies, the activity of a pure soluble protein (firefly luciferase) can be inhibited by 50% at anaesthetic concentrations which are essentially identical to those which anaesthetize animals. This identity holds for inhalational agents (such as halothane, methoxyflurane and chloroform), aliphatic and aromatic alcohols, ketones, ethers and alkanes. This finding is all the more striking in view of the fact that the inhibition is shown to be competitive in nature, with anaesthetic molecules competing with substrate (luciferin) molecules for binding to the protein. We show that the anaesthetic-binding site can accommodate only one large, but more than one small, anaesthetic molecule. The obvious mechanism suggested by our results is that general anaesthetics, despite their chemical and structural diversity, act by competing with endogenous ligands for binding to specific receptors. 相似文献
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Structure and regulatory function of plant transcription factors 总被引:4,自引:0,他引:4
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P H Romeo M H Prandini V Joulin V Mignotte M Prenant W Vainchenker G Marguerie G Uzan 《Nature》1990,344(6265):447-449