复方黄柏颗粒对养殖场常见致病菌的体外抑菌实验

本研究的目的是为了探讨新型复方中兽药复方黄柏颗粒对养殖场中常见致病菌的体外抑菌效果,结果表明:复方黄柏颗粒对金黄色葡萄球菌、大肠杆菌、嗜水气单胞菌、甲型副伤寒沙门氏菌和多杀性巴氏杆菌的最小抑菌浓度(MIC)分别为15.625 μg/mL、125μg/mL、125μg/mL、31.25μg/mL、62.5μg/mL,最小杀菌浓度(MBC)分别为＞1000μg/mL、250μg/mL、250μg/mL、250μg/mL、1000μg/mL,抑菌圈直径呈浓度依赖关系,与MIC结果基本吻合.复方黄柏颗粒具有明显的抑菌效果,同时也为其使用提供了理论依据.     

迷迭香酸对三种常见细菌抑菌活性的研究

迷迭香酸是一种植物来源的天然化合物,具有抑菌活性.以三种金黄色葡萄球菌、托拉斯假单胞杆菌和单增李斯特菌为研究对象,检测迷迭香酸对其最低抑菌浓度(MIC)、最低杀菌浓度(MBC)和杀菌曲线.实验结果表明,金黄色葡萄球菌25923的MIC和MBC分别为:1.0和1.5mg/mL;金黄色葡萄球菌8325-4的MIC和MBC都是1.5mg/mL;金黄色葡萄球菌ATCC29213的MIC和MBC分别为:1.5和2.0mg/mL;托拉斯假单胞杆菌MIC和MBC均为:2.0mg/mL;单增李斯特菌MIC和MBC为:1.0和1.5mg/mL.     

CTAB包被的不同形态纳米金的制备及其抗菌性能研究

本文以CTAB为包被试剂合成了球形、棒状和三角形三种不同形态的纳米金颗粒,研究了它们对金黄色葡萄球菌(Staphylococcusaureus,S.aureus)和大肠杆菌(Escherichiacoli,E.coli)杀菌性能的差异.通过平板计数法和浊度法;确定了它们对两种菌的最小杀菌浓度(minimum bactericidal concentrations,MBC)和最小抑菌浓度(minimum inhibitory concentrations,MIC).棒状纳米金、三角形纳米金、球形纳米金对大肠杆菌的MIC分别为0.65μg/mL、3.71μg/mL、21.21μg/mL,MBC分别为1.30μg/mL、11.09μg/mL、21.21μg/mL;对金黄色葡萄球菌的MIC分别为0.26μg/mL、0.56μg/mL、2.65μg/mL,MBC分别为0.52μg/mL、1.11μg/mL、2.65μg/mL.结果表明无论是对大肠杆菌还是金黄色葡萄球菌,棒状纳米金的杀菌效果均高于其它两种形态,并且三种不同形态的纳米金对金黄色葡萄球菌的杀菌效果均优于大肠杆菌.     

一个新型双核Schiff base镉配合物的合成、结构表征及体外抗临床分离多重耐药菌的作用研究

以N,N'-二(邻羟亚苄基)-1,2邻苯二胺为配体合成一个新型双核Schiff base镉配合物1.通过红外、单晶衍射对其进行了结构表征.应用Kerby-Bauer纸片扩散法分别测试其对临床分离的不同多药耐药的金黄色葡萄球菌、大肠埃希菌、真菌的抗菌活性.通过微量稀释法测定合成配合物的最低抑菌浓度[minimum inhibitory concentration(MIC)]、最低杀细菌浓度[minimum bactericidal concentration(MBC)].抑菌试验结果表明,配合物1对临床分离金黄色葡萄球菌和大肠埃希菌都有明显的抑菌效果,且对金黄色葡萄球菌的抑菌作用较大肠埃希菌强.配合物1对临床分离金黄色葡萄球菌的MIC值为15.625~62.5μg/m L,MBC值为31.25~125μg/m L;配合物1对对临床分离大肠埃希菌的MIC值为31.25~62.5μg/m L,MBC值为62.5~125μg/m L.     

复方联苯苄唑液实验室抑菌试验研究

目的研究复方联苯苄唑液的抑菌效果及组方的科学合理性,用于临床治疗皮肤癣菌病.方法用11种88株临床常见的标准菌株,采用体外抑菌试验的药基法,同单方联苯苄唑和达克宁霜的MIC体外抑菌试验对比研究.结果复方联苯苄唑液对念珠菌、红色毛癣菌、须癣菌、疣状毛癣菌、紫色毛癣菌、许兰氏黄癣菌、絮状表皮癣菌及犬小孢子菌的MIC均小于单方联苯苄唑及迭克宁.结论复方联苯苄唑液的组方科学合理,各组份有协同抑菌作用,可用于临床治疗皮肤癣菌病.     

壳聚糖碘液抗白色念珠菌活性的研究

采用MTT法等方法研究壳聚糖碘液对白色念珠菌的抑制作用,结果得到壳聚糖碘液的50%抑菌浓度（MIC50）和最小菌浓度（MBC）分别为250 mg/L和600 mg/L。实验结果表明壳聚糖碘液具有良好的杀白色念珠菌效果。     

β-内酰胺类抗生素对聚磷菌最小抑菌浓度的影响

为本研究以聚磷菌作为受试生物,大肠埃希菌和铜绿假单胞菌作为质控菌属,采用微量肉汤稀释法,测定β-内酰胺类抗生素中阿莫西林、头孢哌酮、氨曲南对聚磷菌的最小抑菌浓度(MIC).结果显示,阿莫西林、头孢哌酮对大肠埃希菌的最小抑菌浓度分别为"4~8μg/m L、0.25~0.5μg/m L",氨曲南对铜绿假单胞菌的最小抑菌浓度为"2~4μg/m L",符合CLSI标准;阿莫西林、头孢哌酮、氨曲南对聚磷菌的最小抑菌浓度分别为"8~16μg/m L、0.5~1μg/m L、4~8μg/m L".     

土木香内生细菌的分离鉴定及抑菌活性检测

利用组织分离法从用药植物土木香根、茎和叶中分离得到内生细菌32株.采用纸片法对菌株进行了抑菌活性研究,并运用生理生化与分子生物学方法进行种类鉴定.抑菌试验结果表明,10株内生菌发酵液对大肠杆菌、枯草芽孢杆菌以及禽多杀性巴氏杆菌均有不同程度的抑菌活性.鉴定结果表明,菌株YIR-5,YIR-7,YIR-8,YIR-9为假单胞菌属菌种,菌株YIR-3,YIR-6为沙雷氏菌,菌株YIR-4,YIS-1,YIS-2分别为水生拉恩氏菌、薄壁芽孢杆菌和蜡样芽孢杆菌,而菌株YIL-3归属于芽孢杆菌属.土木香内生细菌组成丰富,莫海威芽孢杆菌（Bacillus mojavensis）YIS-1对大肠杆菌、枯草芽孢杆菌和禽多杀性巴氏杆菌的抑菌活性最强.     

紫草素体外抗菌活性的实验研究

目的:本文主要研究紫草主要成分紫草素体外抗菌活性及其抗菌谱.方法:用琼脂平板法测定紫草素的抗菌谱;以左氧氟沙星为阳性对照药,通过试管二倍稀释法检测紫草素最低抑菌浓度(MIC)和最低杀菌浓度(MBC).结果:紫草素对多种常见菌株包括革兰阳性菌、革兰阴性菌以及真菌显示出抗菌作用,对金黄色葡萄球菌(MIC为6.25μg·mL~(-1),MBC为25.0μg·mL~(-1))、大肠埃希菌菌(MIC为12.5μg·mL~(-1),MBC为25.0μg·mL~(-1))、白色念珠菌(MIC为1.563μg·mL~(-1),MBC为3.125μg·mL~(-1))、蜡状芽孢杆菌(MIC为1.563μg·mL~(-1),MBC为6.25μg·mL~(-1))、沙门氏菌(MIC为25.0μg·mL~(-1),MBC100.0μg·mL~(-1))的生长有显著的抑制作用.抗菌能力与左氧氟沙星相当.结论:紫草素具有良好的抗菌作用,具有成为抗菌药物先导化合物的条件.     

野菊花等复方中药水煎液体外抗大肠杆菌活性研究

用野菊花、薄荷、藁本制备复方中药的水煎液,用药敏纸片法对其进行抑菌圈实验,并用二倍稀释法和营养琼脂扩散法测定复方中药提取液最低抑菌浓度(MIC)和最低杀菌浓度(MBC),最后通过光电比浊计数法测定菌液吸光度随时间变化所反映的生存曲线.结果表明:复方中药水煎液出现明显的抑菌圈;大肠杆菌的MIC为250 g/L,MBC为500 g/L;药液浓度大于125 g/L时,中药水煎液对大肠杆菌有明显的抑菌效果.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

On the Thermodynamic Limit for Responses to Static Electromagnetic Fields

For molecular systems,the quantum-mechanical treatment of their responses to static electromagnetic fields usually employs a scalar-potential treatment of the electric field and a vector-potential treatment of the magnetic field.Although the potential for each field separately is associated with the choice of an(unphysical)origin,the precise choice of the origin for the electrostatic field has little consequences for the results.This is different for the     

An affordable accurate evaluation of the binding conformations predicted by molecular docking studies in bio-system

Franck-Condon factors bridge the gap between theoretical modeling and experimental observations for molecular electronic spectroscopy and electron transfer.Under the displaced harmonic oscillator approximation,multidimensional Franck-Condon factors are decomposed into a product of many one-dimensional(1D)Franck-Condon(FC)factors,and each 1D-FC factor is associated with one Huang-Rhys factor that determines the leading contribution of     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with