共查询到20条相似文献,搜索用时 15 毫秒
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A. Gibelli C. Montanari D. Bellani V. Mandelli G. Sacchetti 《Cellular and molecular life sciences : CMLS》1973,29(2):186-187
Riassunto L'effeto inibente di farmaci -bloccanti sull'aggregazione di piastrine umane indotta in vitro mediante ADP è risultato proporzionale alle dosi dei farmaci impiegati. La seguente scala gerarchica di potenza è disposta in ordine decrescente di attività: pindolol, K 4423, propranolol, INPEA. 相似文献
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P. P. Gazzaniga G. Di Macco R. La Mancusa A. Oddi G. Pappalardo F. M. Pulcinelli D. Reggio 《Cellular and molecular life sciences : CMLS》1988,44(10):892-894
Summary Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid, but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations. Desensitization phenomena may be induced either by repeated addition of S-14 or long lasting contact between S-14 and platelets. 相似文献
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P P Gazzaniga G Di Macco R La Mancusa A Oddi G Pappalardo F M Pulcinelli D Reggio 《Experientia》1988,44(10):892-894
Very low concentrations of somatostatin (S-14) strongly potentiate the in vitro aggregation induced by collagen, ristocetin and arachidonic acid, but not that induced by ADP or epinephrine, in both human platelet rich plasmas and gel-filtered platelet preparations. Desensitization phenomena may be induced either by repeated addition of S-14 or long lasting contact between S-14 and platelets. 相似文献
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R. E. A. Gadd S. Clayman D. Hébert 《Cellular and molecular life sciences : CMLS》1971,27(11):1339-1340
Résumé L'agrégation des plaquettes, induite par l'ADP exogène, fut observée par turbidimétrie en mesurant les variations de la densité optique. Le méralluride, le méersalyl et le PCMB préincubés avec les plaquettes de rat et de cobaye préviennent l'agrégation, tandis que l'acide éthacrynique n'a aucun effet. Par contre, le chlorire méthylique de mercure la provoque en l'absence d'ADP. 相似文献
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The effect of the ADP infusion on the basal platelet count was studied in controls and in rats submitted to the exclusion of the following circulatory districts: splenic, renal, cerebral and of a hind-limb. After these exclusions the ADP-induced thrombocytopenia was less marked than the controls. 相似文献
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Summary It is shown that the ability of blood platelets to aggregate in partially and completely sympathectomized rats is significantly lower than in intact animals. The blood clotting system of sympathectomized rats is hyperactive. The sympathectomy-provoked changes may be due to the increased content of adrenaline in the blood. 相似文献
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Defective ristocetin and bovine factor VIII-induced platelet aggregation in normal rats 总被引:1,自引:0,他引:1
G. de Gaetano Maria B. Donati Ine Reyers-Degli Innocenti Maria C. Roncaglioni 《Cellular and molecular life sciences : CMLS》1975,31(4):500-502
Riassunto Le piastrine di 3 diversi ceppi di ratti, contrariamente alle piastrine umane e di cavia, non sono aggregate (sia in vitro che in vivo) nè dalla ristocetine nè dal fattore von Willebrand bovino, porcino o umano, quest'ultimo reso aggregante previo trattamento enzimatico. Tale insensibilità, di cui si è potuta escludere l'origine plasmatica, potrebbe derivare dall'assenza, sulle piastrine di ratto, di un recettore per il fattore von Willebrand (acido sialico?); potrebbe essere cosi spiegata anche la mancata risposta delle piastrine alla ristocetina. Questi risultati suggeriscono che le piastrine di ratto possono essere un utile modello sperimentale per lo studio della sindrome di Bernard-Soulier nell'uomo.
This work was supported by Contract No. 73-00400-04 of the C.N.R., Roma, Italy. The skilful technical assistance of MissAnnalisa Cavenaghi is appreciated. 相似文献
This work was supported by Contract No. 73-00400-04 of the C.N.R., Roma, Italy. The skilful technical assistance of MissAnnalisa Cavenaghi is appreciated. 相似文献
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S. Niewiarowski B. Lipiński R. Farbiszewski A. Poplawski 《Cellular and molecular life sciences : CMLS》1968,24(4):343-344
Résumé Nous avons constaté que le facteur plaquettaire 4 est libéré au début de l'aggrégation des plaquettes par l'ADP et l'adrénaline. Ce phénomène a pu être mis en évidence en étudiant l'activité antihéparinique et l'activité paracoagulante (coagulation non enzymatique de complexes solubles de monomères de fibrine) du facteur plaquettaire 4. 相似文献
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Résumé Des disperisions aqueuses de progestogènes et estrogènes stimulent l'agrégation des plaquettes de cobaye produites par ADP in vitro. Le diéthylstilbestérol et l'hexestrol qui ne sont pas des stéroïdes, mais possèdent une activité estrogénique, ont un effet inhibitoire sur l'agrégation. 相似文献
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