视觉假体微电极阵列的发展与研究现状

针对用于视觉修复的微电极,根据其植入部位(视网膜、视神经、视皮层以及脉络膜上腔和视盘等),分别介绍了国内外各主要研究小组的最新进展及其特点,讨论了设计和制作微电极阵列的关键问题和面临的挑战,对视觉假体微电极阵列用于临床实验具有一定的推动作用.     

激光诱导脉络膜新生血管模型的光学相干断层扫描检查

目的 探讨鉴定脉络膜新生血管(choroidal neovascularization CNV)模型的一种客观可靠的方法.方法 在间接检眼镜下用氩激光光凝有色家兔视网膜,分别于光凝后7、14、21、28天时行视网膜光学相干断层扫描(optical coherence tomography,OCT)和荧光血管造影(FFA),并做组织学检查.结果 光凝后7、14天时,OCT检查见光凝斑视网膜变薄,脉络膜反射被遮蔽,FFA未见荧光渗漏,光镜检查见视网膜神经层变薄.光凝21天后,OCT检查见光凝斑视网膜色素上皮(RPE)层和脉络膜毛细血管层反射光带增厚,光凝后21和28天时,FFA检查分别有55%和35%的光斑有点状荧光渗漏,光镜检查有脉络膜新生血管形成.结论 OCT检查与FFA及组织学检查结果相符合,OCT及FFA检查可作为鉴定是否有CNV形成的客观可靠的方法.     

坐标并行注意力下密集空洞卷积的脉络膜分割

脉络膜的变化与很多眼科疾病密切相关。医生在诊断过程中常需要手动分割光学断层扫描图像(Optical Coherence Tomography, OCT)中的脉络膜，再定量分析脉络膜健康状况，但人工分割费时费力。脉络膜自动分割难点在于OCT图像中脉络膜下边界模糊，很难捕捉上下文信息，并且脉络膜结构跟视网膜结构比较类似，容易混淆。为了解决该难点，本文提出了融合坐标并行注意力模块和密集空洞卷积模块的残差编解码模型；设计了一种桥结构，包含了注意力机制和空洞卷积，在增加模型感受野的同时抑制浅层噪声；同时为了使模型关注脉络膜结构信息，引入了一种包含结构相似性的混合损失函数来训练模型。实验结果表明，该模型能有效提升对脉络膜的分割精度，在OCT脉络膜数据集上，Dice系数和Jaccard相似度达到了97.63%和95.28%。     

眼挫伤的眼底荧光血管造影临床分析

目的：观察眼挫伤后眼络膜、视网膜、视盘上眼底荧光血管造影检查（fundusfluorescein angiography FFA）中的特征和临床意义。方法：对38例眼挫伤患者进行眼底务管造影检查。结果：16眼视盘缺血性改变（g42．1％），视网膜震荡伤23眼（占60．5％），脉络膜破裂10眼（占26．30％），1例视神经撕脱伤。结论：FFA可显示眼挫伤后视盘、视网膜、脉络膜的循环改变，对眼损伤诊断、治疗提供依据。     

中心性浆液性脉络膜视网膜病

通过收集国内外资料，探讨《中心性浆液性脉络膜视网膜病》的病因，发病机理，检查方法及治疗措施等。     

初级视皮层并不唯一

<正>在标准的视觉处理模型中,视网膜接收到的所有视觉信息都会先经过初级视皮层V1,提取出事物的简单特征,再被分发送往更高级的视皮层,提取出更加复杂的特征。而一项于2019年1月4日发表在Science上的研究发现,一个能感知移动物体的高级视皮层POR却偏偏不     

脉络膜新生血管研究进展

脉络膜新生血管(choroidal neovascularization,CNV)是来自脉络膜血管的病理性新生血管侵入视网膜下腔形成.CNV可发生于许多眼底疾病,可引起视网膜出血和渗出,继而可形成瘢痕,造成黄斑部损伤,严重影响中心视力.其发生机制尚未完全清楚,任何原因引起血管生成因子相对或绝对增多就会导致新生血管生成.本文就近几年来国内外在CNV的临床分类和形成机制研究的进展作一综述.     

大鼠视皮层17区的细胞构筑和神经联系

综述了大鼠视皮层１７区的神经元类型，各皮质层的形态学特征以及该区在皮层内和皮层下水平的神经联系。     

高度近视黄斑裂孔性视网膜脱离25例临床观察

目的：探讨巩膜冷冻、环扎及外放液玻璃体腔注气手术治疗高度近视黄斑裂孔性视网膜脱离的疗效及适应范围．方法：回顾性分析1997-10～2002-10，在内蒙古林业总医院行巩膜冷冻、环扎及外放液玻璃体注气治疗的高度近视黄斑裂孔性视网膜脱离患者25例(25眼)的临床资料．结果：术后随访6～12个月，25只眼视网膜完全复位．术后视力≥0．05者21只眼，最佳视力为0．5．结论：适度的巩膜冷冻，可以减少视网膜和脉络膜血管的损伤及术后并发症的发生，巩膜环扎缩小玻璃体腔减轻增殖性视网膜玻璃体病变的牵引，玻璃体腔注气促使视网膜复位，外放液是治疗黄斑裂孔性视网膜脱离的有效方法之一．     

黄斑裂孔性视网膜脱离手术疗效分析

目的：探讨巩膜冷冻、环扎及外放液玻璃体腔注气手术，治疗高度近视黄斑裂孔性视网膜脱离的疗效及适应范围．方法：回顾性分析1996年10月至2002年10月。在我院行巩膜冷冻、环扎及外放液玻璃体注气术治疗的高度近视黄斑裂孔性视网膜脱离患者24例（24）眼的临床资料．结果：术后随访6～12个月，24只眼视网膜完全复位．术后视力≥0.05者21只眼，最佳视力为0．5．结论：适度的巩膜冷冻，可以减少视网膜和脉络膜血管的损伤及术后并发症的发生，巩膜环扎缩小玻璃体腔减轻增殖性视网膜玻璃体病变的牵引，玻璃体腔注气使视网膜复位，外放液是治疗黄斑裂孔性视网膜脱离的有效方法之一．     

中心性浆液性脉络膜视网膜病变治疗新进展

中心性浆液性脉络膜视网膜病变（central serous chorioretinopathy,CSC）是一种常见的视网膜病,其病因不明,是一种自限性疾病,但病情迁延不愈,会导致患者视功能的损害.随着人们对本病的认识不断发展,更多眼科医生主张积极地治疗,笔者就CSC的治疗进展进行阐述.     

以视物变形为首诊的视网膜脱离

目的:分析以视物变形为首诊的视网膜脱离患者误诊原因及治疗效果。方法:回顾性分析2009年1月-2009年12月间67例以视物变形首诊的患者。进行详细病史再询问、详细眼底检查、B超或造影后得出最后诊断并进行手术治疗。结果:67例(67眼)以视物变形首诊患者中视网膜脱离8例(8眼,11.9%),中心性浆液性脉络膜视网膜炎29例(29眼,43.3%),黄斑水肿(10眼,14.9%),老年性黄斑变性(20眼,29.9%)。8例视网膜脱离误诊为中心性浆液性脉络膜视网膜炎(n=4,50%),视网膜色素变性(n=2,25%),黄斑水肿(n=2,25%)。8例视网膜脱离均进行了视网膜手术,术后B超复查视网膜平坦,术后矫正视力均好转(100%,P<0.01)。结论:症状不典型的视网膜脱离容易被误诊,系统的眼部检查和详细鉴别诊断可减少误诊。     

Improving the sintering performance of blends containing Canadian specularite concentrate by modifying the binding medium

Canadian specularite concentrate (CSC) possesses high total iron grade and low impurity content. However, due to the poor granulating performance and weak reactivity of CSC at high temperature, the proportion of CSC used in sintering blends is restricted. In this research, the effects of fine limonite, slake lime, and bentonite particles on the granulation performance of blends containing a high ratio of CSC were studied through granulation test. Based on the test results, the effects of modification of the binding medium on the sintering performance of blends containing a high ratio of CSC were revealed by the sintering pot test. Both the granulation property and sintering performance of blends with a high proportion of CSC were improved by modifying the binding medium.     

Optimal carrier-smoothed-code algorithm for dual-frequency GPS data

Carrier-smoothed-code (CSC) algorithm is an effective pseudorange multipath mitigation technique, which can alleviate the computational burden and reduce the communication bandwidth needed for the transmission of GPS observations. This paper presents an improved Hatch filter and address the optimal CSC algorithm for dual-frequency GPS data based on the optimal parameter estimation theory. The smoothed observations have the same information content as that of the raw dual-frequency GPS data from which they are derived. Consequently, the optimal CSC algorithm is equivalent to the uncombined algorithm. Theoretical analyses show that the data precision of the optimal CSC algorithm is better than that of Hatch filter and its improved version.     

Optimal carrier-smoothed-code algorithm for dual-frequency GPS data

Carrier-smoothed-code （CSC） algorithm is an effective pseudorange multipath mitigation technique, which can alleviate the compu- tational burden and reduce the communication bandwidth needed for the transmission of GPS observations. This paper presents an improved Hatch filter and addresses the optimal CSC algorithm for dual-frequency GPS data based on the optimal parameter estimation theory. The smoothed observations have the same information content as that of the raw dual-frequency GPS data from which these are derived. Consequently, the optimal CSC algorithm is equivalent to the uncombined algorithm. Theoretical analyses show that the data orecision of the optimal CSC algorithm is better than that of Hatch filter and its imoroved version.     

Comparison of CSC method and the B-net method for deducing smoothness condition

The first author of this paper established an approach to study the multivariate spline over arbitrary partition, and presented the so-called conformality method of smoothing cofactor (the CSC method). Farin introduced the B-net method which is suitable for studying the multivariate spline over simplex partitions. This paper indicates that the smoothness conditions obtained in terms of the B-net method can be derived by the CSC method for the spline spaces over simplex partitions, and the CSC method is more capable in some sense than the B-net method in studying the multivariate spline.     

A novel strategy for cancer treatment: Targeting cancer stem cells

Cancer stem cell/tumor-initiating cell （CSC/TIC） is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recurrence and tumor resistance to radiotherapy and chemotherapy. At present, small molecule inhibitors and fusion proteins are widely used in the CSC-targeting strategy. Gene-virotherapy, which uses oncolytic adenovirus as a vector to mediate the expression of therapeutic gene, shows a significant superiority to other regimens of cancer treatment and has a good efficacy in the treatment of solid tumors. Thus, it is a promising choice to apply gene-virotherapy into the CSC-targeting treatment. Based on the molecular mechanism underlying CSC self-renewal, a series of effective strategies for targeting CSC have been established. This review will summarize the recent research progresses on CSC-targeting treatment.     

企业利益相关者利益与煤炭企业效益实证研究

采用多个能反映不同利益相关者利益的指标,应用Cross-section及时间序列方法和联立方程对煤炭企业效益与其利益相关者之间的关系进行了分析,并对Freeman利益相关者理论进行了论证,研究结果表明企业效益与其利益相关者之间存在着很强的定量关系。     

CSC浆液性能特征及理论分析

本文在室内试验基础上,全面分析研究了CSC浆液主要性能特征及其影响因素.在理论研究中,着重分析了新型材料的粘塑性特征。研究结果表明,CSC浆液具备良好的性能特征,塑性强度增长规律与注浆——堵水过程相适应。     

改进的色彩结构码彩色分割算法在数字化虚拟人研究中的应用

对色彩结构码（CSC）算法做了改进,将图像边界信息结合进CSC算法的连接过程,并以色度、饱和度、亮度（HSV）色彩模型为基础确定色彩差别．通过设定颜色差别和边界梯度的容忍闽值控制分割的深度．实验用中国虚拟人（VCH）和虚拟人计划（VHP）数据集的彩色切片图像进行分割．结果表明,分割结果比原算法更准确,而且克服了原算法因分割结果对容忍阈值非常敏感而难于取得合适的容忍闽值的缺点．