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1.
Summary After administration of cortexone to a normal man, we isolated the 5-pregnana 3, 21-diol 20-one glucuronide in human urine. We found 90% of this corticosteroid in the glucuronide fraction; the remaining 10% was in the free fraction.We found neither the cortexone nor its metabolites dior tetrahydrogenated in the ester-sulphate fraction.The tetrahydrocortexone-glucuronide was identified by paper chromatography and by electrophoresis. 相似文献
2.
Summary 5-pregnane 11, 17, 21-triol 3, 20-dione (dihydrocortisol) has been isolated and identified in the urine of patients with feminizing adrenal cortical cancer. This steroid showed the same Rf as synthetic dihydrocortisol in six different chromatographic systems. After acetylation, its Rf was the same as that of 21 monoacetate of dihydrocortisol. After bismuthic or chromic oxydation, it had the same chromatographic Rf as 5-androstane 11-ol 3, 17-dione and 5-androstane 3, 11, 17-trione respectively. After chromic oxydation of its acetate, the Rf was the same as that of 21 monoacetate of cortisone. 相似文献
3.
F. W. Kahnt R. Neher K. Schmid A. Wettstein 《Cellular and molecular life sciences : CMLS》1961,17(1):19-21
Summary The transformation of 5-pregnenolone into 17-hydroxy-5-pregnenolone, and of the latter into DHA, is shown to occur in homogenates and fractions thereof, both of bovine adrenal and testicular tissue. The relative significance of these reactions for the biogenesis of androgens in normal and neoplastic tissue is discussed.
173. Mitteilung über Steroide; 172. Mitteilung:P. Wieland, K. Heusler undA. Wettstein, Helv. chim. Acta43, 2066 (1960). 相似文献
173. Mitteilung über Steroide; 172. Mitteilung:P. Wieland, K. Heusler undA. Wettstein, Helv. chim. Acta43, 2066 (1960). 相似文献
4.
S. Schwarz W. Pohnert A. Stachowiak D. Onken 《Cellular and molecular life sciences : CMLS》1963,19(3):128-129
Summary 5- and 5-androstane-17-ol-3-one-17-acetate have been prepared from 5-androstane-6, 17-diol-3-one-17-acetate by a synthesis involving directedHuang-Minlon-reduction.Separation of 5-androstane-17-ol-3-one from its 5-isomer could readily be achieved by crystallisation of their 3-ethylenketals from acetone. 相似文献
5.
Y. Fujimoto N. Ikekawa M. Ogiso E. Ohnishi 《Cellular and molecular life sciences : CMLS》1986,42(5):567-568
Summary The structures of the metabolites formed upon incubation of 17-estradiol with the ovaries of silkworm,Bombyx mori, have been determined as 17-estradiol 3-(-D-glucopyranoside) (1) and 17-(-D-glucopyranoside) (2) by spectroscopic means. 相似文献
6.
H. Immer M. Lj. Mihailović K. Schaffner D. Arigoni O. Jeger 《Cellular and molecular life sciences : CMLS》1960,16(12):530-532
Summary On treatment of 3-hydroxy-5-steroids with lead tetra-acetate formation of 3, 9-oxides is observed. The yields of this ring closure reaction decrease significantly in the order 11-keto, 9, 11-ene and ring-C saturated compounds. 相似文献
7.
R. Kato 《Cellular and molecular life sciences : CMLS》1959,15(11):424-425
Riassunto Recentemente è stata formulata l'ipotesi che la 5-idrossitriptamina e la noradrenalina agiscano come mediatori a livello del S.N.C. I risultati ottenuti dall'A. dimostrano che la diossifenilalanina può antagonizzare il potenziamento della narcosi barbiturica indotto dal 5-idrossitriptafano.
Research fellow from Keio University, Tokyo (Japan). 相似文献
Research fellow from Keio University, Tokyo (Japan). 相似文献
8.
研究了熔体快淬工艺及添加元素Ti对Sm—Fe合金相的形成及结构的影响,成功制备了Sm3(Fe,Ti)29Nx/α-Fe双相纳米耦合永磁材料.研究发现,快淬薄带由Sm3(Fe,Ti)29和α-Fe两相组成,晶化前在纳米晶周围存在部分非晶相,晶化后的晶粒间晶界平直光滑、且晶粒间结合紧密没有界面相,为晶粒间直接接触耦合.对甩带后的样品采用750℃保温10min的晶化退火得到的颗粒比较细小且均匀.氮化磁粉磁滞回线的第二象限没有出现明显的台阶,表现为单相永磁材料的特点,说明硬磁相Sm3(Fe,Ti)29M与软磁相α-Fe晶粒之间的交换耦合作用已形成. 相似文献
9.
T. T. Yen J. A. Allan D. V. Pearson J. M. Acton 《Cellular and molecular life sciences : CMLS》1978,34(12):1542-1543
Summary Treating VY/WfL-A
vy
/a mice with 5-androstan-17-one, a mammalian glucose-6-phosphate dehydrogenase inhibitor, prevented the mice from becoming obese. The weight difference between treated and controlA
vy
/a mice was mainly due to a decreased accumulation of triacylglycerol. The compound did not suppress appetite, had no detectable toxicity and did not affect the lipogenesis rates in the liver and carcass. The weight-controlling effect of 5-androstan-17-one inA
vy
/a mice was reversible upon withdrawal of treatment.The authors wish to thank Mr W.R. Gibson and Drs C.G. Culbertson and P.N. Harris for performing the pathological examinations. 相似文献
10.
《世界科技研究与发展》2016,(4)
若n阶平面图G的任一子图都不与H_1同构,且G的任一子图都不与H_2同构,则G称为(H_1,H_2;n)-平面图;平面Ramsey数指不存在(H_1,H_2;n)-平面图的最小n。本文利用对称性及反证等方法,得到了所有的极小(C_4,K_5;11)-平面图,有助于证明平面Ramsey数。 相似文献
11.
H. Smith G. A. Hughes G. H. Douglas D. Hartley B. J. McLoughlin J. B. Siddall G. R. Wendt G. C. Buzby Jr. D. R. Herbst K. W. Ledig J. R. McMenamin T. W. Pattison J. Suida J. Tokolics R. A. Edgren A. B. A. Jansen B. Gadsby D. H. R. Watson P. C. Phillips 《Cellular and molecular life sciences : CMLS》1963,19(8):394-396
Zusammenfassung Von mehreren (±) 3-Oxy- und (±) 3-Methoxy-13-alkylgona-1,3,5(10)trien-17-onen und verwandten Verbindungen, einschliesslich von Vertretern der (±) 13-Alkylgon-4-en-3-on-Reihe, werden Totalsynthese und biologische Wirksamkeit beschrieben. 相似文献
12.
Zusammenfassung Nebennierenschnitte von Ratten, Meerschweinchen und Menschen synthetisierten 17-Hydroxyprogesteron, 11-Deoxycortisol und Cortisol aus 17-Hydroxypregnenolon. Diese Verbindung, als Ausgangsprodukt für die Cortisolsynthese, ist ebenso wirksam wie pregnenolon. Die Umwandlung von 17-Hydroxypregnenolon in Dehydroepiandrosteron verläuft weniger vollkommen als zu 17-Hydroxycorticoiden. 相似文献
13.
C. Detrain J. M. Pasteels J. C. Braekman D. Daloze 《Cellular and molecular life sciences : CMLS》1987,43(3):345-346
Summary In the European dimorphic ant,Pheidole pallidula, the Dufour's gland of the major workers is hypertrophied and secretes nearly pure (Z, E)--farnesene. This compound is also present in the Dufour's gland of the minor workers but constitutes only around 10% of the volatiles. Chemical polymorphism inP. pallidula is different from that already reported for species ofPheidole from the New World.Aspirante au Fonds National de la Recherche Scientifique.Maître de recherches du Fonds National de la Recherche Scientifique. 相似文献
14.
S. F. Wang J. C. Braekman D. Daloze J. Pasteels P. Soetens N. V. Handjieva P. Kalushkov 《Cellular and molecular life sciences : CMLS》1996,52(6):628-630
The isolation of N-quinaldyl-L-arginine·HCl (1) from the CoccinellidaeSubcoccinella-24-punctata is reported. The structure, first established on the basis of the analysis of the spectral properties of1, has been confirmed by synthesis. The alkaloid is of endogenous origin and markedly deterrent to ants. 相似文献
15.
16.
E. Möller H. Horstmann K. Meng D. Loew 《Cellular and molecular life sciences : CMLS》1977,33(3):382-383
Summary Chemistry, salidiuretic activity and mechanism of action of 3-amino-1-(3,4-dichloro--methyl-benzyl)-2-pyrazolin-5-one (Bay g 2821), a new diuretic, are described. Owing to the initial rapid onset of activity, the reserve in capacity and the additional long duration of activity, this substance represents a potent diuretic and antihypertensive agent. 相似文献
17.
Summary The sterol fraction from leaves of the potato plant,Solanum tuberosum, was found to contain a minor constituent, the structure of which has been established as 4-methyl-5-stigmasta-7,24(28)-diene-3-ol (I). This sterol is most probably identical with 1-sitosterol and has the same constitution as citrostadienol, differing only in the configuration of the
24 (28)-double bond.
Sterine und Triterpenoide. III. Mitteilung. — II. Mitteilung s. 3. 相似文献
Sterine und Triterpenoide. III. Mitteilung. — II. Mitteilung s. 3. 相似文献
18.
Sánchez-Margalet V González-Yanes C Santos-Alvarez J Najib S 《Cellular and molecular life sciences : CMLS》1999,55(1):142-147
Insulin action is initiated by binding to its cognate receptor, which then triggers multiple cellular responses by activating
different signaling pathways. There is evidence that insulin receptor signaling may involve G protein activation in different
target cells. We have studied the activation of G proteins in rat hepatoma (HTC) cells. We found that insulin stimulated binding
of guanosine 5′-O-(3-thiotriphosphate) (GTP-γ-35S) to plasma membrane proteins of HTC cells, in a dose-dependent manner. This effect was completely blocked by pertussis toxin
treatment of the membranes, suggesting the involvement of G proteins of the Gα
i/Gα
o family. The expression of these Gα proteins was checked by Western blotting. Next, we used blocking antibodies to sort out the specific Gα protein activated by insulin stimulation. Anti-Gα
il,2 antibodies completely prevented insulin-stimulated GTP binding, whereas anti-Gα
o,i3 did not modify this effect of insulin on GTP binding. Moreover, we found physical association of the insulin receptor with
Gα
i1,2 by copurification studies. These results further support the involvement of a pertussis toxin-sensitive G protein in insulin
receptor signaling and provides some evidence of specific association and activation of Gα
i1,2 protein by insulin. These findings suggest that Gα
i1,2 proteins might be involved in insulin action.
Received 23 September 1998; received after revision 23 November 1998; accepted 25 November 1998 相似文献
19.
Riassunto Esperienze condotte in ratti e topi parabionti hanno permesso di stabilire che il 3-ciclopentil etere del 17-etinilestradiolo, estrogeno dotato di elevatissima attività uterotrofica per via orale, è parimenti fornito di forte potere inibente sulla secrezione gonadotropa ipofisaria. Pure a dosi minime esso rivela chiare proprietà anticoncezionali nei ratti femmine. Sia come inibitore ipofisario che come inibitore della fertilità, tale composto si dimostra notevolmente più attivo del 3-metil etere del 17-etinilestradiolo. 相似文献
20.
Summary In synthesizing 6-(4-pyridyl)-3-mercapto-1,2,4-tria-zin-5-one from the oxime of 4-pyridyl-glyoxylic acid, isonicotinaldehyde-thiosemicarbazone is obtained through decarboxilation as a by-product, which is mainly responsible for the tuberculostatic properties. 相似文献