Die Wirkung von Kalzium und Serum auf die Wanderung von zitratgeschädigten menschlichen Leukozyten

Summary In the inhibition of the migration of human leucocytes by tribasic sodium citrate conditions are similar to those in the inhibition of phagocytosis directed againstE. coli. At least two elements important for the migration are inactivated by citrate: (1) the free calcium ions, (2) serum factors whose nature is yet unclear. The inhibition of the migration of leucocytes by sodium citrate is reversible. Leucocytes inhibited by citrate acquire full capacity to migrate again after addition of calcium ions and serum factor.     

Die Wirkung der Nukleinsäuren auf die Bakterienphagozytose der Leukozyten

Summary Sodium ribonucleinate and sodium desoxyribonucleinate increasesin vitro the phagocytosis of surviving rat's leucocytes. The average figure for the effect is greater than the limits of error, even in dilutions of 1:100,000. In dilutions of 1:10,000, the action is more striking, the results being 33% and 29% respectively above the control value.     

Wirkung von Polysacchariden bakterieller Herkunft auf die experimentelle Lipämie

Summary Polysaccharide fractions derived from a gram-negative proteus organism show strong anti-lipaemic activity of the order of 1000 times that of heparin. Analogous preparations from gram-positive organisms and mycobacteria show no such activity and some polysaccharide fractions from plant and animal tissues proved to have slight activity. None of these polysaccharides influenced the clotting of plasmain vitro.     

Über die Wirkung von Elastase auf die Blutgerinnung

Summary Purified elastase prepared by adsorption on synthetic zeolite in proper concentrations causes the coagulation of blood. Elastase was found to have no direct coagulative action on purified fibrinogen. Its coagulating action is due to the fact that it reacts with prothrombin to form thrombin. The reaction between prothrombin and elastase is independent of the presence of either platelets, thromboplastin or Ca-ions.     

Die Wirkung einer Leberschädigung durch Thioacetamid auf die mikrosomale Aromatisierung von Testosteron bei der Ratte

Summary Rat liver microsomes, NADPH-regenerating system, and 1, 2-³H-testosterone have been incubated in vitro. The loss of tritium from the steroid, associated with aromatization of testosterone, was linear with time for 20 min and required NADPH. Pre-treatment of the rats with thioacetamide raised the liberation of tritium from 1, 2-³H-testosterone. The results suggest that liver damage by thioacetamide in rats may give rise to increased aromatization of testosterone.     

Die Wirkung von D-Lysergsäure-diäthylamid (LSD 25) und 5-Oxytryptamin auf die Chromatophoren vonPoecilia reticulatus

Summary D-lysergic acid diethylamide (LSD 25) has a characteristic effect on the chromatophores of the female fish guppy (Poecilia reticulatus). This effect can be prevented by prophylactic administration of 5-hydroxytryptamine (serotonin, enteramine).     

Die Wirkung von Kalium und Calcium auf das Treppenphänomen am Froschherzen

Ohne ZusammenfassungDie Arbeit wurde mit Unterstützung der Roche-Stiftung durchgeführt.     

Stereospezifität der Wirkung von Emetin

Summary (-)-Emetine, as prepared by total synthesis, has the same antiamebic activity and toxicity as the natural alkaloid. On the contrary its antipode and rac. isoemetine are not active and practically non-toxic. A relationship between configuration and antiamebic activity has thus been demonstrated for various representatives of the emetine series.     

Die Wirkung von synthetischen Antihistaminkörpern auf die Senfölchemosis am Kaninchenauge

Summary Intravenous or subcutaneous administration of pyribenzamine and other antihistaminics is able to decrease, and to delay the appearance of chemosis produced by mustard oils in the eye of the rabbit. Simultaneously occurring vascular reactions, on the other hand, are but slightly affected by antihistaminics. Intravenous or subcutaneous administration of rutin has no clear-cut effect on chemosis; it is however able to inhibit the vascular reaction.     

Die Wirkung der Ultraviolettbehandlung auf die Überlebensverhältnisse röntgenbestrahlter Mäuse

Summary 300 r whole body X-ray irradiation of mice did not decrease the circulating platelet count, if this dose was preceeded by 24 h of ultraviolet-irradiation. More animals survived the X-ray (500, 550, 600 r) injury, if the irradiation occurred after ultraviolet treatment given 24 and 48 h before. The number of days survived is also increased. The ultraviolet light seems to have some protective effect against injury caused by X-ray.     

Über die Wirkung von Phenylbutazon auf den Tricarbonsäurezyklus und andere Fermentsysteme

Summary Cholinesterase, hyaluronidase, chondroïtinase and -glucuronidase are not inhibited by phenylbutazone in concentrations up to 10^–3 M.Phenylbutazone accelerates the oxidation of the acids of the Krebs cycle in therapeutic concentrations up to 10 mg%; in higher concentrations it acts as an inhibitor. The inhibition of the -keto acid oxidation begins at lower concentrations of phenylbutazone then for the other intermediates.     

Über die Abhängigkeit der photodynamischen Wirkung von der Intensität der UV.-Bestrahlung

Summary (1) The relation between photodynamic effect and intensity of ultra-violet radiation was investigated by means of the lethal-curve of yeast cells treated with benzpyrene as photosensibilizer.(2) If the dosis of radiation ist kept constant, the resulting photodynamic effect decreases rapidly with diminishing intensity.

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Teilergebnisse der Dissertation.     

Die antibakterielle Wirkung der Usninsäure auf Mykobakterien und andere Mikroorganismen

Summary Usnic acid has already been found in optically active forms in very different quantities in a large number of species of lichens. We have been able to demonstrate the presence of the racemic form of usnic acid as a naturally occuring product in Iceland moss (Cetraria islandica Ach.). The bacteriological examination of the three forms of usnic acid led to the result that, besides an effect uponStaphylococcus aureus, they exert also a very remarkable action againstMycobacteria. The action ofl-usnic acid on different strains ofMycobacteria and other microorganisms is shown in table II. According to the results so far obtained by us, other acids of lichens behave in a similar manner.     

Über die Wirkung von Cobalt-II-nitrat auf Kern und Cytoplasma vonAcetabularia mediterranea

Summary The effect of Cobalt-II-nitrate was tested on the marine green algaAcetabularia. Application of Co immediately stopped regeneration as well as synthesis of cytoplasmic proteins. Later on a decrease of the protein contents was observed. Without affecting the size of the nucleus, Co caused a reduction of the nucleolar size and shape within 4 days. By histochemical methods, Co was found to be stored in the nucleus and nucleolus. However, it is not clear whether the Co was already boundin vivo. Size and distribution of the polyphosphate bodies were not changed within 6 days. No storage of Coin vivo could be observed within the polyphosphates.

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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.     

Elektromyographische Untersuchungen der Wirkung von LSD 25 auf die neuromuskuläre Reizübertragung beim Kaninchen

Riassunto In un lotto di conigli si è indagata, con tests elettromiografici, l'eventuale azione della LSD 25 a livello della giunzione neuromuscolare.Dalle esperienze effettuate è emerso che la sostanza (alla dose di mg 0,05-0,1-0,15 endovena, in animali di kg 2 circa) non possiede nè un'azione curarosimile, nè un'azione anticurarica.Si è potuto rilevare inoltre, con opportune ricerche che la LSD25 non interferisce, in alcun modo, sulla modesta azione anticurarica esercitata dalla serotonina e documentata in altra sede.     

Unterschiedliche Wirksamkeit der 180-keV-und 31-MeV-Strahlen auf die Letalität von C 57-Mäusen

Summary Mice were subjected to irradiation of the whole body with a homogeneous dose of 31 MeV and 180 keV roentgen rays. A quantitative evaluation of effectiveness was obtained, using the survival time of mice (between irradiation and death). The 180 keV rays were more effective than the 31 MeV rays.     

über die Wirkung des Kohlenoxyds auf Atmung und Ionenaufnahme von Weizenwurzeln

Summary The effect of carbon monoxide upon oxygen consumption and ion absorption in wheat roots has been studied. In the dark, inhibition of respiration by CO (in sufficiently high concentrations) is nearly as great as the maximum inhibition in cyanide. Similarly, the chloride absorption is strongly inhibited. Inhibition of respiration and ion absorption by CO is light-reversible.     

Über die Wirkung von Pyribenzamin und anderen Antihistaminika auf die durch Histaminverabreichung erzeugten Magenulzera

Summary Ulcers of the stomac of guinea-pigs, produced by subcutaneous application of histamine, are reduced to a significant degree in number by peroral application of antihistaminics. The effect is corresponding to the given dosage. Pyribenzamin proved to be the most effective.     

Die Infektiosität des Ribonukleinsäureanteils von Maul- und Klauenseuche-Virus

Summary Using the phenol method described byGierer andSchramm, preparations of infective ribonucleic acid were prepared from tongue tissues of cattle infected with the virus of foot-and-mouth disease.