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Zusammenfassung Es wird gefunden, dass 1-Aminocyclopentan-1-Carboxylsäure (ACPC) die Bildung humoraler und zellgebundener Antikörper in verschiedenen Tierarten hemmt. ACPC ist überdies fähig, die chronische zelluläre Phase des Entzündungsprozesses zu unterdrükken. ACPC hat keine peripher pharmakologischen Angriffspunkte und wirkt offenbar nur auf zelluläre, lymphoide Elemente, welche für Entzündung und Allergie verantwortlich sind. Aufgrund dieser Eigenschaften dürfte ACPC bei Homotransplantationen und immunologischen Krankheiten Verwendung finden. 相似文献
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Wang H Song W Hu T Zhang N Miao S Zong S Wang L 《Cellular and molecular life sciences : CMLS》2011,68(12):2129-2139
Regulation of apoptosis at various stages of differentiation plays an important role in spermatogenesis. Therefore, the identification
and characterisation of highly expressed genes in the testis that are involved in apoptosis is of great value to delineate
the mechanism of spermatogenesis. Here, we reported that Fank1, a novel gene highly expressed in testis, functioned as an anti-apoptotic protein that activated the activator protein 1
(AP-1) pathway. We found that Jab1 (Jun activation domain-binding protein 1), a co-activator of AP-1, specifically interacted
with Fank1. Reporter analyses showed that Fank1 activated AP-1 pathway in a Jab1-dependent manner. Fank1 overexpression also
increased the expression and activation of endogenous c-Jun. Further study showed that Fank1 inhibited cell apoptosis by upregulating
and activating endogenous c-Jun and its downstream target, Bcl-3. This process was shown to be Jab1 dependent. Taken together,
our results indicated that by interacting with Jab1, Fank1 could suppress cell apoptosis by activating the AP-1-induced anti-apoptotic
pathway. 相似文献
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A. Anastasi L. Bernardi G. Bertaccini G. Bosisio R. de Castiglione V. Erspamer O. Goffredo M. Impicciatore 《Cellular and molecular life sciences : CMLS》1968,24(8):771-773
Riassunto Vengono descritte le proprietà di una serie di peptidi sintetici affini alla ceruleina e si discutono brevemente i rapporti fra attività e struttura.
A. Anastasi, V. Erspamer andR. Endean, Experientia23, 699 (1967).
This work was in part supported by grants from the Consiglio Nazionale delle Ricerche, Roma. 相似文献
A. Anastasi, V. Erspamer andR. Endean, Experientia23, 699 (1967).
This work was in part supported by grants from the Consiglio Nazionale delle Ricerche, Roma. 相似文献
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K. K. Maggon T. A. Venkitasubramanian 《Cellular and molecular life sciences : CMLS》1973,29(10):1210-1211
Résumé Un examen préliminaire fait avec une préparation d'Aspergillus parasiticus est rendu évidente la conversion de l'aflatoxine B en G. Il est probable que l'aflatoxines B1 est le précurseur biogénétique d'autres aflatoxines produite par le champignon.
K. K. M. is grateful to the Council of Scientific and Industrial Research, New Delhi, India, for the award of a Senior Research Fellowship. 相似文献
K. K. M. is grateful to the Council of Scientific and Industrial Research, New Delhi, India, for the award of a Senior Research Fellowship. 相似文献
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N. Imamura O. Saito H. Dohy T. Ogiu 《Cellular and molecular life sciences : CMLS》1981,37(12):1339-1340
Summary T-cell leukemia was induced at a high rate in female Fischer rats by continuous oral administration of 1-propyl-1-nitrosourea. No association of oncorna viruses were found in the leukemogenesis.The authors are greatly indebted to Professor K. Yokoro of the Department of Pathology, Research Institute for Nuclear Medicine & Biology, for his valuable suggestions. This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan. 相似文献
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Metabolism of aflatoxins B1 and G1 by Aspergillus parasiticus 总被引:7,自引:0,他引:7
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Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product Calcipressin 1 (or RCAN1) in disease 总被引:5,自引:0,他引:5
The DSCR1 (Adapt78) gene1 is transiently induced by stresses to temporarily protect cells against further potentially lethal challenges. However, chronic
expression of the DSCR1 (Adapt78) gene has now been implicated in several pathological conditions including Alzheimer’s disease, Down syndrome and cardiac
hypertrophy. Calcipressin 1 has been shown to function through direct binding and inhibition of the serine threonine protein
phosphatase Calcineurin. Pharmacological inhibition of calcineurin, by the immunosuppressive drugs cyclosporin A and FK506,
affects a wide variety of diseases. It is, therefore, likely that this endogenous calcineurin inhibitor, calcipressin 1, may
also play a role in a variety of human diseases.
1Please note that the mammalian DSCR1 gene is also called Adapt78 or RCAN1, and its protein products have been named Calcipressin1, MCIP1 and RCAN1. A proposal to adopt a single gene name of RCAN1 and a protein name RCAN1 (for Regulator of Calcineurin) has been endorsed by the HUGO Gene Nomenclature Committee, but final
approval must await agreement from a majority of researchers in the field.
Received 2 March 2005; received after revision 27 May 2005; accepted 19 July 2005 相似文献
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Zusammenfassung In vitro Experimente mit14C-markiertem, gereinigtem Aflatoxin zur Untersuchung der Bindung von Aflatoxin B1 und G1 an verschiedene Serumproteine ergaben, dass Aflatoxin B1 hauptsächlich mit-Globulin, G1 dagegen vorwiegend mit Albumin bindet.
This work was supported by part by a grant from the China Medical Board of New York, Inc., and was performed during one of us (S.S.L.) received a class C. research award from the National Science Council, Republic of China. 相似文献
This work was supported by part by a grant from the China Medical Board of New York, Inc., and was performed during one of us (S.S.L.) received a class C. research award from the National Science Council, Republic of China. 相似文献
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Binding of aflatoxins B1 and G1 to human serum proteins 总被引:1,自引:0,他引:1
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W. D. Johnson H. D. Law R. O. Studer 《Cellular and molecular life sciences : CMLS》1969,25(6):573-574
Zusammenfassung Es wird über die Synthese von 1-Deamino-bradykinin, 9-Decarboxy-bradykinin und 1-Deamino-9-decarboxy-bradykinin und über deren biologische Aktivität berichtet. Nach dem verwendeten Testsystem scheint die endständige Carboxylgruppe für die Aktivität bedeutsamer zu sein als die endständige Aminogruppe.
See H.Schröder and K.Lübke,The Peptides (Academic Press, New York 1966), vol. 2, p. 65.
Part of the PhD Thesis of W. D.Johnson. 相似文献
See H.Schröder and K.Lübke,The Peptides (Academic Press, New York 1966), vol. 2, p. 65.
Part of the PhD Thesis of W. D.Johnson. 相似文献
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Synthesis of SP1-glycoprotein by the human placenta was directly demonstrated, by in vitro translation of RNA extracted from full term and from early placentas in a cell-free wheat germ system followed by specific immunoprecipitation of the radioactively labeled nascent peptides. De novo synthesized SP1-glycoprotein in both RNA preparations accounted for 1-1.3% of total protein synthesis. 相似文献
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Rosy El Ramy Najat Magroun Nadia Messadecq Laurent R. Gauthier François D. Boussin Ullas Kolthur-Seetharam Valérie Schreiber Michael W. McBurney Paolo Sassone-Corsi Françoise Dantzer 《Cellular and molecular life sciences : CMLS》2009,66(19):3219-3234
Poly(ADP-ribose) polymerase-1 (Parp-1) and the protein deacetylase SirT1 are two of the most effective NAD+-consuming enzymes in the cell with key functions in genome integrity and chromatin-based pathways. Here, we examined the
in vivo crosstalk between both proteins. We observed that the double disruption of both genes in mice tends to increase late
post-natal lethality before weaning consistent with important roles of both proteins in genome integrity during mouse development.
We identified increased spontaneous telomeric abnormalities associated with decreased cell growth in the absence of either
SirT1 or SirT1 and Parp-1 in mouse cells. In contrast, the additional disruption of Parp-1 rescued the abnormal pericentric
heterochromatin, the nucleolar disorganization and the mitotic defects observed in SirT1-deficient cells. Together, these
findings are in favor of key functions of both proteins in cellular response to DNA damage and in the modulation of histone
modifications associated with constitutive heterochromatin integrity. 相似文献
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Summary Synthesis of SP1-glycoprotein by the human placenta was directly demonstrated, by in vitro translation of RNA extracted from full term and from early placentas in a cell-free wheat germ system followed by specific immunoprecipitation of the radioactively labeled nascent peptides. De novo synthesized SP1-glycoprotein in both RNA preparations accounted for 1–1.3% of total protein synthesis.Acknowledgment. The authors thank Drs A. Nirapatpongporn, V. Sirivasin and Professor H.F. Lodish for kindly providing placental tissues and wheat germ respectively. This work was supported by The Rockefeller Foundation (RF-8031).W.H. was supported by a Graduate Studies Fellowship, Mahidol University. 相似文献