6-azauridine in brain tissue during chick embryonal development

Résumé 10 mg d'azauridine-6 ont été injectés dans les ufs au 4è et au 8è jour d'incubation. Dans nos précédentes expériences, cette dose a provoqué des malformations dans les embryons du poulet. La concentration de l'azauridine-6 a été déterminée dans le cerveau des embryons et on a trouve qu'elle varie de 0,48–1,16 mg pour 1 g du poids sec du cerveau, du 14è au 20è jour d'incubation.     

Multiplicity of monoamine oxidase in chick brain

Summary The substrate- and inhibitor-related characteristics of monoamine oxidase (MAO) were studied on chick brain mitochondria. It was found that neither 5-hydroxytryptamine nor -phenylethylamine is the specific substrate for type A and type B MAO in chick brain.     

Differentiation of chick embryo brain cells in culture

Résumé Des cellules, encore à un stade indifférencié, dissociées d'hémisphères cérébraux d'embryon de Poulet ont formé, en culture, des fibres nerveuses. La plupart des cellules se différencient en neuroblastes unipolaire et bipolaire; certaines évoluent vers le type multipolaire sans contact direct avec des cellules gliales.

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Chargée de Recherche au CNRS.     

Multiplicity of monoamine oxidase in chick brain.

The substrate- and inhibitor-related characteristics of monoamine oxidase (MAO) were studied on chick brain mitochondria. It was found that neither 5-hydroxytryptamine nor beta-phenylethylamine is the specific substrate for type A and type B MAO in chick brain.     

Transplantation of brain tissue in the brain of adult rats

Summary Brain tissues obtained from rat embryos were transplanted in the forebrain and/or cerebellum of the adult rats. The transplants survived, grew and achieved normal cellular and cytoarchitectural differentiation. They had become anatomically integrated with the host brain. The animals did not show any obviously detectable abnormal behavior or pathology of the brain. The transplants survived as long as the animals did suggesting that they had become a part and parcel of the host brain.Supported by research grants NS-08817 and CA-14650 from N.I.H.     

Alternative pathways of glucose metabolism in developing chick brain

Riassunto È stato studiato il metabolismo di glucosio marcato in C-1 e C-6, nel cervello di pollo in varie fasi di sviluppo. I risultati ottenuti indicano che, mentre nel cervello adulto la massima parte del glucosio viene metabolizzata attraverso il ciclo di Embden-Meyeroff, nel cervello embrionale in fase di sviluppo anche la via di Warburg-Dickens è attivamente operante.

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Work supported by NIH Grant B-3777.     

On the phosphorylation of thiamine in the living animal

Riassunto Gli autori hanno preparato ATP³² dai muscoli di coniglio trattato preventivamente con fosfato di sodio radioattivo. Iniettando per via endovenosa l'ATP³² e tiamina a ratti albini è stato possibile mettere in evidenza, impiegando la tecnica cromatografica su carta, la formazione nel fegato di questi animali di DP³²T e TP³²T. Questi risultati dimostrano che nell'animale vivente ha luogo una diretta trasposizione di gruppi fosforici dall'ATP alla tiamina.     

Changes in the G6PDH/6PGDH ratio in the chick brain during development

Summary The profile of the G6PDH/6PGDH ratio at various stages of development was drawn on the basis of the specific activities of glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconic dehydrogenase (6PGDH) found in the embryonic brain of the chick. The ratio value lower than 1, found in the adult chick brain, is a special biochemical feature which emerges at a certain time-point of development, occurring around the middle of the prehatching age.Acknowledgment. This work was supported by grants from M.P.I. and C.N.R.     

On the regulative capacity of the chick embryo limb bud

Zusammenfassung Wenn bei Ablation von 90% des Materials der Flügelanlage von Hühnerembryonen der Stadien 18–20 eine dünne Marginalschicht des Mesenchyms und des deckenden Ektodermsin situ bleibt, erhält man in einem bedeutsamen Prozentsatz der Fälle eine vollständige Regulierung.     

On the presence of glycogen in the rhombencephalon of chick embryos during development

Riassunto Viene condotto uno studio sulla distribuzione del glicogeno nel romboencefalo dell'embrione di pollo durante lo sviluppo. I risultati delle indagini condotte hanno messo in evidenza una caratteristica localizzazione del glicogeno nell'abbozzo del ponte e del bulbo più evidente in embrioni dal 7° al 13° giorno di incubazione. Tale reperto viene discusso nel suo significato.