Sesquiterpenoids minor constituents ofPinus parviflora. On the relationship between (−)-δ-cadinol, (+)-δ-cadinol,sesquigoyol, torreyol,and brown alga cadinol

Zusammenfassung 1-Dokosanol, Sesquigoyol,-Sitosterin und 3,5-Dimethoxystilben wurden ausP. formosana isoliert. Es konnte gezeigt werden, dass Sesquigoyol der optische Antipode von (–)--Cadinol ist.

---

---

Sesquiterpenoids II. For the previous paper in this series, seeW. G. Dauben, B. Weinstein, P. Lim, andA. B. Anderson, Tetrahedron15, 217 (1961).

---

On leave of absence from the Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China.

---

The National Council of Science, Republic of China, is thanked for the award of a fellowship for advanced study to one of us (K.-T.W.).     

In Memoriam Pau Hoffmann 1. Juli 1884-9. März 1962

Ohne Zusammenfassung

---

In Memoriam Pau Hoffmann 1. Juli 1884-9. März 1962

     

The use of benzylpenicillinacylase fromEscherichia coli in the resolution of some racemicβ-,γ-,δ- andɛ-amino-acids

Summary The enzymatic hydrolysis of N-phenylacetyl derivatives of racemic amino-acids having the chiral centre removed from the usual -position is examined. The reaction is found to have different degrees of stereoselectivity. In the case of -amino-acids and of -aminovaleric acid, both enantiomers can be obtained in good yields and high optical purity. S-directed stereochemical preference was found for all the substrates examined.     

Über die Alkaloide vonRauwolfia ligustrina R. & S. Raugustin,ein neues reserpinähnliches Alkaloid

Summary Twenty-one alkaloids have been identified from the root ofRauwolfia ligustrina R. & S. The more important ones are reserpine, pseudoreserpine and raugustine, a new base which is isomer to pseudoreserpine. The structure of the latter compound is discussed.

---

---

Mitteilung über Rauwolfia-Alkaloide

---

Mitteilung sieheC. F. Huebner undE. Schlittler, J. Amer. chem. Soc.79, 250 (1957).     

TRH analogue with C-terminal thioamide group. Synthesis,receptor binding,TSH-releasing activity and α-MSH-releasing activity

Summary A new TRH analogue containing a C-terminal thioamide group was synthesized. This peptide was shown to have receptor-binding affinity, and TSH- as well as -MSH-releasing activities very similar to native TRH.Acknowledgments. This work was supported by the Swedish Natural Science Research Council (K-KU 3020-112) and the Polish Academy of Sciences (Research Grant No. MR I 12.1.6.1).     

Actions de la néostigmine,du D.F.P. et du 3318 CT sur la sensibilité du rectus de grenouille aux esters acétique,propionique et butyrique de la choline

Summary The potentiating effects of Neostigmine, D.F.P. and 3318 CT (a selective true cholinesterase inhibitor) on acetylcholine (ACh), propionylcholine (PrCh), butyrylcholine (BuCh) and amyltrimethylammonium (AmT), have been studied using the frog's rectus abdominis. Neostigmine increases the actions of the three esters much more than that of AmT. Low concentrations of D.F.P. potentiate maximally BuCh but have practically no effect on ACh, PrCh, and AmT. 3318 CT potentiates AcCh and PrCh but inhibits BuCh and AmT.These results indicate the specificity of the hydrolysis of pharmacologically active doses of BuCh, on the one hand, of AcCh and PrCh, on the other hand, by different enzymes or the frog's rectus.Results obtained with high concentrations of D.F.P. and with association of the different anticholinesterases indicate that a maximal or nearly maximal potentiation of one of these esters is already obtained with the specific inhibitor concerned; the supplementary inhibition of the non-specific enzymes thus appears to have no or only a poor effect.