支气管动脉灌注化疗治疗中晚期肺癌效果评价

目的：探讨支气管动脉内化疗物灌注（BAI）治疗中晚期肺癌的临床效果,方法：对临床确诊的中晚期肺癌88例病人进行支气管动脉内化疗药物灌注（BAI）,化疗药物组合依据不同的病理类型选择不同的化疗药物,结果：本组病例完全缓解（CR）17例,部分缓解（PR）52例,稳定（S）15例,进展4例,病例显效（CR＋PR）69例（69／88）,有效（CR＋PR＋S）84例（84／88）,结论,支气管动脉内灌注化疗药物（BAI）治疗中晚期肺癌疗效确切,近期疗效显著。     

原发性肺癌经支气管、胸廓内动脉联合化疗的疗效观察

目的 对原发性肺癌经支气管动脉联合胸廓内动脉灌注化疗和单纯支气管动脉灌注化疗进行疗效对比，以期对介入治疗肺癌提高认识。方法 对48例经介入疗法治疗原发性肺癌的资料进行回顾分析，对联合胸廓内动脉化疗和单纯支气管动脉化疗分组后进行疗效评估。结果 ①联合胸廓内动脉组共32例，其中部分缓解21例，稳定7例，进展4例；单纯支气管动脉化疗16例，其中部分缓解5例，稳定8例，进展3例；②化疗后胸背部疼痛及避部皮肤红肿、坏死等副反应在联合胸廓内动脉组32例中出现19例，在单纯支所管动脉组16例中出现4例。结论 ①联合胸廓内动脉组化疗后有效率高于单纯支气管动脉化疗组，有统计学意义；②联合胸廓内动脉化疗后胸背部疼痛及局部皮肤红肿、坏死等副反应发生率高于单纯支气管动脉组。     

支气管动脉造影和动脉化疗治疗肺癌

对不能手术切除的肺癌目前还没有更有效的治疗方法，全身性化疗血液中药物浓度低．而副作用大．1965年Vialaonte等开始应用支气管动脉选择性药物，随插管技术的发展．在国外已广泛被采用，国内这方面工作起步较晚．近一二年才有个别报告，我院自1986年8月才开始应用．Seldenger法股动脉穿刺插管对5例晚期肺癌患者进行10次支气管动脉插管(其中一例因病情变化而来进行治疗）．插管成功率100%．化疗成功率90%．     

经支气管动脉及其他肿瘤供血动脉同时灌注化疗治疗晚期肺癌

部分晚期肺癌有双重或异位动脉供血。本文报道了9例有双重供血动脉的晚期肺癌,经所有肿瘤供血动脉灌注化疗药物后,疗效满意。我们认为在晚期肺癌的动脉灌注化疗中,多支动脉供血的问题应引起足够的重视。     

介入治疗肺癌伴肋骨转移26例报告

自1993年以来，我们对历例肺场伴有肋骨转移的患者施行了支气管动脉化疗药物灌法术及肋间动脉化疗药物灌注术，效果较好，现报告如下：l临床资料1．l资料本组历例，男17例，女9例，年龄36－71岁，平均sl．4岁。26例肺癌患者均伴有不同程度的肋骨转移Q中心型肺切19例，周围型肺癌7例。患者均表现不同程度咳嗽，咳痰，多中带血，胸痛。1．2方法选用美国C00K公司生产的5．OF肺导管，采用Seldiget法，在局麻下经皮服动脉穿刺插管，分SIJ选插到支气管动脉，肋间动脉内造影。了解肿挠的供血、分支情况，有无变异及和脊闪动脉共干等。确定无误…     

术中支气管动脉与肺动脉灌注化疗对预防肺癌术后复发、转移的对比研究

目的 选择更有效的灌注方法，为肺癌的综合治疗提供新的治疗途径。方法 通过术中支气管动脉与肺动脉分别灌注5－氟尿嘧啶（5－FU），其靶器官中5－FU的质量浓度，标本用高效液相层析仪检测（HPLG）。结果 5－FU在支气管动脉灌注组的质量浓度明显高于肺动脉组，有显著的统计学意义（P＜0．001），血浆中的5－FU的质量浓度甚微。结论 术中支气管动脉灌注化疗可使靶器官含有较高的药物浓度，且全身毒副作用明显小于肺动脉灌注组。     

动脉插管化疗栓塞术治疗晚期妇科恶性肿瘤

评价髂内动脉分支动脉灌注化疗药物栓塞或栓塞治疗晚期妇科恶性肿瘤的疗效;对31例晚期妇科恶性肿瘤进行髂内动脉靶分支动脉进行化疗药物灌注和栓塞;31例恶性肿瘤中CR:3例;PR:15例;SD:10例;PD:3例;总有效率(CR+PR):58.0%(18/31)。半年存活31例100%,1年存活30例96.7%,2年存活21例67.7%,3年存活16例51.6%;髂内动脉分支化疗栓塞治疗晚期妇科恶性肿瘤,是一种安全有效的方法。     

肺癌介入治疗模拟实验研究中药液灌注率的检测方法

通过检测血药混合液的电导率值得其药物摩尔浓度,进而通过合理的方法和公式求得进入支气管动脉的药液灌注率．同时,进行了肺癌支气管动脉介入治疗的模拟实验,对药液灌注率检测方法和公式作了实验验证．     

晚期卵巢癌术中行髂内动脉灌注化疗研究进展

卵巢癌的治疗中化疗占有很重要的位置,多数情况下手术很难将残留灶和转移结节彻底清除干净,均有赖于化疗药物进行辅助治疗.一种新型的新辅助化疗,即卵巢癌肿瘤细胞减灭术术中行髂内动脉灌注化疗逐渐应用于临床,其优点将手术与化疗同时进行,避免了很多传统静脉给药与腹腔化疗的不足,并有着良好的初步临床疗效.现就晚期卵巢癌术中行髂内动脉灌注化疗方面的研究进展做一简要综述.     

心率变化对肺癌介入治疗药物灌注率的影响

肺癌介入治疗技术与血流动力学有着非常密切的关系.岑人经等人发现在支气管动脉入口附近存在一个药物自然灌注区,在此区域内药液可以高度集中,且沿靶动脉均匀扩散至瘤体内.采用智能化心血管循环模拟装置进行肺癌介入治疗模拟实验,测定了心率、血压和心输出量等生理参数变化对自然灌注区大小和形状的影响.本文中重点讨论了心率变化对肺癌介入治疗药物灌注率的影响.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

On the Thermodynamic Limit for Responses to Static Electromagnetic Fields

For molecular systems,the quantum-mechanical treatment of their responses to static electromagnetic fields usually employs a scalar-potential treatment of the electric field and a vector-potential treatment of the magnetic field.Although the potential for each field separately is associated with the choice of an(unphysical)origin,the precise choice of the origin for the electrostatic field has little consequences for the results.This is different for the     

An affordable accurate evaluation of the binding conformations predicted by molecular docking studies in bio-system

Franck-Condon factors bridge the gap between theoretical modeling and experimental observations for molecular electronic spectroscopy and electron transfer.Under the displaced harmonic oscillator approximation,multidimensional Franck-Condon factors are decomposed into a product of many one-dimensional(1D)Franck-Condon(FC)factors,and each 1D-FC factor is associated with one Huang-Rhys factor that determines the leading contribution of     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with     

Journal of Donghua University ( English Edition) Contents of Volume 31

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